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Information of the project and the call

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The architecture of bacterial chromosome - the cooperation of topoisomerase I and segregation protein ParB in Streptomyces

2016/22/M/NZ1/00122

Keywords:

Streptomyces topoisomerase chromosome segregation ParB DNA topology

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_10: Microbiology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marcin Szafran 

Number of co-investigators in the project: 6

Call: HARMONIA 8 - announced on 2016-06-15

Amount awarded: 910 650 PLN

Project start date (Y-m-d): 2017-04-07

Project end date (Y-m-d): 2021-04-06

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. C-terminal lysine repeats in Streptomyces topoisomerase I stabilize the enzyme-DNA complex and confer high enzyme processivity.
    Authors:
    Strzałka A, Szafran MJ, Strick T, Jakimowicz D
    Academic press:
    Nucleic Acids Research (rok: 2017, tom: 45, strony: 11908-11924), Wydawca: OXFORD UNIV PRESS
    Status:
    Published
    DOI:
    10.1093/nar/gkx827 - link to the publication
  2. Transcriptional Response of Streptomyces coelicolor to Rapid Chromosome Relaxation or Long-Term Supercoiling Imbalance.
    Authors:
    Szafran MJ, Gongerowska M, Małecki T, Elliot M
    Academic press:
    Frontiers in Microbiology (rok: 2019, tom: 10, strony: 45309), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fmicb.2019.01605 - link to the publication
  3. Amsacrine Derivatives Selectively Inhibit Mycobacterial Topoisomerase I (TopA), Impair M-smegmatis Growth and Disturb Chromosome Replication
    Authors:
    Szafran MJ, Kołodziej M, Skut P, Medapi B, Domagała A, Trojanowski D, Zakrzewska-Czerwińska J, Sriram D, Jakimowicz D
    Academic press:
    Frontiers in Microbiology (rok: 2018, tom: 9, strony: 45304), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fmicb.2018.01592 - link to the publication
  4. A highly processive actinobacterial topoisomerase I - thoughts on Streptomyces' demand for an enzyme with a unique C-terminal domain.
    Authors:
    Szafran MJ, Strzałka A, Jakimowicz D
    Academic press:
    Microbiology (rok: 2020, tom: 166, strony: 120-128), Wydawca: Microbiology Society
    Status:
    Published
    DOI:
    10.1099/mic.0.000841 - link to the publication
  5. Compaction and control—the role of chromosome-organizing proteins in Streptomyces
    Authors:
    Szafran MJ., Elliot M., Jakimowicz D.
    Academic press:
    FEMS Microbiology Reviews (rok: 2020, tom: 44, strony: 725-739), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/femsre/fuaa028 - link to the publication
  6. Spatial rearrangement of Streptomyces venezuelae linear chromosome during sporogenic development
    Authors:
    Szafran MJ., Małecki T., Strzałka A., Pawlikiewicz K., Duława J., Zarek A., Kois-Ostrowska A., Findlay K., Le TBK., Jakimowicz D
    Academic press:
    Nature Communications (rok: 2021, tom: 12, strony: 0), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41467-021-25461-2 - link to the publication

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