Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Involvement of stearoyl-CoA desaturase-dependent signaling in pericardial and pericoronary adipose tissue and coronary artery dysfunction in obesity and atherosclerosis

2016/22/E/NZ4/00650

Keywords:

lipotoxicity adipogenesis cardiomyocytes heart adipokines

Descriptors:

  • NZ4_2: Physiology
  • NZ4_11: Metabolism
  • NZ4_12: Other related subjects

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Paweł Dobrzyń 

Number of co-investigators in the project: 6

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 1 986 400 PLN

Project start date (Y-m-d): 2017-05-18

Project end date (Y-m-d): 2024-05-17

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (14)
  • Articles in post-conference publications (8)
  • Book publications / chapters in book publications (2)
  1. Cardiac-specific β-catenin deletion dysregulates energetic metabolism and mitochondrial function in perinatal cardiomyocytes
    Authors:
    V.V. Balatskyi, V.O. Vaskivskyi, A. Myronova, D. Avramets, K. Abu Nahia, L.L. Macewicz, T.P. Ruban, D. Yu Kucherenko, O.O. Soldatkin, I.V. Lushnikova, G.G. Skibo, C.L. Winata, P. Dobrzyn*, O.O. Piven
    Academic press:
    Mitochondrion (rok: 2021, tom: 60, strony: 59-69), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mito.2021.07.005 - link to the publication
  2. The role of stearoyl-CoA desaturase in the regulation of cardiac metabolism
    Authors:
    S. Tabaczar, M. Wołosiewicz, A. Filip, A. Olichwier, P. Dobrzyń
    Academic press:
    Postepy Biochem (rok: 2018, tom: 64, strony: 183 - 189), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2018_130 - link to the publication
  3. Induction of glutathione synthesis provides cardioprotection regulating NO, AMPK and PPARa signaling in ischemic rat hearts
    Authors:
    Y.V. Goshovska, R.A. Fedichkina, V.V. Balatskyi, O.O. Piven, P. Dobrzyn, V.F. Sagach
    Academic press:
    Life (rok: 2021, tom: 11, strony: 631), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/life11070631 - link to the publication
  4. Mitochondria and reactive oxygen species in aging and age-related diseases
    Authors:
    C. Giorgi, S. Marchi, I.C.M. Simoes, Z. Ren, G. Morciano, M. Perrone, P. Patalas-Krawczyk, S. Borchard, P. Jędrak, K. Pierzynowska, J. Szymański, D.Q. Wang, P. Portincasa, G. Węgrzyn, H. Zischka, P. Dobrzyn, M. Bonora, J. Duszynski, A. Rimessi, A. Karkucinska-Wieckowska, A. Dobrzyn, G. Szabadkai, B. Zavan, P.J. Oliveira, V.A. Sardao, P. Pinton, M.R. Wieckowski
    Academic press:
    Int Rev Cell Mol Biol (rok: 2018, tom: 340, strony: 209 - 344), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/bs.ircmb.2018.05.006 - link to the publication
  5. Role of stearoyl-CoA desaturase 1 in cardiovascular physiology
    Authors:
    V.V. Balatskyi, P. Dobrzyn
    Academic press:
    Int J Mol Sci (rok: 2023, tom: 24, strony: 5531), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24065531 - link to the publication
  6. Alterations of lipid metabolism in the heart in spontaneously hypertensive rats precedes left ventricular hypertrophy and cardiac dysfunction
    Authors:
    T.K. Bednarski, M.K. Duda, P. Dobrzyń
    Academic press:
    Cells (rok: 2022, tom: 11, strony: 3032), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11193032 - link to the publication
  7. Cardiospecific deletion of αE-catenin leads to heart failure and lethality in mice
    Authors:
    V.V. Balatskyi, L.L. Macewicz, A.M. Gan, S.V. Goncharov, P. Pawelec, G.V. Portnichenko, T.Y. Lapikova-Bryginska, V.O. Navrulin, V.E. Dosenko, A. Olichwier, P. Dobrzyn, O.O. Piven
    Academic press:
    Pflugers Arch - Eur J Physiol (rok: 2018, tom: 470, strony: 1485 - 1499), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00424-018-2168-2 - link to the publication
  8. SCD1 regulates the AMPK/SIRT1 pathway and histone acetylation through changes in adenine nucleotide metabolism in skeletal muscle
    Authors:
    A. Dziewulska A, A.M. Dobosz, A. Dobrzyn, A. Smolinska, K. Kolczynska, J.M. Ntambi, P. Dobrzyn
    Academic press:
    J Cell Physiol (rok: 2020, tom: 1865, strony: 1129-1140), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jcp.29026 - link to the publication
  9. Interplay between thyroid hormones and stearoyl-CoA desaturase 1 in the regulation of lipid metabolism in the heart
    Authors:
    A. Olichwier, V.V. Balatskyi, M. Wolosiewicz, J.M. Ntambi, P. Dobrzyn
    Academic press:
    Int J Mol Sci (rok: 2021, tom: 22, strony: 109), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22010109 - link to the publication
  10. Fat and sugar - a dangerous duet. A comparative review on metabolic remodeling in rodent models of nonalcoholic fatty liver disease
    Authors:
    I.C.M. Simoes, J. Janikiewicz, J. Bauer, A. Karkucinska-Wieckowska, P. Kalinowski, A. Dobrzyń, A. Wolski, M. Pronicki, K. Zieniewicz, P. Dobrzyń, M. Krawczyk, H. Zischka, M.R. Wieckowski, Y. Potes
    Academic press:
    Nutrients (rok: 2019, tom: 11, strony: 2871), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu11122871 - link to the publication
  11. Oleic acid increases the transcriptional activity of FoxO1 by promoting its nuclear translocation and β-catenin binding in pancreatic β-cells
    Authors:
    M. Jazurek-Ciesiolka, J. Janikiewicz, P. Dobrzyn, A. Dziewulska, K. Kozinski, A. Dobrzyn
    Academic press:
    Biochim Biophys Acta Mol Basis Dis (rok: 2019, tom: 1865, strony: 2753-2764), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2019.06.018 - link to the publication
  12. Role of perivascular adipose tissue-derived adiponectin in vascular homeostasis
    Authors:
    A. Sowka, P. Dobrzyn
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 1485), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10061485 - link to the publication
  13. Stearoyl-CoA desaturase regulates angiogenesis and energy metabolism in ischemic cardiomyocytes
    Authors:
    A.M. Gan, Z. Tracz-Gaszewska, A. Ellert-Miklaszewska, V.O. Navrulin, J.M. Ntambi, P. Dobrzyń
    Academic press:
    Int J Mol Sci (rok: 2022, tom: 23, strony: 10459), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms231810459 - link to the publication
  14. β-Catenin regulates cardiac energy metabolism in sedentary and trained mice
    Authors:
    V.V. Balatskyi, O.L. Palchevska, L. Bortnichuk, A.M. Gan, A. Myronova, L.L. Macewicz, V.O. Navrulin, L.V. Tumanovska, A. Olichwier, P. Dobrzyn*, O.O. Piven
    Academic press:
    Life (rok: 2020, tom: 10, strony: 357), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/life10120357 - link to the publication
  1. Role of stearoyl-CoA desaturase in cardiovascular system: alternations in cell metabolism and tissue remodeling
    Authors:
    A. Filip, A. Olichwier, M. Wołosiewicz, A.M. Gan, P. Dobrzyn
    Conference:
    60th International Conference on the Bioscience of Lipids (rok: 2019, ), Wydawca: ICBL
    Data:
    konferencja 43633
    Status:
    Published
  2. Stearoyl-CoA desaturase 1 regulates perivascular adipose tissue mitochondrial activity and inflammation in response to obesity
    Authors:
    A. Sówka, P.Dobrzyń
    Conference:
    6th PhD Student Conference (rok: 2022, ), Wydawca: Nencki Institute
    Data:
    konferencja 17-18 październik
    Status:
    Published
  3. Regulation of vascular smooth muscle cell metabolism and vascular tissue remodeling – the role of stearoyl-CoA desaturase
    Authors:
    A. Filip, V. Navrulin, M. Wołosiewicz, A. Olichwier, P. Dobrzyń
    Conference:
    44th FEBS Congress (rok: 2020, ), Wydawca: Wiley
    Data:
    konferencja 44018
    Status:
    Published
  4. Role of stearoyl-CoA desaturase 1 in the regulation of perivascular adipose tissue function
    Authors:
    A. Sówka, P. Dobrzyń
    Conference:
    7th PhD Student Conference (rok: 2023, ), Wydawca: Nencki Institute
    Data:
    konferencja 19-20 październik
    Status:
    Published
  5. Stearoyl-CoA desaturase 1 affects damaged mitochondrial dynamics after doxorubicin treatment
    Authors:
    O. Blesznowska, V. Baltskyi, A. Olichwier, P. Dobrzyn
    Conference:
    28th Congress of the Polish Physiological Society (rok: 2021, ), Wydawca: Polskie Towarzystwo Fizjologiczne
    Data:
    konferencja 44454
    Status:
    Published
  6. Stearoyl-CoA desaturase 1 deficient perivascular adipocytes are metabolically activated and resistant to palmitate induced mitochondrial alterations
    Authors:
    A. Sowka, P. Dobrzyn
    Conference:
    10th Mitochondrion Meeting (rok: 2023, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 20-21 czerwiec
    Status:
    Published
  7. Stearoyl-CoA desaturase 1 deficiency in perivascular adipocytes induces phenotypic switch in vascular smooth muscle cells
    Authors:
    A. Sówka, V. Balatskyi, P. Dobrzyń
    Conference:
    63rd International Conference on the Bioscience of Lipids (rok: 2023, ), Wydawca: ICBL
    Data:
    konferencja 2-5 październik 2023
    Status:
    Published
  8. Stearoyl-CoA desaturase 4 deficiency protects against high fat diet-induced heart dysfunction in mouse
    Authors:
    M. Wolosiewicz, A. Filip, M. Duda, A. Olichwier, V. Navrulin, P. Dobrzyn
    Conference:
    28th Congress of the Polish Physiological Society (rok: 2021, ), Wydawca: Polskie Towarzystwo Fizjologiczne
    Data:
    konferencja 44454
    Status:
    Published
  1. Effect of cellular lipids on heart in pathology and physiology
    Authors:
    V.V. Balatskyi, M. Wolosiewicz, A.M. Dobosz, Z. Tracz-Gaszewska, A. Sowka, M. Kendziorek, E. Krogulec, V.O. Navrulin, P. Dobrzyn
    Book:
    Cellular Lipids in Health and Disease (rok: 2023, tom: 1, strony: 303-337), Wydawca: Academic Press
    Status:
    Published
  2. Sphingolipid mediators of cell signaling and metabolism
    Authors:
    A. Dobrzyn, J. Janikiewicz, Z. Tracz-Gaszewska, A. Filip, A.M. Dobosz, E. Krogulec, P. Dobrzyn
    Book:
    Lipid Signaling and Metabolism (rok: 2020, tom: 1, strony: 386-411), Wydawca: Academic Press
    Status:
    Published

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