Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The role of gelsolin and its complexes with LamR and ILK in adhesion to laminin and migration/invasion of normal and tumor cells

2016/22/E/NZ3/00654

Keywords:

gelsolin laminin non-integrin laminin receptor ILK embriogenesis chicken embryo tumorigenesis melanoma migration invasion

Descriptors:

  • NZ3_1:
  • NZ3_13:
  • NZ3_14:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Antonina Joanna Mazur 

Number of co-investigators in the project: 5

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 2 046 150 PLN

Project start date (Y-m-d): 2017-05-05

Project end date (Y-m-d): 2023-11-04

Project duration:: 78 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  • Book publications / chapters in book publications (1)
  1. Integrin‐linked kinase (Ilk) plays an important role in the laminin‐dependent development of dorsal root ganglia during chicken embryogenesis
    Authors:
    Ewa Mrówczyńska, Antonina J. Mazur
    Academic press:
    Cells (rok: 2021, tom: 10(7), strony: 45682), Wydawca: MDPI Basel
    Status:
    Published
    DOI:
    10.3390/cells10071666 - link to the publication
  2. Non-integrin laminin receptor (LamR) plays a role in axonal outgrowth from chicken DRG via modulating the Akt and Erk signaling
    Authors:
    Ewa Mrówczyńska, Karolina Machalica, Antonina Mazur
    Academic press:
    Frontiers in Cell and Developmental Biology (rok: 2024, tom: 12:1433947, strony: 17), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fcell.2024.1433947 - link to the publication
  3. Gelatin Zymography to Detect Gelatinase Activity in Melanoma Cells
    Authors:
    Ewa Mrówczyńska, Ewa Mazurkiewicz, Antonina Joanna Mazur
    Academic press:
    JoVE Journal of Visualized Experiments (rok: 2022, tom: 181, strony: 45679), Wydawca: JOURNAL OF VISUALIZED EXPERIMENTS
    Status:
    Published
    DOI:
    10.3791/63278 - link to the publication
  4. Gelsolin traps ribosomes within lipid nanodomains of the plasma membrane and modulates the level of protein synthesis in the submembranous region of human skin melanoma cells
    Authors:
    Ewa Mazurkiewicz-Stanek, Joanna Machnik, Iryna Kopernyk, Wojciech Wiertelak, Dorota Maszczak-Seneczko, Estera Jeruzalska, Agnieszka Biernatowska, Aleksandra Makowiecka, Michał Majkowski, Przemysław Biecek, Tomasz Trombik, Piotr Donizy, Antonina Mazur
    Academic press:
    BBA - Molecular Basis of Disease (rok: 2025, tom: 1871, strony: 45678), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2025.167686 - link to the publication
  5. Integrin-linked kinase (ILK): the known vs. the unknown and perspectives
    Authors:
    Agata Górska, Antonina J. Mazur
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2022, tom: 79, strony: 45683), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00018-021-04104-1 - link to the publication
  6. Gelsolin Contributes to the Motility of A375 Melanoma Cells and This Activity Is Mediated by the Fibrous Extracellular Matrix Protein Profile
    Authors:
    Ewa Mazurkiewicz, Aleksandra Makowiecka, Ewa Mrówczyńska, Iryna Kopernyk, Dorota Nowak, Antonina J. Mazur
    Academic press:
    Cells (rok: 2021, tom: 10(8), strony: 45686), Wydawca: MDPI Basel
    Status:
    Published
    DOI:
    10.3390/cells10081848 - link to the publication
  7. Isolation of Stably Transfected Melanoma Cell Clones
    Authors:
    Ewa Mazurkiewicz, Ewa Mrówczyńska, Antonina Joanna Mazur
    Academic press:
    JoVE Journal of Visualized Experiments (rok: 2022, tom: 186, strony: 45678), Wydawca: JOURNAL OF VISUALIZED EXPERIMENTS
    Status:
    Published
    DOI:
    10.3791/63371 - link to the publication
  1. A Fluorescent Gelatin Degradation Assay to Study Melanoma Breakdown of Extracellular Matrix
    Authors:
    Ewa Mazurkiewicz, Ewa Mrówczyńska, Aleksandra Simiczyjew, Dorota Nowak, Antonina J. Mazur
    Book:
    "Melanoma - methods and protocols" w serii książek "Methods in molecular biology" (rok: 2021, tom: 2265, strony: 47-63), Wydawca: Springer Nature
    Status:
    Published

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