Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Assesment of a therapeytic system: recombinant oncolytic myxoma virus and mesenchymal stem cells in experimental cancer therapy

2016/22/M/NZ6/00418

Keywords:

myxoma virus oncolytic therapy mesenchymal stem cells,melanoma glioma pancreatic cancer

Descriptors:

  • NZ6_8: Other related subjects
  • NZ5_7: Human disease treatment

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Oddział w Gliwicach

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Joanna Jazowiecka-Rakus 

Number of co-investigators in the project: 9

Call: HARMONIA 8 - announced on 2016-06-15

Amount awarded: 829 000 PLN

Project start date (Y-m-d): 2017-04-20

Project end date (Y-m-d): 2022-12-19

Project duration:: 68 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Mesenchymal stem cells as carriers for systemic delivery of oncolytic viruses
    Authors:
    Agata Hadryś, Aleksander Sochanik, Grant McFadden, Joanna Jazowiecka-Rakus
    Academic press:
    European Journal of Pharmacology (rok: 2020, tom: 874, strony: 45304), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2020.172991 - link to the publication
  2. Myxoma Virus-Loaded Mesenchymal Stem Cells in Experimental Oncolytic Therapy of Murine Pulmonary Melanoma
    Authors:
    Joanna Jazowiecka-Rakus, Aleksander Sochanik, Aleksandra Rusin, Agata Hadryś, Wojciech Fidyk, Nancy Villa, Masmudur M. Rahman, Ewa Chmielik, Lina S. Franco, Grant McFadden
    Academic press:
    Molecular Therapy - Oncolytics (rok: 2020, tom: 18, strony: 335-350), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.omto.2020.07.003 - link to the publication
  3. Myxoma Virus Expressing LIGHT (TNFSF14) Pre-Loaded into Adipose-Derived Mesenchymal Stem Cells Is Effective Treatment for Murine Pancreatic Adenocarcinoma
    Authors:
    Joanna Jazowiecka-Rakus, Agata Hadrys, Masmudur M Rahman, Grant McFadden, Wojciech Fidyk, Ewa Chmielik, Marlena Pazdzior, Maciej Grajek, Violetta Kozik, Aleksander Sochanik
    Academic press:
    Cancers (Basel) (rok: 2021, tom: 13, strony: 1394), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13061394 - link to the publication
  4. Combination of LIGHT (TNFSF14)-Armed Myxoma Virus Pre-Loaded into ADSCs and Gemcitabine in the Treatment of Experimental Orthotopic Murine Pancreatic Adenocarcinoma
    Authors:
    Joanna Jazowiecka-Rakus; Aleksander Sochanik; Agata Hadryś; Wojciech Fidyk; Ewa Chmielik; Masmudur M. Rahman; Grant McFadden
    Academic press:
    Cancers (Basel) (rok: 2022, tom: 14, strony: 2022), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers14082022 - link to the publication

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