Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Detailed mechanism of resting state membrane raft formation via dissecting the MPP1-flotillins/lipids interactions in vitro

2016/21/B/NZ1/02821

Keywords:

Membrane rafts MPP1 Flotillins Artificial model membranes Protein-protein interactions Protein-lipid interactions

Descriptors:

  • NZ1_2: Biochemistry
  • NZ1_11: Other related subjects
  • NZ3_1: Cell biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Aleksander Czogalla 

Number of co-investigators in the project: 5

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 960 480 PLN

Project start date (Y-m-d): 2017-01-12

Project end date (Y-m-d): 2021-01-11

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komora CO2 z wytrząsaniem i nawilżaniem atmosfery (90 000 PLN)
  2. Osmometr Marcel OS3000.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (3)
  1. Interaction of membrane palmitoylated protein-1 with model lipid membranes
    Authors:
    Mohamed Elderdfi, Aleksander F. Sikorski
    Academic press:
    General Physiology and Biophysics (rok: 2018, tom: 37, strony: 603–617), Wydawca: AEPress, Bratislava, Slovakia
    Status:
    Published
    DOI:
    10.4149/gpb_2018029 - link to the publication
  2. High-Level Expression of Palmitoylated MPP1 Recombinant Protein in Mammalian Cells
    Authors:
    Agnieszka Chytła, Weronika Gajdzik-Nowak, Agnieszka Biernatowska, Aleksander F. Sikorski, Aleksander Czogalla
    Academic press:
    Membranes (rok: 2021, tom: 11, strony: 715), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/membranes11090715 - link to the publication
  3. Molecular characterization of direct interactions between MPP1 and flotillins
    Authors:
    Agnieszka Biernatowska, Paulina Olszewska, Krzysztof Grzymajło, Dominik Drabik, Sebastian Kraszewski, Aleksander F. Sikorski, Aleksander Czogalla
    Academic press:
    Scientific Reports (rok: 2021, tom: 11, strony: 14751), Wydawca: NATURE RESEARCH, Berlin, Germany
    Status:
    Published
    DOI:
    10.1038/s41598-021-93982-3 - link to the publication
  4. Not Just Another Scaffolding Protein Family: The Multifaceted MPPs
    Authors:
    Agnieszka Chytła, Weronika Gajdzik-Nowak, Paulina Olszewska, Agnieszka Biernatowska , Aleksander F Sikorski, Aleksander Czogalla
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 4954), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/molecules25214954 - link to the publication
  5. MPP1 Determines the Mobility of Flotillins and Controls the Confinement of Raft-Associated Molecules
    Authors:
    Agnieszka Biernatowska, Karolina Wójtowicz, Tomasz Trombik, Aleksander F. Sikorski, Aleksander Czogalla
    Academic press:
    Cells (rok: 2022, tom: 11, strony: 311), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11030311 - link to the publication
  1. High affinity interaction of MPP1 with flotillins in vitro
    Authors:
    Paulina Olszewska, Krzysztof Grzymajło, Aleksander Czogalla, Agnieszka Biernatowska
    Conference:
    43rd FEBS Congress "Biochemistry Forever" (rok: 2018, ), Wydawca: FEBS Press and John Wiley & Sons Ltd.
    Data:
    konferencja 07-12 lipca
    Status:
    Published
  2. Mapping of MPP1 palmitoylation sites using AcylPEGExchange (APE) method
    Authors:
    W. Gajdzik-Nowak, A. Chytła, A. Biernatowska, A. Czogalla
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: FEBS Press and John Wiley & Sons Ltd.
    Data:
    konferencja 06-11.07.2019
    Status:
    Published
  3. Mapping interaction site in MPP1 for flotillins
    Authors:
    P. Olszewska, K. Grzymajło, A. Czogalla, A. Biernatowska
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: FEBS Press and John Wiley & Sons Ltd.
    Data:
    konferencja 06-11.07.2019
    Status:
    Published

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