Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Ketogenic diet in pill? Assessement of the role of NAD+/NADH ratio as a factor responsible for the antiepileptic activity of ketogenic diet.

2016/21/B/NZ7/02066

Keywords:

epilepsy ketogenic diet NAD+/NADH ratio

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Psychiatrii i Neurologii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Piotr Maciejak 

Number of co-investigators in the project: 6

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 860 860 PLN

Project start date (Y-m-d): 2017-03-02

Project end date (Y-m-d): 2022-03-01

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Wielodetekcyjny czytnik mikropłytek (np. Biotec Synergy H1MG) (195 000 PLN)
  2. Autosampler programowalny Hitachi.

Information in the final report

  • Publication in academic press/journals (4)
  1. Increased hippocampal afterdischarge threshold in ketogenic diet is accompanied by enhanced kynurenine pathway activity
    Authors:
    Bartosz Osuch, Karolina Kołosowska, Natalia Chmielewska, Danuta Turzyńska, Alicja Sobolewska, Janusz Szyndler Piotr Maciejak
    Academic press:
    Neurochemical Research (rok: 2022, tom: 47, strony: 2109–2122), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11064-022-03605-0 - link to the publication
  2. Non-pharmacological treatment of epilepsy
    Authors:
    Bartosz Osuch, Piotr Maciejak
    Academic press:
    Pharmacotherapy in Psychiatry and Neurology (rok: 2020, tom: 36 (4), strony: 313-326), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.33450/fpn.2020.11.002 - link to the publication
  3. Octanoic acid prevents reduction of striatal dopamine in the MPTP mouse model of Parkinson's disease.
    Authors:
    Joniec-Maciejak I, Wawer A, Turzyńska D, Sobolewska A, Maciejak P, Szyndler J, Mirowska-Guzel D, Płaźnik A.
    Academic press:
    Pharmacol Rep. (rok: 2018, tom: 70(5), strony: 988-992), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2018.04.008 - link to the publication
  4. Rola mitofagii w wybranych chorobach neurodegeneracyjnych
    Authors:
    Bartosz Osuch , Teresa Kucharska , Natalia Chmielewska , Piotr Maciejak , Janusz Szyndler , Adam Płaźnik
    Academic press:
    Advances in Psychiatry and Neurology/Postępy Psychiatrii i Neurologii (rok: 2019, tom: 28 (2), strony: 154-161), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.5114/ppn.2019.86258 - link to the publication

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