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Influence of bacterial and viral co-infections in the heterogeneic course of chronic lymphocytic leukemia - the role of Streptococcus pneumoniae and Epstein-Barr virus

2016/21/B/NZ6/02279

Keywords

Descriptors

  • NZ6_2: Immunologia kliniczna
  • NZ6_1: Odporność swoista i nieswoista
  • NZ6_5: Wirusologia

Panel

NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution

Uniwersytet Medyczny w Lublinie, Wydział Lekarski

Voivodeship: lubelskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Jacek Mariusz Roliński

Number of co-investigators in the project: 5

Call

OPUS 11 – announced on 2016-03-15

Amount awarded
721 305 PLN
Project start date
2017-03-08
Project end date
2022-03-07
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (17)

  1. Chronic lymphocytic leukemia-induced humoral immunosuppression: a systematic review

    Authors:
    Ewelina Grywalska, Monika Zaborek, Jakub Łyczba, Rafał Hrynkiewicz, Dominika Bębnowska, Rafał Becht, Barbara Sosnowska-Pasiarska, Jolanta Smok-Kalwat, Marcin Pasiarski, Stanisław Góźdź, Jacek Roliński, Paulina Niedźwiedzka-Rystwej
    Academic press:
    Cells (year: 2020, volume: 9(11),art.2398, pages: 46036), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9112398 – link to the publication

  2. Expression of CTLA-4 and CD86 Antigens and Epstein-Barr Virus Reactivation in Chronic Lymphocytic Leukemia—Any Link with Known Prognostic Factors?

    Authors:
    Ewelina Grywalska, Michał Mielnik, Martyna Podgajna, Anna Hymos, Jarosław Ludian, Agnieszka Rolińska, Krzysztof Gosik, Wojciech Kwaśniewski, Barbara Sosnowska-Pasiarska, Jolanta Smok-Kalwat, Marcin Pasiarski, Agnieszka Stelmach-Gołdyś, Stanisław Góźdź, Jacek Roliński
    Academic press:
    Cancers (year: 2022, volume: 14, pages: 46036), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers14030672 – link to the publication

  3. Could hemophagocytic lymphohistiocytosis be the core issue of severe COVID-19 cases?

    Authors:
    Violetta Opoka-Winiarska, Ewelina Grywalska, Jacek Roliński
    Academic press:
    BMC Medicine (year: 2020, volume: 18(1):214, pages: 46033), Publisher: BMC
    Status:
    Published
    DOI:
    10.1186/s12916-020-01682-y – link to the publication

  4. CAR-T Cell Therapy-An Overview of Targets in Gastric Cancer

    Authors:
    Dominika Bębnowska, Ewelina Grywalska, Paulina Niedźwiedzka-Rystwej, Barbara Sosnowska-Pasiarska, Jolanta Smok-Kalwat, Marcin Pasiarski, Stanisław Góźdź, Jacek Roliński, Wojciech Polkowski
    Academic press:
    Journal of Clinical Medicine (year: 2020, volume: 9(6),art.1894, pages: 46037), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm9061894 – link to the publication

  5. The Double-Edged Sword Role of Viruses in Gastric Cancer

    Authors:
    Paulina Niedźwiedzka-Rystwej, Ewelina Grywalska, Rafał Hrynkiewicz, Mikołaj Wołącewicz, Rafał Becht, Jacek Rolińsk
    Academic press:
    Cancers (year: 2020, volume: 12, pages: 46046), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12061680 – link to the publication

  6. Interferon alpha as antiviral therapy in chronic active Epstein-Barr virus disease with interstitial pneumonia – case report

    Authors:
    Jacek Roliński, Ewelina Grywalska, Michał Dzik, Aleksandra Pyzik, Agata Surdacka, Maciej Maj, Franciszek Burdan, Michał Pirożyński, Elżbieta Starosławska, Violetta Opoka-Winiarska
    Academic press:
    BMC Infectious Diseases (year: 2018, volume: 0,881944444444445, pages: 46028), Publisher: BMC
    Status:
    Published
    DOI:
    10.1186/s12879-018-3097-6 – link to the publication

  7. Immune-checkpoint inhibitors for combating T-cell dysfunction in cancer

    Authors:
    Ewelina Grywalska, Marcin Pasiarski, Stanisław Góźdź, Jacek Roliński
    Academic press:
    OncoTargets and Therapy (year: 2018, volume: 11, pages: 6505-6524), Publisher: Dove Medical Press
    Status:
    Published
    DOI:
    10.2147/OTT.S150817 – link to the publication

  8. Does the Epstein-Barr virus play a role in the pathogenesis of Graves' disease?

    Authors:
    Aleksandra Pyzik, Ewelina Grywalska, Beata Matyjaszek-Matuszek, Jarosław Ludian, Ewa Kiszczak-Bochyńska, Agata Smoleń, Jacek Roliński, Dawid Pyzik
    Academic press:
    International Journal of Molecular Sciences (year: 2019, volume: 20(13), pages: pii: E3145. doi: 10.3390/ijms20133145), Publisher: MDPI (Basel, Switzerland)
    Status:
    Published
    DOI:
    10.3390/ijms20133145 – link to the publication

  9. Current possibilities of gynecologic cancers treatment with the use of immune checkpoint inhibitors

    Authors:
    Ewelina Grywalska, Małgorzata Sobstyl, Lechosław Putowski, Jacek Roliński
    Academic press:
    International Journal of Molecular Sciences (year: 2019, volume: 20(19), pages: 4705; https://doi.org/10.3390/ijms20194705), Publisher: MDPI (Basel, Switzerland)
    Status:
    Published
    DOI:
    10.3390/ijms20194705 – link to the publication

  10. Bacterial Colonization in Patients with Chronic Lymphocytic Leukemia and Factors Associated with Infections and Colonization

    Authors:
    Izabela Korona-Glowniak, Ewelina Grywalska, Agnieszka Grzegorczyk, Jacek Roliński, Andrzej Glowniak, Anna Malm
    Academic press:
    Journal of Clinical Medicine (year: 2019, volume: 8(6), pages: 8(6). pii: E861. doi: 10.3390/jcm8060861), Publisher: MDPI (Basel, Switzerland)
    Status:
    Published
    DOI:
    10.3390/jcm8060861 – link to the publication

  11. Effectiveness of Haemophilus influenzae type b vaccination after splenectomy - impact on selected immunological parameters

    Authors:
    Ewelina Grywalska, Dorota Siwicka-Gieroba, Michał Mielnik, Martyna Podgajna, Krzysztof Gosik, Wojciech Dąbrowski, Jacek Roliński
    Academic press:
    Human Vaccines & Immunotherapeutics (year: 2018, volume: 0,626388888888889, pages: 339-348), Publisher: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1080/21645515.2018.1537744 – link to the publication

  12. Peripheral blood T lymphocytes are downregulated by the PD-1/PD-L1 axis in advanced gastric cancer

    Authors:
    Witold Zgodzinski, Ewelina Grywalska, Krzysztof Zinkiewicz, Agata Surdacka, Marek Majewski, Artur Zakoscielny, Pawel Bury, Jacek Rolinski, Grzegorz T. Wallner
    Academic press:
    Archives of Medical Science (year: 2018, volume: ID 87024, pages: 46032), Publisher: Termedia
    Status:
    Published
    DOI:
    10.5114/aoms.2018.75092 – link to the publication

  13. Immunotherapy in Bladder Cancer: Current Methods and Future Perspectives

    Authors:
    Mikołaj Wołącewicz, Rafał Hrynkiewicz, Ewelina Grywalska, Tomasz Suchojad, Tomasz Leksowski, Jacek Roliński, Paulina Niedźwiedzka-Rystwej
    Academic press:
    Cancers (year: 2020, volume: 12(5),art.1181, pages: 46039), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12051181 – link to the publication

  14. Relationship between the expression of CD25 and CD69 on the surface of lymphocytes T and B from peripheral blood and bone marrow of patients with chronic lymphocytic leukemia and established prognostic factors of this disease

    Authors:
    Ewelina Grywalska, Małgorzata Bartkowiak-Emeryk, Marcin Pasiarski, Karolina Olszewska-Bożek, Michał Mielnik, Martyna Podgajna, Monika Pieczykolan, Anna Hymos, Elżbieta Fitas, Agata Surdacka, Stanisław Góźdź, Jacek Roliński
    Academic press:
    Advances in Clinical and Experimental Medicine (year: 2018, volume: 27(7), pages: 987-999), Publisher: Wroclaw Medical University
    Status:
    Published
    DOI:
    10.17219/acem/74437 – link to the publication

  15. ThymicPeptides Reverse Immune Exhaustion in Patients with Reactivated Human Alphaherpesvirus1 Infections

    Authors:
    Anna Hymos, Ewelina Grywalska, Janusz Klatka, Maria Klatka, Izabela Korona-Głowniak, Jacek Roliński
    Academic press:
    International Journal of Molecular Sciences (year: 2020, volume: 21(7),art.2379, pages: 46034), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21072379 – link to the publication

  16. Programmed cell death 1 expression and Epstein-Barr virus infection in chronic lymphocytic leukaemia: a prospective cohort study

    Authors:
    Ewelina Grywalska, Marcin Pasiarski, Barbara Sosnowska-Pasiarska, Paweł Macek, Agnieszka Rolińska, Marzena Samardakiewicz, Jarosław Ludian, Stanisław Góźdź, Jacek Roliński
    Academic press:
    Cancer Management and Research (year: 2019, volume: 11, pages: 7605-7618), Publisher: Dovepress
    Status:
    Published
    DOI:
    10.2147/CMAR.S212069 – link to the publication

  17. Immunogenicity and safety of the 13-valent pneumococcal conjugate vaccine in patients with monoclonal gammopathy of undetermined significance – relationship with selected immune and clinical parameters

    Authors:
    Marcin Pasiarski,Barbara Sosnowska-Pasiarska, Ewelina Grywalska, Agnieszka Stelmach-Gołdyś, Artur Kowalik, Stanisław Góźdź, Jacek Roliński
    Academic press:
    Clinical Interventions in Aging (year: 2019, volume: 14, pages: 1741–1749), Publisher: Dovepress
    Status:
    Published
    DOI:
    10.2147/CIA.S220423 – link to the publication

Articles in post-conference publications (3)

  1. MYELOID AND LYMPHOID DENDRITIC CELLS IN PATIENTS WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE - POSSIBLE LINK WITH DISEASE PROGRESSION

    Authors:
    Ewelina Grywalska, Marcin Pasiarski, Agnieszka Stelmach-Goldys, Barbara Sosnowska-Pasiarska, Pawel Steckiewicz, Anna Kowalska, Krzysztof Gosik, Bartosz Garus, Stanislaw Gozdz, Jacek Rolinski
    Conference:
    23rd Congress of the European Hematology Association (year: 2018, pages: https://journals.lww.com/hemasphere/toc/2018/06001), Publisher: European Hematology Association
    Date:
    conference 14-17.06.2018
    Status:
    Published

  2. ASSESSMENT OF SELECTED TOLL-LIKE RECEPTORS EXPRESSION ONT AND B LYMPHOCYTES IN PATIENTS WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE

    Authors:
    Ewelina Grywalska, Marcin Pasiarski, Pawel Steckiewicz, Agnieszka Stelmach-Goldys, Barbara Sosnowska- Pasiarska, Krzysztof Gosik, Anna Kowalska, Bartosz Garus, Stanislaw Gozdz, Jacek Rolinski
    Conference:
    23rd Congress of the European Hematology Association (year: 2018, pages: https://journals.lww.com/hemasphere/toc/2018/06001), Publisher: European Hematology Association
    Date:
    conference 14-17.06.2018
    Status:
    Published

  3. THE CORRELATION OF PD-1/PD-L1 SIGNALLING PATHWAY AND EPSTEIN-BARR VIRUS COINFECTION IN PATIENTS SUFFERING FROM CHRONIC LYMPHOCYTIC LEUKEMIA

    Authors:
    Martyna Podgajna, Michał Mielnik, Mateusz Mielnik, Ewelina Grywalska
    Conference:
    6th Lublin International Medical Congress for Students and Young Doctors (year: 2019, pages: 99), Publisher: Uniwersytet Medyczny w Lublinie
    Date:
    conference 28-30.11.2019
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski