Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Influence of bacterial and viral co-infections in the heterogeneic course of chronic lymphocytic leukemia - the role of Streptococcus pneumoniae and Epstein-Barr virus

2016/21/B/NZ6/02279

Keywords:

Epstein-Barr virus Streptococcus pneumoniae chronic lymphocytic leukemia

Descriptors:

  • NZ6_2: Clinical immunology
  • NZ6_1: Adaptive and innate immunity
  • NZ6_5: Virology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Lekarski

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jacek Roliński 

Number of co-investigators in the project: 5

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 721 305 PLN

Project start date (Y-m-d): 2017-03-08

Project end date (Y-m-d): 2022-03-07

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (17)
  • Articles in post-conference publications (3)
  1. CAR-T Cell Therapy-An Overview of Targets in Gastric Cancer
    Authors:
    Dominika Bębnowska, Ewelina Grywalska, Paulina Niedźwiedzka-Rystwej, Barbara Sosnowska-Pasiarska, Jolanta Smok-Kalwat, Marcin Pasiarski, Stanisław Góźdź, Jacek Roliński, Wojciech Polkowski
    Academic press:
    Journal of Clinical Medicine (rok: 2020, tom: 9(6),art.1894, strony: 45306), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm9061894 - link to the publication
  2. Peripheral blood T lymphocytes are downregulated by the PD-1/PD-L1 axis in advanced gastric cancer
    Authors:
    Witold Zgodzinski, Ewelina Grywalska, Krzysztof Zinkiewicz, Agata Surdacka, Marek Majewski, Artur Zakoscielny, Pawel Bury, Jacek Rolinski, Grzegorz T. Wallner
    Academic press:
    Archives of Medical Science (rok: 2018, tom: ID 87024, strony: 45301), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.5114/aoms.2018.75092 - link to the publication
  3. Programmed cell death 1 expression and Epstein-Barr virus infection in chronic lymphocytic leukaemia: a prospective cohort study
    Authors:
    Ewelina Grywalska, Marcin Pasiarski, Barbara Sosnowska-Pasiarska, Paweł Macek, Agnieszka Rolińska, Marzena Samardakiewicz, Jarosław Ludian, Stanisław Góźdź, Jacek Roliński
    Academic press:
    Cancer Management and Research (rok: 2019, tom: 11, strony: 7605-7618), Wydawca: Dovepress
    Status:
    Published
    DOI:
    10.2147/CMAR.S212069 - link to the publication
  4. Bacterial Colonization in Patients with Chronic Lymphocytic Leukemia and Factors Associated with Infections and Colonization
    Authors:
    Izabela Korona-Glowniak, Ewelina Grywalska, Agnieszka Grzegorczyk, Jacek Roliński, Andrzej Glowniak, Anna Malm
    Academic press:
    Journal of Clinical Medicine (rok: 2019, tom: 8(6), strony: 8(6). pii: E861. doi: 10.3390/jcm8060861), Wydawca: MDPI (Basel, Switzerland)
    Status:
    Published
    DOI:
    10.3390/jcm8060861 - link to the publication
  5. Chronic lymphocytic leukemia-induced humoral immunosuppression: a systematic review
    Authors:
    Ewelina Grywalska, Monika Zaborek, Jakub Łyczba, Rafał Hrynkiewicz, Dominika Bębnowska, Rafał Becht, Barbara Sosnowska-Pasiarska, Jolanta Smok-Kalwat, Marcin Pasiarski, Stanisław Góźdź, Jacek Roliński, Paulina Niedźwiedzka-Rystwej
    Academic press:
    Cells (rok: 2020, tom: 9(11),art.2398, strony: 45305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9112398 - link to the publication
  6. Current possibilities of gynecologic cancers treatment with the use of immune checkpoint inhibitors
    Authors:
    Ewelina Grywalska, Małgorzata Sobstyl, Lechosław Putowski, Jacek Roliński
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20(19), strony: 4705; https://doi.org/10.3390/ijms20194705), Wydawca: MDPI (Basel, Switzerland)
    Status:
    Published
    DOI:
    10.3390/ijms20194705 - link to the publication
  7. Relationship between the expression of CD25 and CD69 on the surface of lymphocytes T and B from peripheral blood and bone marrow of patients with chronic lymphocytic leukemia and established prognostic factors of this disease
    Authors:
    Ewelina Grywalska, Małgorzata Bartkowiak-Emeryk, Marcin Pasiarski, Karolina Olszewska-Bożek, Michał Mielnik, Martyna Podgajna, Monika Pieczykolan, Anna Hymos, Elżbieta Fitas, Agata Surdacka, Stanisław Góźdź, Jacek Roliński
    Academic press:
    Advances in Clinical and Experimental Medicine (rok: 2018, tom: 27(7), strony: 987-999), Wydawca: Wroclaw Medical University
    Status:
    Published
    DOI:
    10.17219/acem/74437 - link to the publication
  8. The Double-Edged Sword Role of Viruses in Gastric Cancer
    Authors:
    Paulina Niedźwiedzka-Rystwej, Ewelina Grywalska, Rafał Hrynkiewicz, Mikołaj Wołącewicz, Rafał Becht, Jacek Rolińsk
    Academic press:
    Cancers (rok: 2020, tom: 12, strony: 45315), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12061680 - link to the publication
  9. Immunogenicity and safety of the 13-valent pneumococcal conjugate vaccine in patients with monoclonal gammopathy of undetermined significance – relationship with selected immune and clinical parameters
    Authors:
    Marcin Pasiarski,Barbara Sosnowska-Pasiarska, Ewelina Grywalska, Agnieszka Stelmach-Gołdyś, Artur Kowalik, Stanisław Góźdź, Jacek Roliński
    Academic press:
    Clinical Interventions in Aging (rok: 2019, tom: 14, strony: 1741–1749), Wydawca: Dovepress
    Status:
    Published
    DOI:
    10.2147/CIA.S220423 - link to the publication
  10. Could hemophagocytic lymphohistiocytosis be the core issue of severe COVID-19 cases?
    Authors:
    Violetta Opoka-Winiarska, Ewelina Grywalska, Jacek Roliński
    Academic press:
    BMC Medicine (rok: 2020, tom: 18(1):214, strony: 45302), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12916-020-01682-y - link to the publication
  11. Does the Epstein-Barr virus play a role in the pathogenesis of Graves' disease?
    Authors:
    Aleksandra Pyzik, Ewelina Grywalska, Beata Matyjaszek-Matuszek, Jarosław Ludian, Ewa Kiszczak-Bochyńska, Agata Smoleń, Jacek Roliński, Dawid Pyzik
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20(13), strony: pii: E3145. doi: 10.3390/ijms20133145), Wydawca: MDPI (Basel, Switzerland)
    Status:
    Published
    DOI:
    10.3390/ijms20133145 - link to the publication
  12. Immunotherapy in Bladder Cancer: Current Methods and Future Perspectives
    Authors:
    Mikołaj Wołącewicz, Rafał Hrynkiewicz, Ewelina Grywalska, Tomasz Suchojad, Tomasz Leksowski, Jacek Roliński, Paulina Niedźwiedzka-Rystwej
    Academic press:
    Cancers (rok: 2020, tom: 12(5),art.1181, strony: 45308), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12051181 - link to the publication
  13. ThymicPeptides Reverse Immune Exhaustion in Patients with Reactivated Human Alphaherpesvirus1 Infections
    Authors:
    Anna Hymos, Ewelina Grywalska, Janusz Klatka, Maria Klatka, Izabela Korona-Głowniak, Jacek Roliński
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21(7),art.2379, strony: 45303), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21072379 - link to the publication
  14. Effectiveness of Haemophilus influenzae type b vaccination after splenectomy - impact on selected immunological parameters
    Authors:
    Ewelina Grywalska, Dorota Siwicka-Gieroba, Michał Mielnik, Martyna Podgajna, Krzysztof Gosik, Wojciech Dąbrowski, Jacek Roliński
    Academic press:
    Human Vaccines & Immunotherapeutics (rok: 2018, tom: 0,626388888888889, strony: 339-348), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1080/21645515.2018.1537744 - link to the publication
  15. Expression of CTLA-4 and CD86 Antigens and Epstein-Barr Virus Reactivation in Chronic Lymphocytic Leukemia—Any Link with Known Prognostic Factors?
    Authors:
    Ewelina Grywalska, Michał Mielnik, Martyna Podgajna, Anna Hymos, Jarosław Ludian, Agnieszka Rolińska, Krzysztof Gosik, Wojciech Kwaśniewski, Barbara Sosnowska-Pasiarska, Jolanta Smok-Kalwat, Marcin Pasiarski, Agnieszka Stelmach-Gołdyś, Stanisław Góźdź, Jacek Roliński
    Academic press:
    Cancers (rok: 2022, tom: 14, strony: 45305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers14030672 - link to the publication
  16. Immune-checkpoint inhibitors for combating T-cell dysfunction in cancer
    Authors:
    Ewelina Grywalska, Marcin Pasiarski, Stanisław Góźdź, Jacek Roliński
    Academic press:
    OncoTargets and Therapy (rok: 2018, tom: 11, strony: 6505-6524), Wydawca: Dove Medical Press
    Status:
    Published
    DOI:
    10.2147/OTT.S150817 - link to the publication
  17. Interferon alpha as antiviral therapy in chronic active Epstein-Barr virus disease with interstitial pneumonia – case report
    Authors:
    Jacek Roliński, Ewelina Grywalska, Michał Dzik, Aleksandra Pyzik, Agata Surdacka, Maciej Maj, Franciszek Burdan, Michał Pirożyński, Elżbieta Starosławska, Violetta Opoka-Winiarska
    Academic press:
    BMC Infectious Diseases (rok: 2018, tom: 0,881944444444445, strony: 45297), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12879-018-3097-6 - link to the publication
  1. ASSESSMENT OF SELECTED TOLL-LIKE RECEPTORS EXPRESSION ONT AND B LYMPHOCYTES IN PATIENTS WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE
    Authors:
    Ewelina Grywalska, Marcin Pasiarski, Pawel Steckiewicz, Agnieszka Stelmach-Goldys, Barbara Sosnowska- Pasiarska, Krzysztof Gosik, Anna Kowalska, Bartosz Garus, Stanislaw Gozdz, Jacek Rolinski
    Conference:
    23rd Congress of the European Hematology Association (rok: 2018, ), Wydawca: European Hematology Association
    Data:
    konferencja 14-17.06.2018
    Status:
    Published
  2. THE CORRELATION OF PD-1/PD-L1 SIGNALLING PATHWAY AND EPSTEIN-BARR VIRUS COINFECTION IN PATIENTS SUFFERING FROM CHRONIC LYMPHOCYTIC LEUKEMIA
    Authors:
    Martyna Podgajna, Michał Mielnik, Mateusz Mielnik, Ewelina Grywalska
    Conference:
    6th Lublin International Medical Congress for Students and Young Doctors (rok: 2019, ), Wydawca: Uniwersytet Medyczny w Lublinie
    Data:
    konferencja 28-30.11.2019
    Status:
    Published
  3. MYELOID AND LYMPHOID DENDRITIC CELLS IN PATIENTS WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE - POSSIBLE LINK WITH DISEASE PROGRESSION
    Authors:
    Ewelina Grywalska, Marcin Pasiarski, Agnieszka Stelmach-Goldys, Barbara Sosnowska-Pasiarska, Pawel Steckiewicz, Anna Kowalska, Krzysztof Gosik, Bartosz Garus, Stanislaw Gozdz, Jacek Rolinski
    Conference:
    23rd Congress of the European Hematology Association (rok: 2018, ), Wydawca: European Hematology Association
    Data:
    konferencja 14-17.06.2018
    Status:
    Published

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