Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Interplay of posttranslational redox cysteine modifications and metal ion binding as key to conformational and functional plasticity of innate immunity and cancer biomarkers - S100A8 and S100A9 proteins

2016/21/B/NZ1/02788

Keywords:

S100A8 S100A9 nitrosylation posttranslational cysteine modifictions metalloproteins mass spectrometry

Descriptors:

  • NZ1_3: Biophysics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Aleksandra Wysłouch-Cieszyńska 

Number of co-investigators in the project: 10

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 033 600 PLN

Project start date (Y-m-d): 2017-03-02

Project end date (Y-m-d): 2022-09-01

Project duration:: 66 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Dwa zestawy komputerowe z monitorami, dyskami do przechowywania kopii zapasowych, UPS i oprogramowaniem zawierającym program kalkulacyjny Origin (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Vimentin S-glutathionylation at Cys328 inhibits filament elongation and induces severing of mature filaments in vitro
    Authors:
    Magdalena Kaus-Drobek, Norbert Mucke, Roman H. Szczepanowski, Tatjana Wedig, Mariusz Czarnocki- Cieciura, Magdalena Polakowska, Harald Herrmann, Aleksandra Wysłouch-Cieszynska, Michał Dadlez
    Academic press:
    The FEBS Journal (rok: 2020, tom: 287(24), strony: 5304-5322), Wydawca: John Wiley & Sons
    Status:
    Published
    DOI:
    10.1111/febs.15321 - link to the publication
  2. ntracellular Protein S-Nitrosylation-A Cells Response to Extracellular S100B and RAGE Receptor
    Authors:
    Monika Zaręba-Kozioł, Michał Burdukiewicz, Aleksandra Wysłouch-Cieszyńska
    Academic press:
    Biomolecules (rok: 2022, tom: 12(5), strony: 613-625), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom12050613 - link to the publication
  3. Toward an understanding of the conformational plasticity of S100A8 and S100A9 Ca2+-binding proteins
    Authors:
    Magdalena Polakowska, Kamil Steczkiewicz, Roman H Szczepanowski, Aleksandra Wysłouch-Cieszyńska
    Academic press:
    Journal of Biological Chemistry (rok: 2023, tom: 299(4), strony: 102952), Wydawca: Elsevier
    Status:
    Published