Projects funded by the NCN
Interplay of posttranslational redox cysteine modifications and metal ion binding as key to conformational and functional plasticity of innate immunity and cancer biomarkers - S100A8 and S100A9 proteins
2016/21/B/NZ1/02788
Keywords:
S100A8 S100A9 nitrosylation posttranslational cysteine modifictions metalloproteins mass spectrometry
Descriptors:
- NZ1_3: Biophysics
Panel:
NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution :
Instytut Biochemii i Biofizyki Polskiej Akademii Nauk
woj. mazowieckie
Principal investigator (from the host institution):
dr Aleksandra Wysłouch-Cieszyńska
Number of co-investigators in the project: 10
Call: OPUS 11 - announced on 2016-03-15
Amount awarded: 1 033 600 PLN
Project start date (Y-m-d): 2017-03-02
Project end date (Y-m-d): 2022-09-01
Project duration:: 66 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Dwa zestawy komputerowe z monitorami, dyskami do przechowywania kopii zapasowych, UPS i oprogramowaniem zawierającym program kalkulacyjny Origin (30 000 PLN)
Information in the final report
- Publication in academic press/journals (3)
- Vimentin S-glutathionylation at Cys328 inhibits filament elongation and induces severing of mature filaments in vitroAuthors:Magdalena Kaus-Drobek, Norbert Mucke, Roman H. Szczepanowski, Tatjana Wedig, Mariusz Czarnocki- Cieciura, Magdalena Polakowska, Harald Herrmann, Aleksandra Wysłouch-Cieszynska, Michał DadlezAcademic press:The FEBS Journal (rok: 2020, tom: 287(24), strony: 5304-5322), Wydawca: John Wiley & SonsStatus:PublishedDOI:10.1111/febs.15321 - link to the publication
- ntracellular Protein S-Nitrosylation-A Cells Response to Extracellular S100B and RAGE ReceptorAuthors:Monika Zaręba-Kozioł, Michał Burdukiewicz, Aleksandra Wysłouch-CieszyńskaAcademic press:Biomolecules (rok: 2022, tom: 12(5), strony: 613-625), Wydawca: MDPIStatus:PublishedDOI:10.3390/biom12050613 - link to the publication
- Toward an understanding of the conformational plasticity of S100A8 and S100A9 Ca2+-binding proteinsAuthors:Magdalena Polakowska, Kamil Steczkiewicz, Roman H Szczepanowski, Aleksandra Wysłouch-CieszyńskaAcademic press:Journal of Biological Chemistry (rok: 2023, tom: 299(4), strony: 102952), Wydawca: ElsevierStatus:PublishedDOI:Toward - link to the publication