Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Contribution of glutaminergic NMDA receptor to the mechanisms of nanosilver neurotoxicity in vivo

2016/21/B/NZ7/02756

Keywords:

silver nanoparticles neurotoxicity glutaminergic NMDA receptors excitotoxicity neurodegeneration

Descriptors:

  • NZ7_15: Toxicology
  • NZ7_2: Environment and health risks

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Lidia Strużyńska 

Number of co-investigators in the project: 7

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 689 000 PLN

Project start date (Y-m-d): 2017-02-14

Project end date (Y-m-d): 2020-12-13

Project duration:: 46 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Przystawka do zautomatyzowanego systemu do analizy RNA (6 500 PLN)
  2. Zamrażarka laboratoryjna niskotemperaturowa (37 000 PLN)
  3. zestaw komputerowy (7 000 PLN)
  4. Komora do PCR UVC/T-M-AR (12 000 PLN)
  5. Zautomatyzowany system do analizy RNA, DNA i białek (75 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (1)
  1. Response of immature rats to a low dose of nanoparticulate silver: alterations in behavior, cerebral vasculature-related transcriptome and permeability.
    Authors:
    Beata Dąbrowska-Bouta, Grzegorz Sulkowski, Jolanta Orzelska-Górka, Ewa Kędzierska, Grażyna Biała, Lidia Strużyńska
    Academic press:
    Ecotoxicology and Environmental Safety (rok: 2021, tom: 208, strony: 111416), Wydawca: Elsevier Science BV
    Status:
    Published
    DOI:
    10.1016/j.ecoenv.2020.111416k - link to the publication
  2. Early and delayed impact of nanosilver on the glutamatergic NMDA receptor complex in immature rat brain
    Authors:
    Beata Dąbrowska-Bouta, Grzegorz Sulkowski, Mikołaj Sałek, Małgorzata Frontczak-Baniewicz, Lidia Strużyńska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 3067), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22063067 - link to the publication
  3. Early postnatal exposure to a low dose of nanoparticulate silver induces alterations in glutamate transporters in brain of immature rats
    Authors:
    Beata Dąbrowska-Bouta, Grzegorz Sulkowski, Mikołaj Sałek, Magdalena Gewartowska, Marta Sidoryk- Węgrzynowicz and Lidia Strużyńska
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 8977), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21238977 - link to the publication
  1. Expression of glutamate transporters and glutamate NMDA receptor in brain of rats exposed developmentally to a low dose of silver nanoparticles.
    Authors:
    Salek M., Sulkowski G., Dabrowska-Bouta B., Struzynska L.
    Conference:
    The 14th International Symposium Molecular basis of pathology and therapy in neurological disorders". (rok: 2018, ), Wydawca: Termedia Publishing House
    Data:
    konferencja 25-26 pażdziernika
    Status:
    Published

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