Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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New Stymuli-Responsive Copolymers for Smart Drug Delivery Systems

2016/21/B/ST5/01365

Keywords:

steroidal polymers controlled radical polymerization stimuli-responsive polymers smart drug delivery systems

Descriptors:

  • ST5_12: Methods of nanomaterials/materials synthesis
  • ST5_21:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet w Białymstoku, Wydział Chemii

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Wilczewska 

Number of co-investigators in the project: 9

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 766 930 PLN

Project start date (Y-m-d): 2017-02-23

Project end date (Y-m-d): 2021-02-22

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Mieszadło mechaniczne.
  2. Liofilizator (70 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  1. Synergistic effect of folate-conjugated thermosensitive polymers and 5-fluorouracil in the treatment of colon cancer
    Authors:
    G. Siemiaszko, K. Niemirowicz-Laskowska, K. H. Markiewicz, I. Misztalewska-Turkowicz, E. Dudź, S. Milewska, P. Misiak, I. Kurowska, A. Sadowska, H. Car, A. Z. Wilczewska
    Academic press:
    Cancer Nanotechnology (rok: 2021, tom: 0,521527777777778, strony: 31), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12645-021-00104-9 - link to the publication
  2. Doxorubicin delivery systems with an acetylacetone-based block in cholesterol-terminated copolymers: diverse activity against estrogen-dependent and estrogen-independent breast cancer cells
    Authors:
    Paweł Misiak, Katarzyna Niemirowicz-Laskowska, Iwona Misztalewska-Turkowicz, Karolina H. Markiewicz, Przemysław Wielgat, Halina Car, Agnieszka Z. Wilczewska
    Academic press:
    Chemistry and Physics of Lipids (rok: 2022, tom: 245, strony: 105194), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.chemphyslip.2022.105194 - link to the publication
  3. Polymeric Drug Delivery Systems Bearing Cholesterol Moieties: A Review
    Authors:
    P. Misiak, K. H. Markiewicz, D. Szymczuk, A.Z. Wilczewska
    Academic press:
    Polymers (rok: 2020, tom: 12(11), strony: 2260), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/polym12112620 - link to the publication
  4. Magnetic particles with polymeric shells bearing cholesterol moieties sensitize breast cancer cells to low dose of doxorubicin
    Authors:
    K. H. Markiewicz, K. Niemirowicz-Laskowska, D. Szymczuk, K. Makarewicz, I. Misztalewska-Turkowicz, P. Wielgat, A. M. Majcher-Fitas, S. Kowalewska, H. Car, A.Z. Wilczewska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 4898), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094898 - link to the publication
  5. Membrane active diacylglycerol-terminated thermoresponsive polymers: RAFT synthesis and biocompatibility evaluation
    Authors:
    Izabela Kurowska, Karolina H. Markiewicz, Katarzyna Niemirowicz-Laskowska, Mathias Destac, Przemysław Wielgat, Iwona Misztalewska-Turkowicz, Paweł Misiak, Gabriela Siemiaszkoa Halina Car, Agnieszka Z. Wilczewska
    Academic press:
    European Polymer Journal (rok: 2022, tom: 169, strony: 111154), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.eurpolymj.2022.111154 - link to the publication
  6. Doxorubicin-loaded polymeric nanoparticles containing ketoester-based block and cholesterol moiety as a specific vehicle to fight estrogen-dependent breast cancer
    Authors:
    Paweł Misiak, Katarzyna Niemirowicz-Laskowska, Karolina H. Markiewicz, Przemysław Wielgat, Izabela Kurowska, Robert Czarnomysy, Iwona Misztalewska-Turkowicz, Halina Car, Krzysztof Bielawski, Agnieszka Z. Wilczewska
    Academic press:
    Cancer Nanotechnology , Wydawca: Springer Nature
    Status:
    Submitted
    DOI:
    brak - link to the publication
  7. Current Trends and Challenges in Pharmacoeconomic aspects of nanocarriers as drug delivery systems for cancer treatment
    Authors:
    S. Milewska, K. Niemirowicz-Laskowska, G. Siemiaszko, P. Nowicki, A.Z. Wilczewska, H. Car
    Academic press:
    International Journal of Nanomedicine (rok: 2021, tom: 16, strony: 6593-6644), Wydawca: Dove Medical Press
    Status:
    Published
    DOI:
    10.2147/IJN.S323831 - link to the publication
  8. Evaluation of Cytotoxic Effect of Cholesterol End-Capped Poly(N-Isopropylacrylamide)s on Selected Normal and Neoplastic Cells
    Authors:
    P. Misiak, K. Niemirowicz-Laskowska, K,. Markiewicz, I. Misztalewska-Turkowicz, P. Wielgat, I. Kurowska, G. Siemiaszko, M. Destarac, H. Car, A.Z. Wilczewska
    Academic press:
    International Journal of Nanomedicine (rok: 2020, tom: 15, strony: 7263-7278), Wydawca: Dove Medical Press
    Status:
    Published
    DOI:
    10.2147/IJN.S262582 - link to the publication
  9. Magnetic nanoparticles bearing metallocarbonyl moiety as antibacterial and antifungal agents
    Authors:
    A.Z. Wilczewska, A. Kosińska, I. Misztalewska-Turkowicz, A. Kubicka, K. Niemirowicz-Laskowska, K.H. Markiewicz, R. Bucki, G. Celichowski, B. Kalska-Szostko, B. Rudolf
    Academic press:
    Applied Surface Science (rok: 2019, tom: 487, strony: 601-609), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.apsusc.2019.05.159 - link to the publication

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