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New Stymuli-Responsive Copolymers for Smart Drug Delivery Systems

2016/21/B/ST5/01365

Keywords

Descriptors

  • ST5_12: Materiały "inteligentne" – materiały samoorganizujące się, materiały reagujące na bodźce zewnętrzne
  • ST5_21: Chemia polimerów
  • ST5_23: Chemia organiczna

Panel

ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution

Uniwersytet w Białymstoku, Wydział Chemii

Voivodeship: podlaskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Agnieszka Zofia Wilczewska

Number of co-investigators in the project: 9

Call

OPUS 11 – announced on 2016-03-15

Amount awarded
766 930 PLN
Project start date
2017-02-23
Project end date
2021-02-22
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Liofilizator. Cost: 70 000 PLN
  2. Mieszadło mechaniczne.

Information in the final report

Publication in academic press/journals (8)

  1. Magnetic particles with polymeric shells bearing cholesterol moieties sensitize breast cancer cells to low dose of doxorubicin

    Authors:
    K. H. Markiewicz, K. Niemirowicz-Laskowska, D. Szymczuk, K. Makarewicz, I. Misztalewska-Turkowicz, P. Wielgat, A. M. Majcher-Fitas, S. Kowalewska, H. Car, A.Z. Wilczewska
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 4898), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094898 – link to the publication

  2. Evaluation of Cytotoxic Effect of Cholesterol End-Capped Poly(N-Isopropylacrylamide)s on Selected Normal and Neoplastic Cells

    Authors:
    P. Misiak, K. Niemirowicz-Laskowska, K,. Markiewicz, I. Misztalewska-Turkowicz, P. Wielgat, I. Kurowska, G. Siemiaszko, M. Destarac, H. Car, A.Z. Wilczewska
    Academic press:
    International Journal of Nanomedicine (year: 2020, volume: 15, pages: 7263-7278), Publisher: Dove Medical Press
    Status:
    Published
    DOI:
    10.2147/IJN.S262582 – link to the publication

  3. Current Trends and Challenges in Pharmacoeconomic aspects of nanocarriers as drug delivery systems for cancer treatment

    Authors:
    S. Milewska, K. Niemirowicz-Laskowska, G. Siemiaszko, P. Nowicki, A.Z. Wilczewska, H. Car
    Academic press:
    International Journal of Nanomedicine (year: 2021, volume: 16, pages: 6593-6644), Publisher: Dove Medical Press
    Status:
    Published
    DOI:
    10.2147/IJN.S323831 – link to the publication

  4. Synergistic effect of folate-conjugated thermosensitive polymers and 5-fluorouracil in the treatment of colon cancer

    Authors:
    G. Siemiaszko, K. Niemirowicz-Laskowska, K. H. Markiewicz, I. Misztalewska-Turkowicz, E. Dudź, S. Milewska, P. Misiak, I. Kurowska, A. Sadowska, H. Car, A. Z. Wilczewska
    Academic press:
    Cancer Nanotechnology (year: 2021, volume: 0,521527777777778, pages: 31), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12645-021-00104-9 – link to the publication

  5. Magnetic nanoparticles bearing metallocarbonyl moiety as antibacterial and antifungal agents

    Authors:
    A.Z. Wilczewska, A. Kosińska, I. Misztalewska-Turkowicz, A. Kubicka, K. Niemirowicz-Laskowska, K.H. Markiewicz, R. Bucki, G. Celichowski, B. Kalska-Szostko, B. Rudolf
    Academic press:
    Applied Surface Science (year: 2019, volume: 487, pages: 601-609), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.apsusc.2019.05.159 – link to the publication

  6. Membrane active diacylglycerol-terminated thermoresponsive polymers: RAFT synthesis and biocompatibility evaluation

    Authors:
    Izabela Kurowska, Karolina H. Markiewicz, Katarzyna Niemirowicz-Laskowska, Mathias Destac, Przemysław Wielgat, Iwona Misztalewska-Turkowicz, Paweł Misiak, Gabriela Siemiaszkoa Halina Car, Agnieszka Z. Wilczewska
    Academic press:
    European Polymer Journal (year: 2022, volume: 169, pages: 111154), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.eurpolymj.2022.111154 – link to the publication

  7. Doxorubicin delivery systems with an acetylacetone-based block in cholesterol-terminated copolymers: diverse activity against estrogen-dependent and estrogen-independent breast cancer cells

    Authors:
    Paweł Misiak, Katarzyna Niemirowicz-Laskowska, Iwona Misztalewska-Turkowicz, Karolina H. Markiewicz, Przemysław Wielgat, Halina Car, Agnieszka Z. Wilczewska
    Academic press:
    Chemistry and Physics of Lipids (year: 2022, volume: 245, pages: 105194), Publisher: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.chemphyslip.2022.105194 – link to the publication

  8. Polymeric Drug Delivery Systems Bearing Cholesterol Moieties: A Review

    Authors:
    P. Misiak, K. H. Markiewicz, D. Szymczuk, A.Z. Wilczewska
    Academic press:
    Polymers (year: 2020, volume: 12(11), pages: 2260), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/polym12112620 – link to the publication

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Graphic design and implementation: Jakub Piotrowski