Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Modulation of the expression and activation of transcription factors Nrf2 and NF-kappaB by new synthetic triterpenoids and their conjugates potential chempreventive and therapeutic agents

2016/21/B/NZ7/01758

Keywords:

Nrf2 NF-kappaB triterpenoids chemoprevention liver and pancreas cancers

Descriptors:

  • NZ7_12: Prevention of human diseases
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Wanda Baer-Dubowska 

Number of co-investigators in the project: 7

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 941 800 PLN

Project start date (Y-m-d): 2017-02-14

Project end date (Y-m-d): 2021-11-13

Project duration:: 57 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer z oprogramowaniem do analizy statystycznej (4 500 PLN)
  2. Stacja robocza do analizy stężenia białka z wykorzystaniem spektroskopii IR oraz opartej na wzbudzeniu fluorescencyjnym analizy mutipleksowej.
  3. Analizator komórek Muse (TM) (55 000 PLN)
  4. Analizator systemowy Chemi DocTM (140 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (12)
  1. Activation of the Nrf2 response by oleanolic acid oxime morpholide (3-hydroxyiminoolean-12-en-28-oic acid morpholide) is associated with its ability to induce apoptosis and inhibit proliferation in HepG2 hepatoma cells
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Robert Kleszcz, Barbara Bednarczyk-Cwynar, Hanna Szaefer, Wanda Baer-Dubowska
    Academic press:
    European Journal of Pharmacology (rok: 2020, tom: 883, strony: art.173307 str 1-11), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2020.173307 - link to the publication
  2. Anti-Cancer Potential of Synthetic Oleanolic Acid Derivatives and Their Conjugates with NSAIDs
    Authors:
    Wanda Baer-Dubowska, Maria Narożna, Violetta Krajka-Kuźniak
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 4957), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26164957 - link to the publication
  3. Conjugation of Diclofenac with Novel Oleanolic Acid Derivatives Modulate Nrf2 and NF-κB Activity in Hepatic Cancer Cells and Normal Hepatocytes Leading to Enhancement of Its Therapeutic and Chemopreventive Potential
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar, Małgorzata Kucińska, Robert Kleszcz, Jacek Kujawski, Hanna Piotrowska-Kempisty, Adam Plewiński, Marek Murias, Wanda Baer-Dubowska
    Academic press:
    Pharmaceuticals (rok: 2021, tom: 14, strony: 688), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph14070688 - link to the publication
  4. Indomethacin and Diclofenac Hybrids with Oleanolic Acid Oximes Modulate Key Signaling Pathways in Pancreatic Cancer Cells
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Robert Kleszcz, Wanda Baer-Dubowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 1230), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031230 - link to the publication
  5. Oleanolic acid oxime derivatives and their conjugates with aspirin modulate the NF-κBmediated transcription in HepG2 hepatoma cells
    Authors:
    Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar, Jarosław Paluszczak, Hanna Szaefer, Maria Narożna, Lucjusz Zaprutko, Wanda Baer-Dubowska
    Academic press:
    BIOORGANIC CHEMISTRY (rok: 2019, tom: 93, strony: 103326), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bioo - link to the publication
  6. Morpholide derivative of the novel oleanolic oxime and succinic acid conjugate diminish the expression and activity of NF-κB and STATs in human hepatocellular carcinoma cells
    Authors:
    Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar, Maria Narożna, Hanna Szaefer, Wanda Baer-Dubowska
    Academic press:
    Chemico-Biological Interactions (rok: 2019, tom: 311, strony: 108786), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.cbi.2019.108786 - link to the publication
  7. The Effect of Novel Oleanolic Acid Oximes Conjugated with Indomethacin on the Nrf2-ARE And NF-κB Signaling Pathways in Normal Hepatocytes and Human Hepatocellular Cancer Cells
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar, Robert Kleszcz, Wanda Baer-Dubowska
    Academic press:
    Pharmaceuticals (rok: 2021, tom: 14, strony: 32), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph14010032 - link to the publication
  1. Conjugation of indomethacin with novel oleanolic acid oximes increases its Nrf2 and NF-κB signaling pathways modulating effect in pancreatic cancer cells
    Authors:
    Wanda Baer-Dubowska, Maria Narożna, Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar
    Conference:
    AACR Annual Meeting 2021 (rok: 2021, ), Wydawca: AACR
    Data:
    konferencja April 10-15 and May 17-21 2021
    Status:
    Published
  2. NOVEL OLEANOLIC ACID OXIMES CONJUGATED WITH IBUPROFEN AND KETOPROFEN DOWNREGULATE THE NRF2- ARE SIGNALING PATHWAY IN HUMAN HEPATOCELLULAR CANCER CELLS IN CONTRAST TO NORMAL HEPATOCYTES
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar, Wanda Baer-Dubowska
    Conference:
    XXIV Gliwice Scientific Meeting (rok: 2020, ), Wydawca: B.m.2020
    Data:
    konferencja 20-21 November 2020
    Status:
    Published
  3. Synthesis and modulation of NF-kappaB pathway by new conjugates of oleanolic acid oximes and aspirin
    Authors:
    Bednarczyk-Cwynar B, Krajka-Kuźniak V., Paluszczak J., Szaefer H., Baer-Dubowska W.
    Conference:
    42nd FEBS Congress Jesrusalem, Israel (rok: 2017, ), Wydawca: FEBS
    Data:
    konferencja 40100
    Status:
    Published
  4. The effect of novel oleanolic acid derivatives on the expression and activity of transcription factors Nrf2 and Stat3 in HepG2 cells
    Authors:
    Narożna M, Krajka-Kuźniak V., Szaefer H., Baer-Dubowska W
    Conference:
    XXI Gliwice Scientific Meetings 2017 (rok: 2017, ), Wydawca: Instytut Onkologii im Marii Skłodowskiej-Curie i Gliwice, Śląski Uniwersytet Techniczny
    Data:
    konferencja 17-18 /11
    Status:
    Published
  5. Diclofenac hybrids with oleanolic acid oximes modulate key signaling pathways in pancreatic cancer cells
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Robert Kleszcz, Wanda Baer-Dubowska
    Conference:
    AACR Annual Meeting 2022 (rok: 2022, ), Wydawca: AACR
    Data:
    konferencja April 8-13, 2022
    Status:
    Accepted for publication
  6. Benzyl and morpholide derivatives of the novel oleanolic acid oximes conjugated with diclofenac downregulate the Nrf2-ARE signaling pathway in human hepatocellular cancer cells in comparison with normal hepatocytes
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar, Wanda Baer-Dubowska
    Conference:
    20th International Congress of Young Medical Scientists (rok: 2020, ), Wydawca: Uniwersytet Medyczny w Poznaniu
    Data:
    konferencja 28-30th May, 2020
    Status:
    Published
  7. Modulation of NF-kappaB signaling pathway by oleanolic acid derivatives and its conjugates with non-steroidal ant-inflammatory drugs in HepG2 hepatocellular cells line
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar, Robert Kleszcz, Wanda Baer-Dubowska
    Conference:
    BIO2018 Congress and 51st Meeting of the Polish Biochemical Society (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 18-21 września
    Status:
    Published
  8. Morpholide derivatives of the novel oleanolic oxime conjugated with diclofenac and indomethacin modulate the cell cycle, proliferation, apoptosis and inflammation markers in human hepatocellular cancer cells.
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Szaefer Hanna, Paluszczak Jarosław, Barbara Bednarczyk-Cwynar, Wanda Baer-Dubowska
    Conference:
    19th International Congress of Young Medical Scientists (rok: 2019, ), Wydawca: Uniwersytet Medyczny w Poznaniu
    Data:
    konferencja 43615
    Status:
    Published
  9. Novel synthetic derivatives of oleanolic acid conjugated with diclofenac modulate Nrf2-ARE signaling pathway in pancreatic cancer cells
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar, Robert Kleszcz, Wanda Baer-Dubowska
    Conference:
    The 44th FEBS Congress (rok: 2019, ), Wydawca: FEBS Open BIO
    Data:
    konferencja 43652
    Status:
    Published
  10. Modulation of the Nrf2 signaling pathwya by the new oleanolic acid derivatives in human hepatocellular carcinoma cells
    Authors:
    Krajka-Kuźniak V., Paluszczak J., Szaefer H., Dednarczyk-Cwynar B., Baer-Dubowska W.
    Conference:
    42nd FEBS Congress Jerusalem, Israel (rok: 2017, ), Wydawca: FEBS
    Data:
    konferencja 40100
    Status:
    Published
  11. Morpholide and methyl ester oleanolic acid oxime derivatives and their conjugates with aspirin modulate the cell cycle, proliferation and apoptosis in HepG2 hepatoma cells.
    Authors:
    Maria Narożna, Violetta Krajka-Kuźniak, Robert Kleszcz, Barbara Bednarczyk-Cwynar, Wanda Baer-Dubowska
    Conference:
    XXIIIrd Gliwice Scientific Meeting, Gliwice, November 22-23,2019 (rok: 2019, ), Wydawca: B.m. 2019
    Data:
    konferencja 43791
    Status:
    Published
  12. Oleanolic acid oxime derivatives modulate NF-κB signaling pathway leading to cell cycle arrest in pancreatic cancer cells
    Authors:
    Maria Narożna, Violetta Krajak-Kuźniak, Robert Kleszcz, Wanda Baer-Dubowska
    Conference:
    AACR Annual Meeting 2020, Philadelphia, PA, USA (rok: 2020, ), Wydawca: AACR
    Data:
    konferencja June 22-24, 2020
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy