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Assessment of the mechanism of R132H mutation of isocitrate dehydrogenase 1 gene (IDH1R132H) on differentiation and survivability of human induced neural stem cells

2016/21/N/NZ3/03271

Keywords:

isocitrate dehydrogenase 1 mutation differentiation mechanism neural stem cells glioma apoptosis

Descriptors:

  • NZ3_5: Molecular neurobiology
  • NZ3_6: Cell neurobiology
  • NZ3_8: Stem cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski, Oddział Nauk Biomedycznych

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Kamila Rosiak-Stec 

Number of co-investigators in the project: 2

Call: PRELUDIUM 11 - announced on 2016-03-15

Amount awarded: 149 580 PLN

Project start date (Y-m-d): 2017-05-15

Project end date (Y-m-d): 2020-10-14

Project duration:: 41 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (4)
  1. Generation of induced neural stem cells with inducible IDH1R132H for analysis of glioma development and drug testing
    Authors:
    Kamila Rosiak-Stec, Dagmara Grot, Piotr Rieske
    Academic press:
    PLOS One (rok: 2020, tom: 15(9), strony: e0239325 (1-17)), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0239325 - link to the publication
  1. Assessment of the effect of doxycycline-inducible IDH1R132H expression on induced neural stem cells differentiation towards neurons
    Authors:
    Dagmara Grot, Kamila Rosiak, Piotr Rieske
    Conference:
    XXIIIrd Gliwice Scientific Meetings (rok: 2019, ), Wydawca: Association for the Support of Cancer Research, Center of Oncology Maria Sklodowska- Curie Memorial Institute Branch in Gliwice, Silesian University of Technology, Gliwice
    Data:
    konferencja 22 - 23 listopada
    Status:
    Published
    DOI:
    link to the publication
  2. Induced neural stem cell based models for assessment of IDH1R132H mutation effects
    Authors:
    Dagmara Grot, Kamila Rosiak, Piotr Rieske
    Conference:
    XXIst Gliwice Scientific Meetings (rok: 2017, ), Wydawca: Association for the Support of Cancer Research, Center of Oncology Maria Sklodowska- Curie Memorial Institute Branch in Gliwice, Silesian University of Technology, Gliwice
    Data:
    konferencja 17-18 litopada
    Status:
    Published
    DOI:
    link to the publication
  3. Neuralne komórki macierzyste z indukowaną ekspresją IDH1R132H jako model do badań nad komórkowym pochodzeniem glejaków.
    Authors:
    Dagmara Grot, Kamila Rosiak-Stec, Piotr Rieske
    Conference:
    I Interdyscyplinarna Konferencja Doktorantów Uniwersytetu Medycznego w Łodzi (rok: 2020, ), Wydawca: Uniwersytet Medyczny w Łodzi, ISBN 978-83-953697-7-3
    Data:
    konferencja 7 listopada
    Status:
    Published
  4. Induced neural stem cells with doxycycline-inducible expression of IDH1R132H as a new tool for the study of mutant protein function.
    Authors:
    Dagmara Grot, Kamila Rosiak, Joanna Pęciak, Aleksandra Federkiewicz, Piotr Rieske
    Conference:
    XXIInd Gliwice Scientific Meetings (rok: 2018, ), Wydawca: Association for the Support of Cancer Research, Center of Oncology Maria Sklodowska- Curie Memorial Institute Branch in Gliwice, Silesian University of Technology, Gliwice
    Data:
    konferencja 16 - 17 listopada
    Status:
    Published
    DOI:
    link to the publication

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