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Modified borondipyrromethane derivatives (BODIPY) with selective photodynamic activity against cancer and bacterial cells

2016/21/D/NZ7/01540

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia
  • NZ6_4: Bakteriologia
  • NZ7_16: Inne zagadnienia pokrewne

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Jarosław Piskorz

Number of co-investigators in the project: 6

Call

SONATA 11 – announced on 2016-03-15

Amount awarded
862 450 PLN
Project start date
2017-02-06
Project end date
2022-02-05
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zestaw do chromatografii Flash z detektorem mas (np. CombiFlash RF+ PurIon, PuriFlash TM215 MS). Cost: 490 000 PLN

Information in the final report

Publication in academic press/journals (5)

  1. Serendipitous synthesis of unsymmetrical porphyrazine: Incomplete transesterification during macrocyclization

    Authors:
    Weronika Porolnik, Monika Kasprzycka, Anna Teubert, Jaroslaw Piskorz
    Academic press:
    Inorganic Chemistry Communications (year: 2021, volume: 133, pages: 108953 (1-5)), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.inoche.2021.108953 – link to the publication

  2. Photochemical Properties and Stability of BODIPY Dyes

    Authors:
    Patryk Rybczynski, Aleksander Smolarkiewicz-Wyczachowski, Jaroslaw Piskorz, Szymon Bocian, Marta Ziegler-Borowska, Dariusz Kedziera, Anna Kaczmarek-Kedziera
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 6735 (1-22)), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22136735 – link to the publication

  3. Boron-dipyrromethene derivatives bearing N-alkyl phthalimide and amine substituents of potential application in the photoinactivation of bacteria

    Authors:
    Jaroslaw Piskorz, Jolanta Dlugaszewska, Weronika Porolnik, Anna Teubert, Jadwiga Mielcarek
    Academic press:
    Dyes and Pigments (year: 2020, volume: 178, pages: 108322 (1-9)), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2020.108322 – link to the publication

  4. Tuning photodynamic properties of BODIPY dyes, porphyrins' little sisters

    Authors:
    Wojciech Krzemień, Monika Rohlickova, Miloslav Machacek, Veronika Novakova, Jarosław Piskorz, Petr Zimcik
    Academic press:
    Molecules (year: 2021, volume: 26, pages: 4194 (1-18)), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26144194 – link to the publication

  5. BODIPY-Based Photosensitizers as Potential Anticancer and Antibacterial Agents: Role of the Positive Charge and the Heavy Atom Effect

    Authors:
    Jaroslaw Piskorz, Weronika Porolnik, Malgorzata Kucinska, Jolanta Dlugaszewska, Marek Murias, Jadwiga Mielcarek
    Academic press:
    ChemMedChem (year: 2021, volume: 16, pages: 399-411), Publisher: Chemistry Europe
    Status:
    Published
    DOI:
    10.1002/cmdc.202000529 – link to the publication

Articles in post-conference publications (11)

  1. Novel dipyrrole and tetrapyrrole-based photosensitizers with various biphenylmethyl substituents of potential application in PDT

    Authors:
    Porolnik W., Podciechowska K., Kasprzycka M., Foltynowicz M., Górzna N., Maćkowiak A., Karpińska N., Teubert A., Piskorz J.
    Conference:
    XXXII Annual Conference of the Italian Society of Photobiology SIFB 2021 (year: 2021, pages: 34), Publisher: Società Italiana di Fotobiologia
    Date:
    conference 44370
    Status:
    Published

  2. In vitro photodynamic antimicrobial activity of novel boron-dipyrromethene derivatives substituted with various alkylamine substituents

    Authors:
    Piskorz J., Porolnik W., Dlugaszewska J., Mielcarek J.
    Conference:
    18th Blue Danube Symposium on Heterocyclic Chemistry (year: 2019, pages: 53), Publisher: University of Ljubljana Faculty of Chemistry and Chemical Technology
    Date:
    conference 43726
    Status:
    Published

  3. Synthesis, photochemical and antimicrobial studies of novel BODIPY-based photosensitizers with various alkylamine substituents

    Authors:
    Piskorz J., Porolnik W., Dlugaszewska J., Teubert A., Mielcarek J.
    Conference:
    11th International Conference on Porphyrins and Phthalocyanines ICPP-11 (year: 2021, pages: 440), Publisher: Society of Porphyrins & Phthalocyanines
    Date:
    conference 44344
    Status:
    Published

  4. Novel BODIPYs with strong heavy atom effect as dual photosensitizers for antimicrobial and anticancer PDT

    Authors:
    Porolnik W., Kucinska M., Dlugaszewska J., Murias M., Mielcarek J., Piskorz J.
    Conference:
    1st HighLIGHTing Science Meeting & PANIC 2021 (year: 2021, pages: 89), Publisher: Oficyna Wydawnicza Politechniki Wrocławskiej
    Date:
    conference 44342
    Status:
    Published

  5. Novel BODIPY derivatives possessing aliphatic tertiary and quaternary amine groups as efficient anticancer and antibacterial photosensitizers

    Authors:
    Porolnik W., Kucinska M., Dlugaszewska J., Murias M., Mielcarek J., Piskorz J.
    Conference:
    XXXII Annual Conference of the Italian Society of Photobiology SIFB 2021 (year: 2021, pages: 26), Publisher: Società Italiana di Fotobiologia
    Date:
    conference 44370
    Status:
    Published

  6. Synthesis of phthalimide sulfanyl porphyrazines and their optical properties

    Authors:
    Michal Falkowski a , Lukasz PopeFalkowski M., Popenda L., Piskorz J., Wieczorek E., Jurga S., Marszall M.P., Mieszkowski D., Mielcarek J., Goslinski T.
    Conference:
    NanoTech Poland 2018 & 1st Symposium on Polydopamine (year: 2018, pages: 130), Publisher: NanoTech Poland 2018 & 1st Symposium on Polydopamine
    Date:
    conference 06-09.06.2018
    Status:
    Published

  7. Novel BODIPYs with dimethylamine substituents and their cationic and iodinated derivatives for anticancer and antibacterial photodynamic therapy

    Authors:
    Porolnik W., Kucinska M., Dlugaszewska J., Murias M., Mielcarek J., Piskorz J.
    Conference:
    6th International Electronic Conference on Medicinal Chemistry (year: 2020, pages: https://sciforum.net/paper/view/conference/7457), Publisher: sciforum
    Date:
    conference 01.11-30.11
    Status:
    Published

  8. Development of the novel boron-dipyrromethene derivatives of potential application in the photodynamic therapy

    Authors:
    Porolnik W., Podciechowska K., Wieczorek E., Krzemień W., Teubert A., Mielcarek J., Piskorz J.
    Conference:
    Chemistry Beyond Nature (year: 2018, pages: 177), Publisher: Cursiva
    Date:
    conference 21-22.06.2018
    Status:
    Published

  9. Boron-dipyrromethene (BODIPY) derivatives bearing N-alkyl phthalimide and amine substituents of potential application in the photoinactivation of bacteria

    Authors:
    Piskorz J., Dlugaszewska J., Gdaniec Z., Mielcarek J.
    Conference:
    Annual Congress of the Italian Society of Photobiology – SIFB2019 (year: 2019, pages: 46-47), Publisher: Società Italiana di Fotobiologia
    Date:
    conference 43635
    Status:
    Published

  10. In vitro photodynamic antimicrobial activity of novel boron-dipyrromethene derivatives with aliphatic tertiary and quaternary amino substituents

    Authors:
    Porolnik W., Długaszewska J., Mielcarek J., Piskorz J.
    Conference:
    Annual Congress of the Italian Society of Photobiology – SIFB2019 (year: 2019, pages: 46-47), Publisher: Società Italiana di Fotobiologia
    Date:
    conference 43635
    Status:
    Published

  11. Novel boron-dipyrromethene derivatives as potential photosensitizers for the photodynamic therapy

    Authors:
    Porolnik W., Podciechowska K., Teubert A., Mielcarek J., Piskorz. J
    Conference:
    IX Konwersatorium Chemii Medycznej (year: 2018, pages: P100), Publisher: IX Konwersatorium Chemii Medycznej
    Date:
    conference 13-15.09.2018
    Status:
    Published

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