Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Immunoliposomal form of simvastatin - an attempt to use in the treatment of EGFR-dependent tumors.

2016/21/B/NZ7/01070

Keywords:

statins EGFR-dependent tumors immunoliposomes

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ5_7: Human disease treatment

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Aleksander Sikorski 

Number of co-investigators in the project: 3

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 387 400 PLN

Project start date (Y-m-d): 2017-01-18

Project end date (Y-m-d): 2019-04-17

Project duration:: 27 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  1. Attempts to use statins in cancertherapy: An update
    Authors:
    Lucyna Matusewicz, Aleksander Czogalla and Aleksander F Sikorski
    Academic press:
    Tumor Biology (rok: 2020, tom: 42(7), strony: 7), Wydawca: SAGE
    Status:
    Published
    DOI:
    10.1177/1010428320941760.2020 - link to the publication
  2. Kierowany za pomocą przeciwciał, liposomowy preparat statyny oraz jego zastosowanie
    Authors:
    Lucyna Matusewicz, Aleksander F. Sikorski
    Academic press:
    Biuletyn Urzędu Patentowego (rok: 2019, tom: 23/2019, strony: 6, 425432 udzielony patent Pat.236106), Wydawca: URZĄD PATENTOWY RZECZYPOSPOLITEJ POLSKIEJ
    Status:
    Published
    DOI:
    brak - link to the publication
  3. EGFR-targeted immunoliposomes as a selective delivery system of simvastatin, with potential use in treatment of triple-negative breast cancers
    Authors:
    Lucyna Matusewicz1, Beata Filip-Psurska2, Mateusz Psurski2, Sabina Tabaczar1, Joanna Podkalicka1, Joanna Wietrzyk2, Piotr Ziółkowski3, Aleksander Czogalla1, Aleksander F. Sikorski1
    Academic press:
    International Journal of Parmaceutics (rok: 2019, tom: 569,, strony: 118605), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2019.118605 - link to the publication
  4. Immunoliposomes with Simvastatin as a Potential Therapeutic in Treatment of Breast Cancer Cells Overexpressing HER2-An In Vitro Study.
    Authors:
    Matusewicz L, Podkalicka J, Sikorski AF.
    Academic press:
    Cancers (Basel). (rok: 2018, tom: 10(11)., strony: pii: E418.), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers10110418. - link to the publication
  1. Liposomes targeted with Therapeutic Antibodies a Lego-block Versatile Tool for Anticancer Therapy.
    Authors:
    Sikorski A.F.
    Conference:
    PCS 4th Annual Global Cancer Conference-2017 and PCS 4th World Congerss of Cardiothoratic-Renal Diseases-2017, Lisbon, (rok: 2017, ), Wydawca: PCS
    Data:
    konferencja 4-5.11
    Status:
    Published
  2. Simvastatin immunoliposomes as potential therapeutic treatment of EGF receptor family-dependent breast tumors.
    Authors:
    Matusewicz L., Sikorski A.F.
    Conference:
    Liposome Advances, Progress in Drug and Vaccine Delivery. ILS and Liposome research Days Combined Conference (rok: 2017, ), Wydawca: ILS
    Data:
    konferencja 16-17. 09
    Status:
    Published

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