Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Immunomodulatory activities of cathelicidin LL-37 and its amphipathic analogs in urinary tract infections

2016/21/N/NZ6/02213

Keywords:

cathelicidin LL-37 urinary tract analogues AMPs

Descriptors:

  • NZ6_4: Bacteriology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Lekarski z Oddziałem Stomatologii i Oddziałem Nauczania w Języku Angielskim

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Urszula Wnorowska 

Number of co-investigators in the project: 3

Call: PRELUDIUM 11 - announced on 2016-03-15

Amount awarded: 149 160 PLN

Project start date (Y-m-d): 2017-01-13

Project end date (Y-m-d): 2021-07-12

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (4)
  1. Nanoantibiotics containing membrane-active human cathelicidin LL-37 or synthetic ceragenins attached to the surface of magnetic nanoparticles as novel and innovative therapeutic tools: current status and potential future applications
    Authors:
    Wnorowska Urszula, Fiedoruk Krzysztof, Piktel Ewelina, Prasad Suhanya Veronica, Sulik Magdalena, Janion Marianna, Daniluk Tamara, Savage Paul, Bucki Robert
    Academic press:
    Journal of Nanobiotechnology (rok: 2020, tom: 18, strony: 18), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12951-019-0566-z - link to the publication
  2. Use of ceragenins as a potential treatment for urinary tract infections
    Authors:
    Wnorowska Urszula, Piktel S.D. Ewelina, Durnaś Bonita, Fiedoruk Krzysztof, Savage Paul B., Bucki Robert
    Academic press:
    BMC Infectious Diseases (rok: 2019, tom: 19,1, strony: Article number: 369, 13pp), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12879-019-3994-3 - link to the publication
  1. Activity of ceragenins against Escherichia coli strains involved in the urinary tract infections
    Authors:
    Gołaszewska Agnieszka, Wnorowska Urszula, Cieśluk Mateusz, Fiedoruk Krzysztof, Prasad Suhanya Veronica, Durnaś Bonita
    Conference:
    14TH Bialystok International Medical Congress for Young Scientists (rok: 2019, ), Wydawca: Uniwersytet Medyczny w Białymstoku
    Data:
    konferencja 17.05-18.05.2019
    Status:
    Published
  2. A place for ceragenis and LL-37 peptide in treatment of urinary tract infections
    Authors:
    Urszula Wnorowska, Ewelina Piktel, Bonita Durnaś, P. Savage, Mateusz Cieśluk, Piotr Deptuła, Robert Bucki.
    Conference:
    3rd Gulf Congress of Clinical Microbiology & Infectious Diseases GCCMID (rok: 2018, ), Wydawca: Emirates Infectious Diseases Society
    Data:
    konferencja 7-10 Listopad
    Status:
    Published
  3. Aktywność przeciwbakteryjna peptydu LL - 37 oraz ceragenin w modelu in vitro zakażenia układu moczowego
    Authors:
    Urszula Wnorowska, Ewelina Piktel, Paul B. Savage, Robert Bucki
    Conference:
    60 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (rok: 2017, ), Wydawca: Polskie Towarzystwo Chemiczne
    Data:
    konferencja 17-21 wrzesień
    Status:
    Published
  4. Synergistyczne oddziaływanie peptydu LL-37 i cerageniny CSA-131 w stosunku do klinicznych szczepów E. coli izolowanych od pacjentów z zakażeniem układu moczowego
    Authors:
    Urszula Wnorowska, Ewelina Piktel, Grzegorz Michalak, Paul B. Savage, Robert Bucki
    Conference:
    V Konferencja Związki Biologicznie Czynne: aktywność, struktura, synteza (rok: 2017, ), Wydawca: Uniwersytet w Białymstoku
    Data:
    konferencja 09-11 czerwca
    Status:
    Published