Projects funded by the NCN

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Mechanism of interaction between carbon nanoparticles of diamond, graphene oxide and graphite and cytochrome P450 enzymes - studies on in vitro, in vivo and in silico models

2016/21/N/NZ7/03344

Keywords:

carbon nanoparticles diamond graphene oxide graphite cytochrome P450

Descriptors:

  • NZ7_16: Other related subjects
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_12: Prevention of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Wydział Nauk o Zwierzętach

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Barbara Strojny 

Number of co-investigators in the project: 3

Call: PRELUDIUM 11 - announced on 2016-03-15

Amount awarded: 148 800 PLN

Project start date (Y-m-d): 2017-04-13

Project end date (Y-m-d): 2020-04-12

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Nanostructures of diamond, graphene oxide and graphite inhibit CYP1A2, CYP2D6 and CYP3A4 enzymes and downregulate their genes in liver cells
    Authors:
    Barbara Strojny, Ewa Sawosz, Marta Grodzik, Sławomir Jaworski, Jarosław Szczepaniak, Malwina Sosnowska, Mateusz Wierzbicki, Marta Kutwin, Sylwia Orlińska, André Chwalibog
    Academic press:
    International Journal of Nanomedicine (rok: 2018, tom: 13, strony: 8561–8575), Wydawca: Dove Press
    Status:
    Published
    DOI:
    10.2147/IJN.S188997 - link to the publication
  2. Effect of Graphene Family Materials on Multiple Myeloma and Non-Hodgkin's Lymphoma Cell Lines
    Authors:
    Barbara Strojny, Sławomir Jaworski, Irena Misiewicz-Krzemińska, Isabel Isidro, Elizabeta A. Rojas, Norma C. Gutiérrez, Marta Grodzik, André Chwalibog, Ewa Sawosz
    Academic press:
    Materials (rok: 2020, tom: 13, strony: 3420), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma13153420 - link to the publication
  3. Influence of Selected Carbon Nanostructures on the CYP2C9 Enzyme of the P450 Cytochrome
    Authors:
    Justyna Sekretarska, Jarosław Szczepaniak, Malwina Sosnowska, Marta Grodzik, Marta Kutwin, Mateusz Wierzbicki, Sławomir Jaworski, Jasmina Bałaban, Karolina Daniluk, Ewa Sawosz, André Chwalibog, Barbara Strojny
    Academic press:
    Materials (rok: 2019, tom: 12, strony: 45305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma12244149 - link to the publication

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