Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Importance of cyclin F-RRM2 axis in drug-resistance of melanoma cells with different degree of aggressiveness - in vitro studies

2016/21/B/NZ7/01121

Keywords:

melanoma cells cisplatin temozolomide UV radiation drug-resistance cyclin F RRM2

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ3_1: Cell biology
  • NZ5_7: Human disease treatment

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Wydział Lekarski

woj. kujawsko-pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Alina Grzanka 

Number of co-investigators in the project: 6

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 364 400 PLN

Project start date (Y-m-d): 2017-03-02

Project end date (Y-m-d): 2022-03-01

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Cytometr przepływowy z podajnikiem na płytki 96-dołkowe (310 000 PLN)
  2. Emiter promieniowania UV (20 000 PLN)
  3. Jednostka Y Nucleofektora 4D (75 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Cyclin F Downregulation Affects Epithelial-Mesenchymal Transition Increasing Proliferation and Migration of the A-375 Melanoma Cell Line
    Authors:
    Adrian Krajewski, Maciej Gagat, Klaudia Mikołajczyk, Magdalena Izdebska, Agnieszka Żuryń, Alina Grzanka
    Academic press:
    Cancer Management and Research (rok: 2020, tom: 12, strony: 13085-13097), Wydawca: DovePress
    Status:
    Published
    DOI:
    10.2147/CMAR.S279169 - link to the publication
  2. Cyclin F is involved in response to cisplatin treatment in melanoma cell lines
    Authors:
    Adrian Krajewski, Maciej Gagat, Agnieszka Żuryń, Marta Hałas-Wiśniewska, Dariusz Grzanka, Alina Grzanka
    Academic press:
    Oncology Reports (rok: 2020, tom: 43, strony: 765-772), Wydawca: Spandidos Publications UK LTD
    Status:
    Published
    DOI:
    10.3892/or.2020.7465 - link to the publication
  3. Potential role of cyclin F mRNA expression in the survival of skin melanoma patients: Comprehensive analysis of the pathways altered due to cyclin F upregulation
    Authors:
    Gagat Maciej, Krajewski Adrian, Grzanka Dariusz, Grzanka Alina
    Academic press:
    Oncology Reports (rok: 2018, tom: 40, strony: 123-144), Wydawca: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/or.2018.6435. - link to the publication

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