Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Elaboration and characteristics of biocomposites with anti-virulent and anti-bacterial properties against Pseudomonas aeruginosa

2016/21/B/NZ6/01157

Keywords:

Pseudomonas aeruginosa biofilm phage virulence biocomposite

Descriptors:

  • NZ6_4:
  • NZ6_5:
  • ST5_11:

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Zuzanna Drulis-Kawa 

Number of co-investigators in the project: 11

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 480 600 PLN

Project start date (Y-m-d): 2017-05-19

Project end date (Y-m-d): 2022-05-18

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. czytnik mikropłytek VARIOSKAN LUX THERMO (140 000 PLN)
  2. zestaw laserów i MCOMB.
  3. zestaw dwóch kuwet kwarcowych pozwalających na ocenę dyfuzji w insertach z zastosowaniem techniki interferometrii laserowej z układem stabilizującym temperaturę (50 000 PLN)
  4. kamera ORCA-Flasch CMOS do mikroskopu konfokalnego (150 000 PLN)
  5. System do Real-Time qPCR typu CFX96 Touch System (150 000 PLN)

Information in the final report

  • Publication in academic press/journals (19)
  • Articles in post-conference publications (2)
  1. Applications of bacteriophages versus phage enzymes to combat and cure bacterial infections: an ambitious and also a realistic application?
    Authors:
    Barbara Maciejewska, Tomasz Olszak, Zuzanna Drulis-Kawa
    Academic press:
    Applied Microbiology and Biotechnology (rok: 2018, tom: 102, strony: 2563–2581), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00253-018-8811-1 - link to the publication
  2. Culture media composition influences the antibacterial effect of silver, cupric, and zinc ions against Pseudomonas aeruginosa
    Authors:
    Justyna Rewak-Soroczynska, Agata Dorotkiewicz-Jach *, Zuzanna Drulis-Kawa, Rafal J. Wiglusz
    Academic press:
    Biomolecules (rok: 2022, tom: 12(7), strony: 963), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom12070963 - link to the publication
  3. Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes
    Authors:
    Katarzyna Gałczynska, Zuzanna Drulis-Kawa and Michał Arabski
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: Jul 31;25(15):3492), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25153492. - link to the publication
  4. The Influence of Ozonated Olive Oil-Loaded and Copper-Doped Nanohydroxyapatites on Planktonic Forms of Microorganisms
    Authors:
    Wojciech Zakrzewski, Maciej Dobrzynski, Joanna Nowicka, Magdalena Pajaczkowska, Maria Szymonowicz, Sara Targonska, Paulina Sobierajska, Katarzyna Wiglusz, Wojciech Dobrzynski, Adam Lubojanski, Sebastian Fedorowicz, Zbigniew Rybak and Rafal J. Wiglusz
    Academic press:
    Nanomaterials (rok: 2020, tom: 10,, strony: 1997), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nano10101997 - link to the publication
  5. Targeting biofilms using phages and their enzymes
    Authors:
    Joana Azeredo, Pilar Garcıa, Zuzanna Drulis-Kawa
    Academic press:
    Current Opinion in Biotechnology (rok: 2021, tom: 68, strony: 251–261), Wydawca: Elsevier Ltd.
    Status:
    Published
    DOI:
    10.1016/j.c - link to the publication
  6. Modelling experimentally measured of ciprofloxacin antibiotic diffusion in Pseudomonas aeruginosa biofilm formed in artificial sputum medium
    Authors:
    Tadeusz Kosztołowicz, Ralf Metzler, Sławomir Wa̡sik, Michał Arabski
    Academic press:
    PlosONE (rok: 2020, tom: 15, strony: Dec 3;15(12):e0243003.), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0243003 - link to the publication
  7. Selective cytotoxicity and antifungal properties of copper(II) and cobalt(II) complexes with imidazole-4-acetate anion or 1-allylimidazole
    Authors:
    Katarzyna Gałczyńska, Karol Ciepluch, Łukasz Madej, Krystyna Kurdziel, Barbara Maciejewska, Zuzanna Drulis-Kawa, Aneta Węgierek-Ciuk Anna Lankoff, Michał Arabski
    Academic press:
    Scientific Reports (rok: 2019, tom: Jul 5;9(1), strony: Jul 5;9(1):9777.), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-019-46224-6. - link to the publication
  8. Multifunctionality of Nanosized Calcium Apatite Dual-Doped with Li+/Eu3+ Ions Related to Cell Culture Studies and Cytotoxicity Evaluation In Vitro
    Authors:
    Paulina Sobierajska, Blazej Pozniak, Marta Tikhomirov, Julia Miller, Lucyna Mrowczynska, Agata Piecuch, Justyna Rewak-Soroczynska, Agata Dorotkiewicz-Jach, Zuzanna Drulis-Kawa, Rafal J. Wiglusz
    Academic press:
    Biomolecules (rok: 2021, tom: 11, strony: 1388), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom11091388 - link to the publication
  9. Preparation of a New Biocomposite Designed for Cartilage Grafting with Antibiofilm Activity
    Authors:
    Sara Targonska, Justyna Rewak-Soroczynska, Agata Piecuch, Emil Paluch, Damian Szymanski, and Rafal J. Wiglusz
    Academic press:
    ACS Omega (rok: 2020, tom: 38, strony: 5, 38, 24546–24557), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acsomega.0c03044 - link to the publication
  10. Outer Membrane Vesicles (OMVs) of Pseudomonas aeruginosa Provide Passive Resistance but Not Sensitization to LPS-Specific Phages
    Authors:
    Daria Augustyniak, Tomasz Olszak, Zuzanna Drulis-Kawa
    Academic press:
    Viruses (rok: 2022, tom: 14, strony: 121), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v14010121 - link to the publication
  11. Quenching of the Eu3+ Luminescence by Cu2+ Ions in the Nanosized Hydroxyapatite Designed for Future Bio-Detection
    Authors:
    Katarzyna Szyszka, Sara Targonska, Agnieszka Lewinska, Adam Watras, Rafal J. Wiglusz
    Academic press:
    Nanomaterials (rok: 2021, tom: 11, strony: 464), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  12. The Application of Impedance Spectroscopy for Pseudomonas Biofilm Monitoring during Phage Infection
    Authors:
    Grzegorz Guła, Paulina Szymanowska, Tomasz Piasecki , Sylwia Góras, Teodor Gotszalk and Zuzanna Drulis-Kawa
    Academic press:
    Viruses (rok: 2020, tom: 12, strony: Apr 7;12(4):407), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v12040407 - link to the publication
  13. Complex Signaling Networks Controlling Dynamic Molecular Changes in Pseudomonas aeruginosa Biofilm
    Authors:
    Grzegorz Guła, Agata Dorotkiewicz-Jach, Kamila Korzekwa, Miguel A. Valvano, Zuzanna Drulis-Kawa
    Academic press:
    Current Medicinal Chemistry (rok: 2019, tom: 26, strony: 1979-1993), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    10.2174/0929867325666180912110151 - link to the publication
  14. Editorial Special Issue: Bacteriophages and Biofilms"
    Authors:
    Zuzanna Drulis-Kawa, Barbara Maciejewska
    Academic press:
    Viruses (rok: 2021, tom: 13, strony: 257), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v13020257 - link to the publication
  15. A Study of the Impact of Graphene Oxide on Viral Infection Related to A549 and TC28a2 Human Cell Lines
    Authors:
    Piotr Kuropka, Maciej Dobrzynski, Barbara Bazanow, Dominika Stygar, Tomasz Gebarowski, Anna Leskow, Malgorzata Tarnowska, Katarzyna Szyszka, Malgorzata Malecka, Nicole Nowak, Wieslaw Strek, Rafal J.Wiglusz
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 7788), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  16. Culture media composition influences the antibacterial effect of silver, cupric, and zinc ions against Pseudomonas aeruginosa
    Authors:
    Justyna Rewak-Soroczynska, Agata Dorotkiewicz-Jach *, Zuzanna Drulis-Kawa, Rafal J. Wiglusz
    Academic press:
    Biomolecules (rok: 2022, tom: 12(7), strony: 963), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom12070963 - link to the publication
  17. The In Vitro Anti-Pseudomonal Activity of Cu2+, Strawberry Furanone, Gentamicin, and Lytic Phages Alone and in Combination: Pros and Cons
    Authors:
    Agata Dorotkiewicz-Jach, Pawel Markwitz, Zuzanna Drulis-Kawa
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 11562), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22189830 - link to the publication
  18. New Approach to Antifungal Activity of Fluconazole Incorporated into the Porous 6-Anhydro--L-Galacto--D -Galactan Structures Modified with Nanohydroxyapatite for Chronic-Wound Treatments—In Vitro Evaluation
    Authors:
    Justyna Rewak-Soroczynska, Paulina Sobierajska, Sara Targonska, Agata Piecuch, Lukasz Grosman, Jaroslaw Rachuna, SlawomirWasik, Michal Arabski, Rafal Ogorek and Rafal J. Wiglusz
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 3112), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22063112 - link to the publication
  19. Editorial Special Issue: Bacteriophages and Biofilms"
    Authors:
    Zuzanna Drulis-Kawa, Barbara Maciejewska
    Academic press:
    Viruses (rok: 2021, tom: 13, strony: 257), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v13020257 - link to the publication
  1. Przegląd badań aktywności biologicznych jonów lantanowców
    Authors:
    Justyna Rewak-Soroczyńska, Agata Dorotkiewicz-Jach, Rafał J. Wiglusz
    Conference:
    XIV Interdyscyplinarna Konferencja Naukowa TYGIEL 2022 "Interdyscyplinarność kluczem do rozwoju" konferencja Lublin/online (rok: 2022, ), Wydawca: Wydawnictwo Naukowe TYGIEL, ul. Głowackiego 35/348, 20-060 Lublin
    Data:
    konferencja 24-27.03.2022
    Status:
    Published
  2. Przegląd badań aktywności biologicznych jonów lantanowców
    Authors:
    Justyna Rewak-Soroczyńska, Agata Dorotkiewicz-Jach, Rafał J. Wiglusz
    Conference:
    XIV Interdyscyplinarna Konferencja Naukowa TYGIEL 2022 "Interdyscyplinarność kluczem do rozwoju" konferencja Lublin/online (rok: 2022, ), Wydawca: Wydawnictwo Naukowe TYGIEL, ul. Głowackiego 35/348, 20-060 Lublin
    Data:
    konferencja 24-27.03.2022
    Status:
    Published

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