Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Epitope mapping of Clostridium difficile surface proteins with characteristics of protective properties of epitope conjugated with carrier protein in combination with novel nanoadjuvant.

2016/21/B/NZ6/02286

Keywords:

antigen vaccine umbilical cord blood Clostridium difficile infection

Descriptors:

  • NZ6_4: Bacteriology
  • NZ6_8: Other related subjects
  • NZ7_12: Prevention of human diseases

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Andrzej Gamian 

Number of co-investigators in the project: 7

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 766 580 PLN

Project start date (Y-m-d): 2017-02-17

Project end date (Y-m-d): 2021-02-16

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Mikser laboratoryjny (15 000 PLN)
  2. Odwrócony mikroskop biologiczny z komputerem i oprogramowaniem (80 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. The Bioinformatic and In Vitro Studies of Clostridioides Difficile Aminopeptidase M24 Revealed the Immunoreactive KKGIK Peptide
    Authors:
    Pacyga K., Razim A., Martirosian G., Aptekorz M., Szuba A., Gamian A., Myc A., Górska S.
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 1146), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9051146 - link to the publication
  2. Epitopes identified in GAPDH from Clostridium difficile recognized as common antigens with potential autoimmunizing properties
    Authors:
    Agnieszka Razim, Katarzyna Pacyga, Małgorzata Aptekorz, Gayane Martirosian, Andrzej Szuba, Edyta Pawlak-Adamska, Monika Brzychczy-Włoch, Andrzej Myc, Andrzej Gamian, Sabina Górska
    Academic press:
    Scientific Reports (rok: 2018, tom: 8, strony: 13946), Wydawca: Springer Nature Publishing AG
    Status:
    Published
    DOI:
    10.1038/s41598-018-32193-9 - link to the publication
  3. Flagellar proteins as candidate vaccine antigens: identification of Clostridioides difficile FliC and FliD linear epitopes using patients' serum antibodies
    Authors:
    Razim A., Pacyga K., Naporowski P., Martynowski D., Szuba A., Gamian A., Górska S.
    Academic press:
    Scientific Reports (rok: 2021, tom: 11(1), strony: 45304), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-89488-7 - link to the publication
  4. Mapping Epitopes of a Novel Peptidoglycan Cross-Linking Enzyme Cwp22 Recognized by Human Sera Obtained from Patients with Clostridioides difficile Infection and Cord Blood
    Authors:
    Razim Agnieszka, Pacyga Katarzyna, Martirosian Gajene, Szuba Andrzej, Gamian Andrzej, Myc Andrzej, Górska Sabina
    Academic press:
    Microorganisms (rok: 2019, tom: 7, strony: 565), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/microorganisms7110565 - link to the publication

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