Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Determination of function WWOX gene in AP-2 signaling pathway in bladder cancer.

2016/21/B/NZ2/01823

Keywords:

WWOX gene bladder cancer AP-2 transcription factor

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ2_7: Bioinformatics
  • NZ2_1: Molecular genetics

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Elżbieta Płuciennik 

Number of co-investigators in the project: 5

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 793 500 PLN

Project start date (Y-m-d): 2017-02-16

Project end date (Y-m-d): 2022-02-15

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Bioanalyzer (150 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (5)
  1. Fragile Gene WWOX Guides TFAP2A/ TFAP2C-Dependent Actions Against Tumor Progression in Grade II Bladder Cancer
    Authors:
    Damian Kołat , Żaneta Kałuzińska , Andrzej K Bednarek , Elżbieta Płuciennik
    Academic press:
    Frontiers in Oncology (rok: 2021, tom: 11, strony: 735435), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fonc.2021.735435 - link to the publication
  2. In vitro and in silico assessment of the effect of WWOX expression on invasiveness pathways associated with AP-2 transcription factors in bladder cancer
    Authors:
    Żaneta Kałuzińska , Damian Kołat , Katarzyna Kośla , Magdalena Orzechowska , Andrzej K Bednarek , Elżbieta Płuciennik
    Academic press:
    BMC Urology (rok: 2021, tom: 21, strony: 36), Wydawca: Part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12894-021-00806-7 - link to the publication
  3. The biological characteristics of transcription factors AP-2α and AP-2γ and their importance in various types of cancers
    Authors:
    Damian Kolat, Żaneta Kaluzińska, Andrzej K. Bednarek, Elżbieta Pluciennik
    Academic press:
    Bioscience Reports (rok: 2019, tom: 15 (39), strony: BSR20181928), Wydawca: Portland Press
    Status:
    Published
    DOI:
    10.1042/BSR20181928 - link to the publication
  4. Determination of WWOX Function in Modulating Cellular Pathways Activated by AP-2α and AP-2γ Transcription Factors in Bladder Cancer
    Authors:
    Damian Kołat , Żaneta Kałuzińska , Andrzej K Bednarek , Elżbieta Płuciennik
    Academic press:
    Cells (rok: 2022, tom: 19, strony: 1382), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11091382 - link to the publication
  5. WWOX Loses the Ability to Regulate Oncogenic AP-2γ and Synergizes with Tumor Suppressor AP-2α in High-Grade Bladder Cancer
    Authors:
    Damian Kołat, Żaneta Kałuzińska, Andrzej K Bednarek , Elżbieta Płuciennik
    Academic press:
    Cancers ( Basel) (rok: 2021, tom: 13, strony: 2957), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13122957 - link to the publication
  1. Interakcje WWOX i AP-2γ w raku pęcherza moczowego - analizy in vitro oraz in silico
    Authors:
    Damian Kołat, Żaneta Kałuzińska, Elżbieta Płuciennik
    Conference:
    I Interdyscyplinarnej Konferencji Doktorantów Uniwersytetu Medycznego w Łodz i"DocUMED" (rok: 2020, ), Wydawca: Uniwersytet Medyczny w Łodzi
    Data:
    konferencja 7 listopada
    Status:
    Published
  2. The regulation of AP2-α transcription factor via WWOX protein and its influence in bladder carcinogenesis
    Authors:
    Żaneta Kałuzińska, Damian Kołat, Magdalena Orzechowska, Elżbieta Płuciennik
    Conference:
    Symbioza , 8 Intercollegiate Biotechnology Symposium (rok: 2019, ), Wydawca: Wydział Biologii UW,
    Data:
    konferencja 17.05-19.05
    Status:
    Published
  3. WWOX may lose ability to regulate pro-tumoral AP-2γ but still possesses synergism with tumor suppressor AP-2α in high-grade bladder cancer.
    Authors:
    Kołat Damian, Kałuzińska Żaneta, Płuciennik Elżbieta
    Conference:
    XXIV Gliwice Scientific Meetings (rok: 2020, ), Wydawca: Association for the Support of Cancer Research Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch Silesian University of Technology
    Data:
    konferencja 20-21 listopada
    Status:
    Published
  4. WWOX–AP-2α interaction affects biology of bladder cancer and demonstrates usefulness in its clinical features' discrimination
    Authors:
    Damian Kołat, Żaneta Kałuzińska, Elżbieta Płuciennik
    Conference:
    GLOBAL CONGRESS ON BLADDR CANCER (rok: 2020, ), Wydawca: e-HIMS bvba
    Data:
    konferencja 10-15 pażdziernik
    Status:
    Published
  5. Determination of the WWOX gene function in AP-2gamma signaling pathway in metastatic bladder cancer
    Authors:
    E. Płuciennik, D. Kołat, Z. Kałuzinska, M. Orzechowska, K. Kosla, A. K. Bednarek
    Conference:
    FEBS (rok: 2019, ), Wydawca: 0.1002/2211-5463.12675
    Data:
    konferencja 6-11 lipiec
    Status:
    Published

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