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Determination of function WWOX gene in AP-2 signaling pathway in bladder cancer.

2016/21/B/NZ2/01823

Keywords

Descriptors

  • NZ2_2: Genomika, transkryptomika i epigenomika
  • NZ2_7: Bioinformatyka
  • NZ2_1: Genetyka molekularna

Panel

NZ2 – Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Elżbieta Janina Płuciennik

Number of co-investigators in the project: 5

Call

OPUS 11 – announced on 2016-03-15

Amount awarded
793 500 PLN
Project start date
2017-02-16
Project end date
2022-02-15
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Bioanalyzer. Cost: 150 000 PLN

Information in the final report

Publication in academic press/journals (5)

  1. WWOX Loses the Ability to Regulate Oncogenic AP-2γ and Synergizes with Tumor Suppressor AP-2α in High-Grade Bladder Cancer

    Authors:
    Damian Kołat, Żaneta Kałuzińska, Andrzej K Bednarek , Elżbieta Płuciennik
    Academic press:
    Cancers ( Basel) (year: 2021, volume: 13, pages: 2957), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13122957 – link to the publication

  2. Determination of WWOX Function in Modulating Cellular Pathways Activated by AP-2α and AP-2γ Transcription Factors in Bladder Cancer

    Authors:
    Damian Kołat , Żaneta Kałuzińska , Andrzej K Bednarek , Elżbieta Płuciennik
    Academic press:
    Cells (year: 2022, volume: 19, pages: 1382), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11091382 – link to the publication

  3. Fragile Gene WWOX Guides TFAP2A/ TFAP2C-Dependent Actions Against Tumor Progression in Grade II Bladder Cancer

    Authors:
    Damian Kołat , Żaneta Kałuzińska , Andrzej K Bednarek , Elżbieta Płuciennik
    Academic press:
    Frontiers in Oncology (year: 2021, volume: 11, pages: 735435), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fonc.2021.735435 – link to the publication

  4. The biological characteristics of transcription factors AP-2α and AP-2γ and their importance in various types of cancers

    Authors:
    Damian Kolat, Żaneta Kaluzińska, Andrzej K. Bednarek, Elżbieta Pluciennik
    Academic press:
    Bioscience Reports (year: 2019, volume: 15 (39), pages: BSR20181928), Publisher: Portland Press
    Status:
    Published
    DOI:
    10.1042/BSR20181928 – link to the publication

  5. In vitro and in silico assessment of the effect of WWOX expression on invasiveness pathways associated with AP-2 transcription factors in bladder cancer

    Authors:
    Żaneta Kałuzińska , Damian Kołat , Katarzyna Kośla , Magdalena Orzechowska , Andrzej K Bednarek , Elżbieta Płuciennik
    Academic press:
    BMC Urology (year: 2021, volume: 21, pages: 36), Publisher: Part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12894-021-00806-7 – link to the publication

Articles in post-conference publications (5)

  1. Determination of the WWOX gene function in AP-2gamma signaling pathway in metastatic bladder cancer

    Authors:
    E. Płuciennik, D. Kołat, Z. Kałuzinska, M. Orzechowska, K. Kosla, A. K. Bednarek
    Conference:
    FEBS (year: 2019, pages: 350), Publisher: 0.1002/2211-5463.12675
    Date:
    conference 6-11 lipiec
    Status:
    Published

  2. WWOX–AP-2α interaction affects biology of bladder cancer and demonstrates usefulness in its clinical features' discrimination

    Authors:
    Damian Kołat, Żaneta Kałuzińska, Elżbieta Płuciennik
    Conference:
    GLOBAL CONGRESS ON BLADDR CANCER (year: 2020, pages: 11,12), Publisher: e-HIMS bvba
    Date:
    conference 10-15 pażdziernik
    Status:
    Published

  3. WWOX may lose ability to regulate pro-tumoral AP-2γ but still possesses synergism with tumor suppressor AP-2α in high-grade bladder cancer.

    Authors:
    Kołat Damian, Kałuzińska Żaneta, Płuciennik Elżbieta
    Conference:
    XXIV Gliwice Scientific Meetings (year: 2020, pages: 67), Publisher: Association for the Support of Cancer Research Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch Silesian University of Technology
    Date:
    conference 20-21 listopada
    Status:
    Published

  4. Interakcje WWOX i AP-2γ w raku pęcherza moczowego - analizy in vitro oraz in silico

    Authors:
    Damian Kołat, Żaneta Kałuzińska, Elżbieta Płuciennik
    Conference:
    I Interdyscyplinarnej Konferencji Doktorantów Uniwersytetu Medycznego w Łodz iDocUMED (year: 2020, pages: 39), Publisher: Uniwersytet Medyczny w Łodzi
    Date:
    conference 7 listopada
    Status:
    Published

  5. The regulation of AP2-α transcription factor via WWOX protein and its influence in bladder carcinogenesis

    Authors:
    Żaneta Kałuzińska, Damian Kołat, Magdalena Orzechowska, Elżbieta Płuciennik
    Conference:
    Symbioza , 8 Intercollegiate Biotechnology Symposium (year: 2019, pages: 94), Publisher: Wydział Biologii UW,
    Date:
    conference 17.05-19.05
    Status:
    Published

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