Toxicity of amphotericin B in the context of the plasma membrane lipid reorganiz

Toxicity of amphotericin B in the context of the plasma membrane lipid reorganization by the activity of ABC transporters in mammalian cells.

2016/21/B/NZ3/00343

Keywords

Descriptors

NZ3_1: Biologia komórki
NZ1_3: Biofizyka
NZ1_2: Biochemia

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Uniwersytet Wrocławski, Wydział Biotechnologii

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Tomasz Trombik

Number of co-investigators in the project: 6

Call

OPUS 11 – announced on 2016-03-15

Amount awarded: 635 340 PLN
Project start date: 2017-01-12
Project end date: 2020-07-11
Project duration: 42 months (the same as in the proposal)
Project status: Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

Dewar do przechowywania komórek LS750.
Kontroler temperatury CL-100.
System do elektroforezy żelowej (SDS-PAGE) białek wraz z zasilaniem. Cost: 10 000 PLN
System do elektrotransferu białek typu "semi-dry". Cost: 10 000 PLN
Wytrząsarka kołyskowa. Cost: 7 000 PLN
Łażnia wodna. Cost: 8 000 PLN

Information in the final report

Publication in academic press/journals (4)

Do ABC transporters regulate plasma membrane organization?

Authors:
Ambroise Wu, Karolina Wojtowicz, Stephane Savary, Yannick Hamon, Tomasz Trombik

Academic press:
Cellular and Molecular Biology Letters (year: 2020, volume: 25, pages: 0), Publisher: BMC Springer Nature

Status:
Published

DOI:
10.1007/s00018-019-03154-w. – link to the publication
ABCA1 transporter reduces amphotericin B cytotoxicity in mammalian cells

Authors:
Wu A, Grela E, Wójtowicz K, Filipczak N, Hamon Y, Luchowski R, Grudziński W, Raducka-Jaszul O, Gagoś M, Szczepaniak A, Chimini G, Gruszecki WI, Trombik T

Academic press:
Cellular and Molecular Life Sciences (year: 2019, volume: 76(24), pages: 4979-4994), Publisher: Springer

Status:
Published

DOI:
10.1007/s00018-019-03154-w – link to the publication
Spot variation Fluorescence Correlation Spectroscopy for analysis the diffusion of molecules at the plasma membrane of living cell

Authors:
Sébastien Mailfert, Karolina Wojtowicz, Sophie Brustlein, Ewa Blaszczak, Marcin Łukaszewicz, Didier Marguet, Tomasz Trombik

Academic press:
Journal of Visualized Experiments (year: 2020, volume: -, pages: -), Publisher: JoVE

Status:
Published

DOI:
10.3791/61823 – link to the publication
Molecular Diffusion of ABCA1 at the Cell Surface of Living Cells Assessed by svFCS

Authors:
Olga Raducka-Jaszul, Karolina Wójtowicz, Aleksander F. Sikorski, Giovanna Chimini, Yannick Hamon, Tomasz Trombik

Academic press:
Membranes (year: 2021, volume: 11(7) 498, pages: -), Publisher: MDPI

Status:
Published

DOI:
10.3390/membranes11070498 – link to the publication

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