Zmiana języka

Projects search

In search of novel metfomin's prodrugs. Biocompatibility and pharmacokinetic in vitro studies.

2016/21/D/NZ7/01548

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Medyczny w Łodzi, Wydział Farmaceutyczny, Katedra Chemii Farmaceutycznej, Zakład Chemii Farmaceutycznej, Analizy Leków i Radiofarmacji

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Magdalena Justyna Markowicz-Piasecka

Number of co-investigators in the project: 3

Call

SONATA 11 – announced on 2016-03-15

Amount awarded
701 500 PLN
Project start date
2017-01-18
Project end date
2020-01-17
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator do hodowli komórkowych (5% CO2, 37 stopni C). Cost: 42 000 PLN
  2. Loża z laminarnym nawiewem powietrza. Cost: 50 000 PLN
  3. Mieszadło magnetyczne z grzaniem. Cost: 3 200 PLN
  4. Mikroskop z kontrastem fazowym wyposażony w kamerę. Cost: 28 000 PLN
  5. Naczynie dewar.
  6. Palnik gazowy.
  7. Pipety wielokanałowe (plus serwisowanie i kalibracja). Cost: 6 000 PLN
  8. Próżniowy system ssący. Cost: 8 000 PLN
  9. Wirówka laboratoryjna z chłodzeniem wraz z rotorami. Cost: 17 000 PLN
  10. Wyparka rotacyjna z pompą próżniową. Cost: 20 000 PLN
  11. Wytrząsarka z adapterem do mikropłytek.
  12. pH-metr. Cost: 2 500 PLN
  13. Łaźnia wodna z termostatem. Cost: 3 500 PLN

Information in the final report

Publication in academic press/journals (10)

  1. Sulfenamide and sulfonamide derivatives of metformin can exert anticoagulant and profibrinolytic properties

    Authors:
    Magdalena Markowicz-Piasecka, Kristiina M. Huttunen, Łukasz Mateusiak, Elżbieta Mikiciuk-Olasik, Joanna Sikora.
    Academic press:
    Chemico-Biological Interactions (year: 2018, volume: 284, pages: 126-136), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cbi.2018.02.012 – link to the publication

  2. Metformin – a Future Therapy for Neurodegenerative Diseases

    Authors:
    M. Markowicz-Piasecka, J. Sikora, A. Szydłowska, A. Skupień, E. Mikiciuk-Olasik, K. Huttunen
    Academic press:
    Pharmaceutical Research (year: 2017, volume: 34, pages: 2614-2627), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s11095-017-2199-y – link to the publication

  3. Biocompatible sulfenamide and sulfonamide derivatives of metformin can exert beneficial effects on plasma haemostasis

    Authors:
    M. Markowicz-Piasecka, K. Huttunen, E. Mikiciuk-Olasik, J. Sikora
    Academic press:
    Chemico-Biological Interactions (year: 2018, volume: 280, pages: 15-27), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cbi.2017.12.005 – link to the publication

  4. Sulfenamide and sulfonamide derivatives of metformin – a new option to improve endothelial function and plasma haemostasis.

    Authors:
    M. Markowicz-Piasecka, K. Huttunen, M. Broncel, J. Sikora.
    Academic press:
    Scientific Reports (year: 2019, volume: -, pages: 6573), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-019-43083-z. – link to the publication

  5. Novel halogenated sulfonamide biguanides with anti-coagulation properties.

    Authors:
    M. Markowicz-Piasecka, J. Sikora, A. Zajda, K. Huttunen.
    Academic press:
    Bioorganic Chemistry (year: 2019, volume: -, pages: -), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2019.103444. – link to the publication

  6. Sulfenamide derivatives can improve transporter-mediated cellular uptake of metformin and induce cytotoxicity in human breast adenocarcinoma cell lines.

    Authors:
    M. Markowicz-Piasecka, J. Huttunen, J. Sikora, K. Huttunen.
    Academic press:
    Bioorganic Chemistry (year: 2019, volume: 87, pages: 321-334), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2019.03.036. – link to the publication

  7. New prodrugs of metformin do not influence the overall haemostasis potential and integrity of the erythrocyte membrane

    Authors:
    M. Markowicz-Piasecka, J. Sikora, Ł. Mateusiak, E. Mikiciuk-Olasik, K. Huttunen.
    Academic press:
    European Journal of Pharmacology (year: 2017, volume: 811, pages: 208-221), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2017.06.011 – link to the publication

  8. Pleiotropic Activity of Metformin and Its Sulfonamide Derivatives on Vascular and Platelet Haemostasis

    Authors:
    M. Markowicz-Piasecka, K. Huttunen, A. Sadkowska, J. Sikora.
    Academic press:
    Molecules (year: 2020, volume: 125, pages: -), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25010125 – link to the publication

  9. An investigation into the pleiotropic activity of metformin. A glimpse of haemostasis.

    Authors:
    M. Markowicz-Piasecka, A. Sadkowska, K. Huttunen, M. Podsiedlik, E. Mikiciuk-Olasik, J. Sikora.
    Academic press:
    European Journal of Pharmacology (year: 2020, volume: 872, pages: 172984), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2020.172984 – link to the publication

  10. Effective Cellular Transport of Ortho-Halogenated Sulfonamide Derivatives of Metformin Is Related to Improved Antiproliferative Activity and Apoptosis Induction in MCF-7 Cells

    Authors:
    Magdalena Markowicz-Piasecka, Ibrahim Komeil, Johanna Huttunen, Joanna Sikora, Kristiina M. Huttunen
    Academic press:
    International Journal of Molecular Sciences (year: 2020, volume: 21, pages: 46051), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21072389 – link to the publication

Articles in post-conference publications (3)

  1. Model oceny biozgodności proleków metforminy.

    Authors:
    J. Sikora, Ł. Mateusiak, E. Mikiciuk-Olasik, M. Markowicz-Piasecka.
    Conference:
    XXIII Naukowy Zjazd Polskiego Towarzystwa Farmaceutycznego Farmacja w Polsce perspektywy nauki i zawodu (year: 2017, pages: 369), Publisher: Polskie Towarzystwo Farmaceutyczne
    Date:
    conference 19 - 22 września
    Status:
    Published

  2. Sulfenamide Derivatives Can Improve Oct-Mediated Cellular Uptake of Metformin

    Authors:
    M. Markowicz-Piasecka, J. Huttunen, K. M. Huttunen
    Conference:
    Inaugural Conference The Transporter Transition (year: 2018, pages: 119), Publisher: University Clinic of Dentistry Vienna
    Date:
    conference 18 – 21 września
    Status:
    Published

  3. Synteza i ocena aktywności biologicznej sulfonamidowych pochodnych metforminy.

    Authors:
    M. Markowicz-Piasecka, M. Podsiedlik, J. Sikora, K. Huttunen.
    Conference:
    Szkoła Chemii Medycznej (year: 2019, pages: K-6), Publisher: Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu
    Date:
    conference 25 - 27 września 2019
    Status:
    Published

« New search

Graphic design and implementation: Jakub Piotrowski