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Tuning anticancer properties of ruthenium polypyridyl complexes towards antimetastatic activity

2016/21/B/NZ7/01081

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia
  • ST5_16: Chemia biologiczna
  • NZ3_1: Biologia komórki

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Jagielloński, Wydział Chemii

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Małgorzata Brindell

Number of co-investigators in the project: 10

Call

OPUS 11 – announced on 2016-03-15

Amount awarded
1 191 320 PLN
Project start date
2017-02-09
Project end date
2021-02-08
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Miniwytrząsarka typu Vortex.
  2. System do ilościowej analizy żywych komórek w czasie rzeczywistym, składający się z mikroskopu zamontowanego na suwnicy, który umieszczony jest w inkubatorze do komórek, a także z sieciowego kontrolera zewnętrznego, który gromadzi, przetwarza i analizuje dane pochodzące z przekazywanego obrazu.. Cost: 390 000 PLN
  3. System do ilościowej analizy żywych komórek w czasie rzeczywistym, składający się z mikroskopu zmotoryzowanego zintegrowanego z zaciemnionym inkubatorem wyposażonym w kontrolery temperatury i stężenia dwutlenku węgla oraz tlenu wraz z oprogramowaniem umożliwiającym gromadzenie, przetwarzanie i analizę danych pochodzących z przekazywanego obrazu.

Information in the final report

Publication in academic press/journals (6)

  1. Versatile impact of serum proteins on ruthenium(II) polypyridyl complexes properties - opportunities and obstacles

    Authors:
    O. Mazuryk, P. Gajda-Morszewski , M. Brindell
    Academic press:
    Current Proteins and Peptides Science (year: 2019, volume: 20, pages: 1052-1059), Publisher: BenthamScience
    Status:
    Published
    DOI:
    10.2174/1389203720666190513090851 – link to the publication

  2. Moving Ru polypyridyl complexes beyond cytotoxic activity towards metastasis inhibition

    Authors:
    M. Brindell, I. Gurgul , E. Janczy-Cempa , P. Gajda-Morszewski , O. Mazuryk
    Academic press:
    Journal of Inorganic Biochemistry (year: 2022, volume: 226 art. 111652, pages: 46032), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2021.111652 – link to the publication

  3. Induction of transferrin aggregation by indazolium [tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) and its biological functon

    Authors:
    K. Śpiewak, S. Świątek, B. Jachimska, M. Brindell
    Academic press:
    New J Chem (year: 2019, volume: 43, pages: 11296-11306), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c9nj01342c – link to the publication

  4. Inhibition of Matrix Metalloproteinases and Cancer Cell Detachment by Ru(II) Polypyridyl Complexes Containing 4,7-Diphenyl-1,10-phenanthroline Ligands—New Candidates for Antimetastatic Agents

    Authors:
    P. Gajda-Morszewski, I. Gurgul, E. Janczy-Cempa, O. Mazuryk, M. Łomzik, M. Brindell
    Academic press:
    Pharmaceuticals (year: 2021, volume: 14 art 1014, pages: 46034), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ph14101014 – link to the publication

  5. Unexplored features of Ru(II) polypyridyl complexes – towards combined cytotoxic and antimetastatic activity

    Authors:
    Ilona Gurgul, Olga Mazuryk, Michał Łomzik, Philippe C. Gros, Dorota Rutkowska-Zbik, Małgorzata Brindell
    Academic press:
    Metallomics (year: 2020, volume: 12, pages: 784-793), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d0mt00019a – link to the publication

  6. New ruthenium compounds bearing semicarbazone 2-formylopyridine moiety: Playing with auxiliary ligands for tuning the mechanism of biological activity

    Authors:
    M. Łomzik, O. Mazuryk, D. Rutkowska-Zbik, G. Stochel, P.C. Gros, M. Brindell
    Academic press:
    J Inorg. Biochem (year: 2017, volume: 175, pages: 80-91), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2017.07.006 – link to the publication

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