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The impact of intracellular distribution and endocytic transport of lymphotoxin beta receptor (LTbetaR) on its signaling

2016/21/B/NZ3/03637

Keywords:

endocytosis signaling lymphotoxin beta receptor

Descriptors:

  • NZ3_7: Signal transduction
  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Magdalena Banach-Orłowska 

Number of co-investigators in the project: 5

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 996 125 PLN

Project start date (Y-m-d): 2017-03-31

Project end date (Y-m-d): 2020-12-30

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. The topology of lymphotoxin β receptor accumulated upon endolysosomal dysfunction dictates the NF-κB signaling outcome.
    Authors:
    Banach-Orłowska M, Jastrzębski K, Cendrowski J, Maksymowicz M, Wojciechowska K, Korostyński M, Moreau D, Gruenberg J, Miaczynska M.
    Academic press:
    Journal of Cell Science (rok: 2018, tom: 131(22), strony: 45304), Wydawca: The Company of Biologists
    Status:
    Published
    DOI:
    10.1242/jcs.218883 - link to the publication
  2. Cholesterol restricts lymphotoxin β receptor-triggered NF-κB signaling
    Authors:
    Banach-Orłowska M, Wyszyńska R, Pyrzyńska B, Maksymowicz M, Gołąb J, Miączyńska M.
    Academic press:
    Cell Communication and Signaling (rok: 2019, tom: 0,827083333333333, strony: 45310), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12964-019-0460-1 - link to the publication
  3. Clathrin- and dynamin-dependent endocytosis limits canonical NF-κB signaling triggered by lymphotoxin β receptor
    Authors:
    Małgorzata Maksymowicz, Marta Miączyńska, Magdalena Banach-Orłowska
    Academic press:
    Cell Communication and Signaling (rok: 2020, tom: 0,872222222222222, strony: 45312), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12964-020-00664-0 - link to the publication

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