Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Mechanisms modulating expression of HIF-1 transcription factor in proximal tubules and its importance for the regulation of renal gluconeogenesis - studies with reference to diabetic nephropathy

2016/21/B/NZ3/00365

Keywords:

hypoxia HIF-1 gluconeogenesis NADPH oxidase redox state renal proximal tubules hyperglycemia diabetes nephropathy

Descriptors:

  • NZ3_7: Signal transduction
  • NZ4_11: Metabolism

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Warszawski, Wydział Biologii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Katarzyna Winiarska 

Number of co-investigators in the project: 6

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 694 800 PLN

Project start date (Y-m-d): 2017-03-07

Project end date (Y-m-d): 2021-12-06

Project duration:: 57 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komora do inkubacji i pracy z komórkami w warunkach hipoksji (np. InvivO2 400 firmy Baker-Ruskinn) (175 000 PLN)
  2. Łaźnia wodna z wyposażeniem (np. Premium WB 10L firmy PolyScience) (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (1)
  1. Czynnik transkrypcyjny ChREBP – koordynator metabolizmu węglowodanów i lipidów
    Authors:
    Joanna Krawczak, Aleksandra Owczarek, Katarzyna Winiarska
    Academic press:
    Postepy Biochemii (rok: 2020, tom: 66 (1), strony: 45299), Wydawca: PTBioch
    Status:
    Published
    DOI:
    10.18388/pb.2019_282 - link to the publication
  2. Hypoxia increases the rate of renal gluconeogenesis via hypoxia-inducible factor-1-dependent activation of phosphoenolpyruvate carboxykinase expression
    Authors:
    Aleksandra Owczarek, Katarzyna Gieczewska, Robert Jarzyna, Adam K. Jagielski, Anna Kiersztan, Andrzej Gruza, Katarzyna Winiarska
    Academic press:
    Biochimie (rok: 2020, tom: 171-172, strony: 31-37), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biochi.2020.02.002 - link to the publication
  3. Transcription factor ChREBP mediates high glucose-evoked increase in HIF-1α content in epithelial cells of renal proximal tubules
    Authors:
    Aleksandra Owczarek, Katarzyna B. Gieczewska, Robert Jarzyna, Zuzanna Frydzinska, Katarzyna Winiarska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 13299), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222413299 - link to the publication
  4. HIF - czynnik transkrypcyjny na miarę Nagrody Nobla 2019
    Authors:
    Andrzej Gruza, Katarzyna Winiarska
    Academic press:
    Kosmos (rok: 2020, tom: 69 (2), strony: 269-276), Wydawca: Polskie Towarzystwo Przyrodników im. Kopernika
    Status:
    Published
    DOI:
    brak - link to the publication
  5. Sirtuiny i ich rola w regulacji metabolizmu
    Authors:
    Zuzanna Frydzińska, Aleksandra Owczarek, Katarzyna Winiarska
    Academic press:
    Postępy Biochemii (rok: 2019, tom: 65 (1), strony: 31-40), Wydawca: PTBioch
    Status:
    Published
    DOI:
    10.18388/pb.2019_254 - link to the publication
  6. Melatonin lowers HIF-1α content in human proximal tubular cells (HK-2) due to preventing its deacetylation by sirtuin 1
    Authors:
    Aleksandra Owczarek, Katarzyna Gieczewska, Marta Polanska, Bohdan Paterczyk, Andrzej Gruza, Katarzyna Winiarska
    Academic press:
    Frontiers in Physiology (rok: 2021, tom: 11, strony: 572911), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fphys.2020.572911 - link to the publication
  1. Hypoxia increases the rate of renal gluconeogenesis via hypoxia-inducible factor-1 (HIF-1) dependent activation of phosphoenolpyruvate carboxykinase (PEPCK) expression
    Authors:
    Aleksandra Owczarek, Katarzyna Gieczewska, Robert Jarzyna, Adam K. Jagielski, Andrzej Gruza, Katarzyna Winiarska
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: FEBSPress
    Data:
    konferencja 6-11 czerwca 2019
    Status:
    Published

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