Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The molecular effects of human mitochondrial cytochrome b mutations studied in bacterial Rhodobacter capsulatus cytochrome b model protein.

2016/21/B/NZ1/00294

Keywords:

cytochrome bc1 cytochrome b complex III mitochondrial mutations molecular effects

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry
  • NZ1_3: Biophysics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Arkadiusz Borek 

Number of co-investigators in the project: 4

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 895 900 PLN

Project start date (Y-m-d): 2017-02-13

Project end date (Y-m-d): 2021-02-12

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Spektrofluorymetr perkin elmer LS-55 (90 000 PLN)
  2. Napęd pneumatyczny OPT-20P do SFA-20mxM (30 000 PLN)
  3. Wirówka laboratoryjna Sorvall ST 40R z wyposażeniem.
  4. Urządzenie do szybkiego mieszania reagentów SFA-20mxM (70 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. Significant production of superoxide at the Qi site of cytochrome bc1: enhanced generation of matrix ROS in mitochondrial disease-related mutation I49P
    Authors:
    Arkadiusz Borek, Jakub Pagacz, Agnieszka Broniec, Rafał Pietras, Anna Pawlak, Sebastian Pintscher
    Academic press:
    Journal of Biological Chemistry , Wydawca: American Society for Biochemistry and Molecular Biology (United States)
    Status:
    Submitted
    DOI:
    brak - link to the publication
  2. ROS signaling capacity of cytochrome bc1: Opposing effects of adaptive and pathogenic mitochondrial mutations
    Authors:
    Jakub Pagacz, Agnieszka Broniec, Małgorzata Wolska, Artur Osyczka, Arkadiusz Borek
    Academic press:
    Free Radical Biology and Medicine (rok: 2021, tom: 163, strony: 243-254), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2020.12.019 - link to the publication

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