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Znaczenie kinazy sfingozyny 1 oraz sfingozyno-1-fosforanu w doświadczalnym modelu choroby Parkinsona oraz w farmakologicznej cytoprotekcji.

2016/20/T/NZ3/00504

Keywords:

Descriptors:

  • NZ3_7: Signal transduction
  • NZ3_5: Molecular neurobiology
  • NZ7_12: Prevention of human diseases

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Joanna Motyl 

Number of co-investigators in the project: 2

Call: ETIUDA 4 - announced on 2015-12-15

Amount awarded: 64 676 PLN

Project start date (Y-m-d): 2016-10-01

Project end date (Y-m-d): 2017-09-30

Project duration:: 12 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (1)
  1. Pramipexole and Fingolimod exert neuroprotection in a mouse model of Parkinson's disease by activation of sphingosine kinase 1 and Akt kinase
    Authors:
    Motyl J, Przykaza L, Boguszewski PM, Kosson P, Strosznajder JB.
    Academic press:
    Neuropharmacology (rok: 2018, tom: 135, strony: 139-150), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2018.02.023. - link to the publication
  2. Sphingosine kinase 1/sphingosine-1-phosphate receptors dependent signalling in neuronal diseases. The promising target for neuroprotection in Parkinson's disease
    Authors:
    Motyl J, Strosznajder JB.
    Academic press:
    Pharmacological Reports (rok: 2018, tom: 70, strony: 1010–1014), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1016/j.pharep.2018.05.002. - link to the publication
  1. Alteration of bioactive sphingolipids signalling and locomotor function in an animal model of Parkinson's disease. Neuroprotective effect of Fingolimod
    Authors:
    Motyl J, Strosznajder JB.
    Conference:
    Neurochemical Conference 2017 Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches (rok: 2017, ), Wydawca: TERMEDIA PUBLISHING HOUSE LTD
    Data:
    konferencja 19-20.10.2017
    Status:
    Published

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