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Synthesis, physicochemical and biological properties of thymosin beta4 - boron cluster conjugates. New strategy of improvement of pharmacokinetic parameters of therapeutic peptides.

2015/19/N/NZ7/02726

Keywords:

boron clusters dodecaborate anion cobalt bis(dicarollide) thymosin beta4

Descriptors:

  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Krzysztof Fink 

Number of co-investigators in the project: 2

Call: PRELUDIUM 10 - announced on 2015-09-15

Amount awarded: 49 800 PLN

Project start date (Y-m-d): 2016-06-17

Project end date (Y-m-d): 2017-06-16

Project duration:: 12 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Icosahedral boron clusters as modifying entities for biomolecules
    Authors:
    Tomasz M. Goszczyński, Krzysztof Fink, Janusz Boratyński
    Academic press:
    Expert Opinion on Biological Therapy (rok: 2018, tom: 18, strony: 205-213), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1080/14712598.2018.1473369 - link to the publication
  2. Interactions of Boron Clusters and their Derivatives with Serum Albumin
    Authors:
    Tomasz M. Goszczyński, Krzysztof Fink, Konrad Kowalski, Zbigniew J. Leśnikowski, Janusz Boratyński
    Academic press:
    Scientific Reports (rok: 2017, tom: 7, strony: 9800), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-017-10314-0 - link to the publication
  3. Synthesis and Biological Activity of Thymosin β4-Anionic Boron Cluster Conjugates
    Authors:
    Krzysztof Fink, Kamil Kobak, Monika Kasztura, Janusz Boratyński, Tomasz M. Goszczyński
    Academic press:
    Bioconjugate Chemistry (rok: 2018, tom: 29, strony: 3509-3515), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.bioconjchem.8b00646 - link to the publication

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