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Identification of the molecular pathways controlling development of the pathogenic and non-pathogenic T helper lymphocytes during autoimmune demyelination

2015/19/B/NZ6/02834

Keywords

Descriptors

  • NZ6_1: Odporność swoista i nieswoista
  • NZ4_9: Neurobiologia systemowa
  • NZ5_3: Patogeneza chorób człowieka

Panel

NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution

Uniwersytet Medyczny w Łodzi, Katedra Neurologii

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Marcin Przemysław Mycko

Number of co-investigators in the project: 6

Call

OPUS 10 – announced on 2015-09-15

Amount awarded
1 188 400 PLN
Project start date
2016-08-29
Project end date
2019-08-28
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Mouse cages exchange system for transgenic and control mice. Cost: 23 000 PLN
  2. Stacja komputerowa do przechowywania i analizy danych miRNA-seq. Cost: 7 000 PLN
  3. System indiwidualnej wentylacji dla myszy transgenicznych i myszy kontrolnych. Cost: 100 000 PLN

Information in the final report

Publication in academic press/journals (5)

  1. The role of exosomes in CNS inflammation and their involvement in multiple sclerosis.

    Authors:
    Selmaj I, Mycko MP, Raine CS, Selmaj KW
    Academic press:
    Journal of Neuroimmunology (year: 2017, volume: 306, pages: 46032), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jneuroim.2017.02.002 – link to the publication

  2. microRNA and exosome profiling in multiple sclerosis.

    Authors:
    Mycko MP, Baranzini SE
    Academic press:
    Multiple Sclerosis Journal (year: 2020, volume: in press, pages: 46028), Publisher: SAGE Publications 2455 Teller Road Thousand Oaks, CA 91320
    Status:
    Published
    DOI:
    10.1177/1352458519879303 – link to the publication

  3. Multiple sclerosis: Serum-derived exosomes express myelin proteins

    Authors:
    Galazka G, Mycko MP, Selmaj I, Raine CS, Selmaj KW
    Academic press:
    Multiple Sclerosis (year: 2018, volume: 24, pages: 449-458), Publisher: SAGE Journals tom
    Status:
    Published
    DOI:
    10.1177/1352458517696597 – link to the publication

  4. Global exosome transcriptome profiling reveals biomarkers for multiple sclerosis.

    Authors:
    Selmaj I, Cichalewska M, Namiecinska M, Galazka G, Horzelski W, Selmaj KW, Mycko MP
    Academic press:
    Annals of Neurology 11,089 (year: 2017, volume: 81, pages: 703-717), Publisher: Wiely
    Status:
    Published
    DOI:
    10.1002/ana.24931 – link to the publication

  5. The Heat Shock Protein HSP70 Promotes Th17 Genes' Expression via Specific Regulation of microRNA

    Authors:
    Hanna Cwiklinska, Maria Cichalewska-Studzinska, KrzysztofW. Selmaj, Marcin P. Mycko
    Academic press:
    International Journal of Molecular Sciences (year: 2020, volume: 21, pages: 2823), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21082823 – link to the publication

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