Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Identification of the molecular pathways controlling development of the pathogenic and non-pathogenic T helper lymphocytes during autoimmune demyelination

2015/19/B/NZ6/02834

Keywords:

Th17 cells Tr1 cells non-coding RNA autoimmune demyelination experimental autoimmune demyelination multiple sclerosis

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ4_9: Systems neurobiology
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Medyczny w Łodzi, Katedra Neurologii

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marcin Mycko 

Number of co-investigators in the project: 6

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 1 188 400 PLN

Project start date (Y-m-d): 2016-08-29

Project end date (Y-m-d): 2019-08-28

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. System indiwidualnej wentylacji dla myszy transgenicznych i myszy kontrolnych (100 000 PLN)
  2. Mouse cages exchange system for transgenic and control mice (23 000 PLN)
  3. Stacja komputerowa do przechowywania i analizy danych miRNA-seq (7 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Global exosome transcriptome profiling reveals biomarkers for multiple sclerosis.
    Authors:
    Selmaj I, Cichalewska M, Namiecinska M, Galazka G, Horzelski W, Selmaj KW, Mycko MP
    Academic press:
    Annals of Neurology 11,089 (rok: 2017, tom: 81, strony: 703-717), Wydawca: Wiely
    Status:
    Published
    DOI:
    10.1002/ana.24931 - link to the publication
  2. Multiple sclerosis: Serum-derived exosomes express myelin proteins
    Authors:
    Galazka G, Mycko MP, Selmaj I, Raine CS, Selmaj KW
    Academic press:
    Multiple Sclerosis (rok: 2018, tom: 24, strony: 449-458), Wydawca: SAGE Journals tom
    Status:
    Published
    DOI:
    10.1177/1352458517696597 - link to the publication
  3. The Heat Shock Protein HSP70 Promotes Th17 Genes' Expression via Specific Regulation of microRNA
    Authors:
    Hanna Cwiklinska, Maria Cichalewska-Studzinska, KrzysztofW. Selmaj, Marcin P. Mycko
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 2823), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21082823 - link to the publication
  4. microRNA and exosome profiling in multiple sclerosis.
    Authors:
    Mycko MP, Baranzini SE
    Academic press:
    Multiple Sclerosis Journal (rok: 2020, tom: in press, strony: 45297), Wydawca: SAGE Publications 2455 Teller Road Thousand Oaks, CA 91320
    Status:
    Published
    DOI:
    10.1177/1352458519879303 - link to the publication
  5. The role of exosomes in CNS inflammation and their involvement in multiple sclerosis.
    Authors:
    Selmaj I, Mycko MP, Raine CS, Selmaj KW
    Academic press:
    Journal of Neuroimmunology (rok: 2017, tom: 306, strony: 45301), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jneuroim.2017.02.002 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy