Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Identification of the molecular pathways controlling development of the pathogenic and non-pathogenic T helper lymphocytes during autoimmune demyelination

2015/19/B/NZ6/02834

Keywords:

Th17 cells Tr1 cells non-coding RNA autoimmune demyelination experimental autoimmune demyelination multiple sclerosis

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ4_9: Systems neurobiology
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Medyczny w Łodzi, Katedra Neurologii

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marcin Mycko 

Number of co-investigators in the project: 6

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 1 188 400 PLN

Project start date (Y-m-d): 2016-08-29

Project end date (Y-m-d): 2019-08-28

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Stacja komputerowa do przechowywania i analizy danych miRNA-seq (7 000 PLN)
  2. System indiwidualnej wentylacji dla myszy transgenicznych i myszy kontrolnych (100 000 PLN)
  3. Mouse cages exchange system for transgenic and control mice (23 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Multiple sclerosis: Serum-derived exosomes express myelin proteins
    Authors:
    Galazka G, Mycko MP, Selmaj I, Raine CS, Selmaj KW
    Academic press:
    Multiple Sclerosis (rok: 2018, tom: 24, strony: 449-458), Wydawca: SAGE Journals tom
    Status:
    Published
    DOI:
    10.1177/1352458517696597 - link to the publication
  2. The Heat Shock Protein HSP70 Promotes Th17 Genes' Expression via Specific Regulation of microRNA
    Authors:
    Hanna Cwiklinska, Maria Cichalewska-Studzinska, KrzysztofW. Selmaj, Marcin P. Mycko
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 2823), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21082823 - link to the publication
  3. Global exosome transcriptome profiling reveals biomarkers for multiple sclerosis.
    Authors:
    Selmaj I, Cichalewska M, Namiecinska M, Galazka G, Horzelski W, Selmaj KW, Mycko MP
    Academic press:
    Annals of Neurology 11,089 (rok: 2017, tom: 81, strony: 703-717), Wydawca: Wiely
    Status:
    Published
    DOI:
    10.1002/ana.24931 - link to the publication
  4. The role of exosomes in CNS inflammation and their involvement in multiple sclerosis.
    Authors:
    Selmaj I, Mycko MP, Raine CS, Selmaj KW
    Academic press:
    Journal of Neuroimmunology (rok: 2017, tom: 306, strony: 45301), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jneuroim.2017.02.002 - link to the publication
  5. microRNA and exosome profiling in multiple sclerosis.
    Authors:
    Mycko MP, Baranzini SE
    Academic press:
    Multiple Sclerosis Journal (rok: 2020, tom: in press, strony: 45297), Wydawca: SAGE Publications 2455 Teller Road Thousand Oaks, CA 91320
    Status:
    Published
    DOI:
    10.1177/1352458519879303 - link to the publication

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