Projects search

Fat and Sugar-A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease.

Authors:

Simoes I.C.M., Janikiewicz J., Bauer J., Karkucinska-Wieckowska A., Kalinowski P., Dobrzyń A., Wolski A., Pronicki M., Zieniewicz K., Dobrzyń P., Krawczyk M., Zischka H., Wieckowski M.R., Potes Y.

Academic press:

Nutrients (year: 2019, volume: 11(12), pages: 2871-2905), Publisher: MDPI

Status:

Published

DOI:

10.3390/nu11122871 – link to the publication

Oleic acid increases the transcriptional activity of FoxO1 by promoting its nuclear translocation and β-catenin binding in pancreatic β-cells.

Authors:

Jazurek-Ciesiolka M., Janikiewicz J. Dobrzyn P., Dziewulska A., Kozinski K. Dobrzyn A.

Academic press:

Biochimica et biophysica acta. Molecular basis of disease. (year: 2019, volume: 1865 (10), pages: 2753-2764), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.bbadis.2019.06.018 – link to the publication

Combinations of regenerative medicine and Lab-on-a-chip systems: New hope to restoring the proper function of pancreatic islets in diabetes

Authors:

Patrycja Sokolowska, Justyna Janikiewicz, Elzbieta Jastrzebska, Zbigniew Brzozka, Agnieszka Dobrzyn

Academic press:

Biosensors and bioelectronics (year: 2020, volume: 167, pages: 112451), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.bios.2020.112451 – link to the publication

Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of β-cell identity and α-cell expansion in the mature pancreas

Authors:

Aneta M. Dobosz, Justyna Janikiewicz, Ewelina Krogulec, Anna Dziewulska, Anna Ajduk, Marcin Szpila, Hanna Nieznańska, Andrzej A. Szczepankiewicz, Dorota Wypych ,Agnieszka Dobrzyn

Academic press:

Molecular Metabolism (year: 2023, volume: 67, pages: 101659), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.molmet.2022.101659 – link to the publication

Stearoyl-CoA Desaturase 1 Activity Determines the Maintenance of DNMT1-Mediated DNA Methylation Patterns in Pancreatic β-Cells

Authors:

Aneta M. Dobosz, Justyna Janikiewicz, Anna M. Borkowska, Anna Dziewulska, Ewelina Lipiec, Pawel Dobrzyn, Wojciech M. Kwiatek, Agnieszka Dobrzyn

Academic press:

International Journal of Molecular Sciences (year: 2020, volume: 21, pages: 6844), Publisher: MDPI

Status:

Published

DOI:

10.3390/ijms21186844 – link to the publication

Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics.

Authors:

Janikiewicz J., Szymański J., Malinska D., Patalas-Krawczyk P., Michalska B., Duszyński J., Giorgi C., Bonora M., Dobrzyn A., Wieckowski MR.

Academic press:

Cell Death and Disease (year: 2018, volume: 9, pages: 332), Publisher: Nature Publishing Group, London, UK

Status:

Published

DOI:

10.1038/s41419-017-0105-5 – link to the publication

Stearoyl-CoA desaturase 1 deficiency exacerbates palmitate-induced lipotoxicity by the formation of small lipid droplets in pancreatic β-cells

Authors:

Justyna Janikiewicz, Aneta M. Dobosz, Katarzyna Majzner, Tytus Bernaś, Agnieszka Dobrzyń

Academic press:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (year: 2023, volume: 1869, pages: 166711-166727), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.bbadis.2023.166711 – link to the publication

The Good, the Bad, and the Ugly – role of the pancreas, endothelium, and adipose tissue axis in the management of pancreatic β-cell failure in obesity-related type 2 diabetes

Authors:

Janikiewicz J., Pawelec P., Kucharczyk P., Dobrzyń A.

Academic press:

Advances in Biochemistry (year: 2018, volume: 64, pages: 166-174), Publisher: Polskie Towarzystwo Biochemiczne, Zarząd Główny

Status:

Published

DOI:

10.18388/pb.2018_127 – link to the publication

Interaction of Mitochondria with the Endoplasmic Reticulum and Plasma Membrane in Calcium Homeostasis, Lipid Trafficking and Mitochondrial Structure.

Authors:

Szymański J, Janikiewicz J, Michalska B, Patalas-Krawczyk P, Perrone M, Ziółkowski W, Duszyński J, Pinton P, Dobrzyń A, Więckowski MR.

Academic press:

International Journal of Molecular Sciences (year: 2017, volume: 18, pages: 1576), Publisher: MDPI AG, Basel, Switzerland

Status:

Published

DOI:

10.3390/ijms18071576 – link to the publication

Regulation of endothelial cells adhesion in pancreatic islets-role of long chain fatty acids

Authors:

Patrycja Kucharczyk, Justyna Janikiewicz, Agnieszka Dobrzyń

Conference:

25th Kraków Conference on Endothelium (year: 2017, pages: 68), Publisher: nie dotyczy

Date:

conference 20-21.10

Status:

Published

Stearoyl-CoA desaturase 1 affects lipid droplet proteome and lipidome in palmitate-induced lipotoxicity of pancreatic β-cells

Authors:

Justyna Janikiewicz, Paulina Pawelec, Tytus Bernaś, Agnieszka Dobrzyń

Conference:

5th BBDC-Joslin-UCPH conference Prevention of Beta Cell Dysfunction in T1D and T2D: Role of Inter-organ Communication, (year: 2018, pages: poster P38, książka abstraktów strona 47), Publisher: nie dotyczy

Date:

conference 26-27.10

Status:

Published

Role of stearoyl-CoA desaturase 1 in management of lipid droplet proteome and lipidome during palmitate-induced lipotoxicity of pancreatic β-cells

Authors:

Justyna Janikiewicz, Paulina Pawelec, Tytus Bernaś, Agnieszka Dobrzyń

Conference:

EASD Islet Study Group Molecular Aspects of Pancreatic Islet Function.The Beta Cell in Health, Disease and after Therapy (year: 2018, pages: poster P-12, książka abstraktów strona 44), Publisher: nie dotyczy

Date:

conference 5-7.10

Status:

Published

Diminished activity of stearoyl-CoA desaturase 1 affects lipid droplets proteome and lipidome in palmitate-derived lipotoxicity of pancreatic beta cells

Authors:

Justyna Janikiewicz, Tytus Bernaś, Agnieszka Dobrzyń

Conference:

5th Helmholtz - Nature Medicine Diabetes Conference (year: 2017, pages: sesja late breaking abstracts, prezentacja nr 22), Publisher: nie dotyczy

Date:

conference 17-19.09

Status:

Published

Islets therapeutic checkpoint: Inhibition of stearoyl‐CoA desaturase impairs lipid droplet morphology and metabolism during palmitotoxicity of pancreatic β‐cells

Authors:

Justyna Janikiewicz, Aneta M. Dobosz, Katarzyna Majzner, Tytus Bernas, Agnieszka Dobrzyn

Conference:

Experimental Biology 2020 (year: 2020, pages: Nr posteru: L9112), Publisher: Wiley

Date:

conference 04-07.04.2020

Status:

Published

DOI:

link to the publication

Stearoyl‐CoA desaturase 1 determines pancreatic β‐cell fate through regulation of DNA methylation pattern

Authors:

Aneta M. Dobosz, Justyna Janikiewicz, Anna M. Borkowska, Wojciech M. Kwiatek, Agnieszka Dobrzyn

Conference:

Experimental Biology 2020 (year: 2020, pages: Nr posteru: L9301), Publisher: Wiley

Date:

conference 04-07.04.2020

Status:

Published

DOI:

link to the publication

Diminished activity of stearoyl-CoA desaturase 1 affects lipid droplet remodeling in palmitotoxicity of pancreatic β-cells.

Authors:

Justyna Janikiewicz, Aneta Maria Dobosz, Tytus Bernaś, Paulina Pawelec, Agnieszka Dobrzyń

Conference:

60th International Conference on the Bioscience of Lipids (year: 2019, pages: poster P-159, książka abstraktów strona 239), Publisher: nie dotyczy

Date:

conference 2019-06-17-21

Status:

Published

Stearoyl-CoA desaturase 1- a novel player in regulation of pancreatic β-cell identity.

Authors:

Aneta Maria Dobosz, Justyna Janikiewicz, Anna Dziewulska, Katarzyna Kolczyńska, Agnieszka Dobrzyń

Conference:

60th International Conference on the Bioscience of Lipids (year: 2019, pages: Poster numer P-160, materiały zjazdowe strona 240), Publisher: nie dotyczy

Date:

conference 2019-06-17-21

Status:

Published

Sphingolipid mediators of cell signaling and metabolism, rozdział 19

Authors:

Agnieszka Dobrzyn, Justyna Janikiewicz, Zuzanna Tracz-Gaszewska, Anna Filip, Aneta M. Dobosz, Ewelina Krogulec, Pawel Dobrzyn

Book:

Lipid Signalling and Metabolism (year: 2020, volume: 1, pages: 385-411), Publisher: Elsevier, Academic Press

Status:

Published