Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Stearoyl-CoA desaturase 1 as a missing metabolic linker between lipid droplets storage and fatty acid-induced pancreatic beta cell failure

2015/19/D/NZ4/03705

Keywords:

SCD1 pancreatic beta cells neutral lipids phospholipids lipotoxicity lipophagy

Descriptors:

  • NZ4_2:
  • NZ4_11:
  • NZ4_6:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Justyna Janikiewicz 

Number of co-investigators in the project: 3

Call: SONATA 10 - announced on 2015-09-15

Amount awarded: 692 200 PLN

Project start date (Y-m-d): 2016-12-19

Project end date (Y-m-d): 2023-06-18

Project duration:: 78 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (12)
  • Articles in post-conference publications (11)
  • Book publications / chapters in book publications (1)
  1. Oleic acid increases the transcriptional activity of FoxO1 by promoting its nuclear translocation and β-catenin binding in pancreatic β-cells.
    Authors:
    Jazurek-Ciesiolka M., Janikiewicz J. Dobrzyn P., Dziewulska A., Kozinski K. Dobrzyn A.
    Academic press:
    Biochimica et biophysica acta. Molecular basis of disease. (rok: 2019, tom: 1865 (10), strony: 2753-2764), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2019.06.018 - link to the publication
  2. Interaction of Mitochondria with the Endoplasmic Reticulum and Plasma Membrane in Calcium Homeostasis, Lipid Trafficking and Mitochondrial Structure.
    Authors:
    Szymański J, Janikiewicz J, Michalska B, Patalas-Krawczyk P, Perrone M, Ziółkowski W, Duszyński J, Pinton P, Dobrzyń A, Więckowski MR.
    Academic press:
    International Journal of Molecular Sciences (rok: 2017, tom: 18, strony: 1576), Wydawca: MDPI AG, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ijms18071576 - link to the publication
  3. Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of β-cell identity and α-cell expansion in the mature pancreas
    Authors:
    Aneta M. Dobosz, Justyna Janikiewicz, Ewelina Krogulec, Anna Dziewulska, Anna Ajduk, Marcin Szpila, Hanna Nieznańska, Andrzej A. Szczepankiewicz, Dorota Wypych ,Agnieszka Dobrzyn
    Academic press:
    Molecular Metabolism (rok: 2023, tom: 67, strony: 101659), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molmet.2022.101659 - link to the publication
  4. The Good, the Bad, and the Ugly – role of the pancreas, endothelium, and adipose tissue axis in the management of pancreatic β-cell failure in obesity-related type 2 diabetes
    Authors:
    Janikiewicz J., Pawelec P., Kucharczyk P., Dobrzyń A.
    Academic press:
    Advances in Biochemistry (rok: 2018, tom: 64, strony: 166-174), Wydawca: Polskie Towarzystwo Biochemiczne, Zarząd Główny
    Status:
    Published
    DOI:
    10.18388/pb.2018_127 - link to the publication
  5. Fat and Sugar-A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease.
    Authors:
    Simoes I.C.M., Janikiewicz J., Bauer J., Karkucinska-Wieckowska A., Kalinowski P., Dobrzyń A., Wolski A., Pronicki M., Zieniewicz K., Dobrzyń P., Krawczyk M., Zischka H., Wieckowski M.R., Potes Y.
    Academic press:
    Nutrients (rok: 2019, tom: 11(12), strony: 2871-2905), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu11122871 - link to the publication
  6. Stearoyl-CoA Desaturase 1 Activity Determines the Maintenance of DNMT1-Mediated DNA Methylation Patterns in Pancreatic β-Cells
    Authors:
    Aneta M. Dobosz, Justyna Janikiewicz, Anna M. Borkowska, Anna Dziewulska, Ewelina Lipiec, Pawel Dobrzyn, Wojciech M. Kwiatek, Agnieszka Dobrzyn
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 6844), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21186844 - link to the publication
  7. Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics.
    Authors:
    Janikiewicz J., Szymański J., Malinska D., Patalas-Krawczyk P., Michalska B., Duszyński J., Giorgi C., Bonora M., Dobrzyn A., Wieckowski MR.
    Academic press:
    Cell Death and Disease (rok: 2018, tom: 9, strony: 332), Wydawca: Nature Publishing Group, London, UK
    Status:
    Published
    DOI:
    10.1038/s41419-017-0105-5 - link to the publication
  8. Stearoyl-CoA desaturase 1 deficiency exacerbates palmitate-induced lipotoxicity by the formation of small lipid droplets in pancreatic β-cells
    Authors:
    Justyna Janikiewicz, Aneta M. Dobosz, Katarzyna Majzner, Tytus Bernaś, Agnieszka Dobrzyń
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (rok: 2023, tom: 1869, strony: 166711-166727), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2023.166711 - link to the publication
  9. Combinations of regenerative medicine and Lab-on-a-chip systems: New hope to restoring the proper function of pancreatic islets in diabetes
    Authors:
    Patrycja Sokolowska, Justyna Janikiewicz, Elzbieta Jastrzebska, Zbigniew Brzozka, Agnieszka Dobrzyn
    Academic press:
    Biosensors and bioelectronics (rok: 2020, tom: 167, strony: 112451), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bios.2020.112451 - link to the publication
  10. Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of β-cell identity and α-cell expansion in the mature pancreas
    Authors:
    Aneta M. Dobosz, Justyna Janikiewicz, Ewelina Krogulec, Anna Dziewulska, Anna Ajduk, Marcin Szpila, Hanna Nieznańska, Andrzej A. Szczepankiewicz, Dorota Wypych ,Agnieszka Dobrzyn
    Academic press:
    Molecular Metabolism (rok: 2023, tom: 67, strony: 101659), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molmet.2022.101659 - link to the publication
  11. The Good, the Bad, and the Ugly – role of the pancreas, endothelium, and adipose tissue axis in the management of pancreatic β-cell failure in obesity-related type 2 diabetes
    Authors:
    Janikiewicz J., Pawelec P., Kucharczyk P., Dobrzyń A.
    Academic press:
    Advances in Biochemistry (rok: 2018, tom: 64, strony: 166-174), Wydawca: Polskie Towarzystwo Biochemiczne, Zarząd Główny
    Status:
    Published
    DOI:
    10.18388/pb.2018_127 - link to the publication
  12. Stearoyl-CoA desaturase 1 deficiency exacerbates palmitate-induced lipotoxicity by the formation of small lipid droplets in pancreatic β-cells
    Authors:
    Justyna Janikiewicz, Aneta M. Dobosz, Katarzyna Majzner, Tytus Bernaś, Agnieszka Dobrzyń
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (rok: 2023, tom: 1869, strony: 166711-166727), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2023.166711 - link to the publication
  1. Role of stearoyl-CoA desaturase 1 in management of lipid droplet proteome and lipidome during palmitate-induced lipotoxicity of pancreatic β-cells
    Authors:
    Justyna Janikiewicz, Paulina Pawelec, Tytus Bernaś, Agnieszka Dobrzyń
    Conference:
    EASD Islet Study Group "Molecular Aspects of Pancreatic Islet Function.The Beta Cell in Health, Disease and after Therapy" (rok: 2018, ), Wydawca: nie dotyczy
    Data:
    konferencja 5-7.10
    Status:
    Published
  2. Stearoyl‐CoA desaturase 1 determines pancreatic β‐cell fate through regulation of DNA methylation pattern
    Authors:
    Aneta M. Dobosz, Justyna Janikiewicz, Anna M. Borkowska, Wojciech M. Kwiatek, Agnieszka Dobrzyn
    Conference:
    Experimental Biology 2020 (rok: 2020, ), Wydawca: Wiley
    Data:
    konferencja 04-07.04.2020
    Status:
    Published
    DOI:
    link to the publication
  3. Stearoyl-CoA desaturase 1- a novel player in regulation of pancreatic β-cell identity.
    Authors:
    Aneta Maria Dobosz, Justyna Janikiewicz, Anna Dziewulska, Katarzyna Kolczyńska, Agnieszka Dobrzyń
    Conference:
    60th International Conference on the Bioscience of Lipids (rok: 2019, ), Wydawca: nie dotyczy
    Data:
    konferencja 2019-06-17-21
    Status:
    Published
  4. Regulation of endothelial cells adhesion in pancreatic islets-role of long chain fatty acids
    Authors:
    Patrycja Kucharczyk, Justyna Janikiewicz, Agnieszka Dobrzyń
    Conference:
    25th Kraków Conference on Endothelium (rok: 2017, ), Wydawca: nie dotyczy
    Data:
    konferencja 20-21.10
    Status:
    Published
  5. Stearoyl‐CoA desaturase 1 determines pancreatic β‐cell fate through regulation of DNA methylation pattern
    Authors:
    Aneta M. Dobosz, Justyna Janikiewicz, Anna M. Borkowska, Wojciech M. Kwiatek, Agnieszka Dobrzyn
    Conference:
    Experimental Biology 2020 (rok: 2020, ), Wydawca: Wiley
    Data:
    konferencja 04-07.04.2020
    Status:
    Published
    DOI:
    link to the publication
  6. Role of stearoyl-CoA desaturase 1 in management of lipid droplet proteome and lipidome during palmitate-induced lipotoxicity of pancreatic β-cells
    Authors:
    Justyna Janikiewicz, Paulina Pawelec, Tytus Bernaś, Agnieszka Dobrzyń
    Conference:
    EASD Islet Study Group "Molecular Aspects of Pancreatic Islet Function.The Beta Cell in Health, Disease and after Therapy" (rok: 2018, ), Wydawca: nie dotyczy
    Data:
    konferencja 5-7.10
    Status:
    Published
  7. Stearoyl-CoA desaturase 1 affects lipid droplet proteome and lipidome in palmitate-induced lipotoxicity of pancreatic β-cells
    Authors:
    Justyna Janikiewicz, Paulina Pawelec, Tytus Bernaś, Agnieszka Dobrzyń
    Conference:
    5th BBDC-Joslin-UCPH conference "Prevention of Beta Cell Dysfunction in T1D and T2D: Role of Inter-organ Communication", (rok: 2018, ), Wydawca: nie dotyczy
    Data:
    konferencja 26-27.10
    Status:
    Published
  8. Diminished activity of stearoyl-CoA desaturase 1 affects lipid droplets proteome and lipidome in palmitate-derived lipotoxicity of pancreatic beta cells
    Authors:
    Justyna Janikiewicz, Tytus Bernaś, Agnieszka Dobrzyń
    Conference:
    5th Helmholtz - Nature Medicine Diabetes Conference (rok: 2017, ), Wydawca: nie dotyczy
    Data:
    konferencja 17-19.09
    Status:
    Published
  9. Diminished activity of stearoyl-CoA desaturase 1 affects lipid droplet remodeling in palmitotoxicity of pancreatic β-cells.
    Authors:
    Justyna Janikiewicz, Aneta Maria Dobosz, Tytus Bernaś, Paulina Pawelec, Agnieszka Dobrzyń
    Conference:
    60th International Conference on the Bioscience of Lipids (rok: 2019, ), Wydawca: nie dotyczy
    Data:
    konferencja 2019-06-17-21
    Status:
    Published
  10. Stearoyl-CoA desaturase 1 affects lipid droplet proteome and lipidome in palmitate-induced lipotoxicity of pancreatic β-cells
    Authors:
    Justyna Janikiewicz, Paulina Pawelec, Tytus Bernaś, Agnieszka Dobrzyń
    Conference:
    5th BBDC-Joslin-UCPH conference "Prevention of Beta Cell Dysfunction in T1D and T2D: Role of Inter-organ Communication", (rok: 2018, ), Wydawca: nie dotyczy
    Data:
    konferencja 26-27.10
    Status:
    Published
  11. Islets therapeutic checkpoint: Inhibition of stearoyl‐CoA desaturase impairs lipid droplet morphology and metabolism during palmitotoxicity of pancreatic β‐cells
    Authors:
    Justyna Janikiewicz, Aneta M. Dobosz, Katarzyna Majzner, Tytus Bernas, Agnieszka Dobrzyn
    Conference:
    Experimental Biology 2020 (rok: 2020, ), Wydawca: Wiley
    Data:
    konferencja 04-07.04.2020
    Status:
    Published
    DOI:
    link to the publication
  1. Sphingolipid mediators of cell signaling and metabolism, rozdział 19
    Authors:
    Agnieszka Dobrzyn, Justyna Janikiewicz, Zuzanna Tracz-Gaszewska, Anna Filip, Aneta M. Dobosz, Ewelina Krogulec, Pawel Dobrzyn
    Book:
    Lipid Signalling and Metabolism (rok: 2020, tom: 1, strony: 385-411), Wydawca: Elsevier, Academic Press
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy