Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Searching for new mechanisms of NK cells defense against selected elements of immunosupressive tumor environment

2015/19/B/NZ6/02862

Keywords:

NK cells oxidative stress hypoxia

Descriptors:

  • NZ6_2: Clinical immunology
  • NZ6_1: Adaptive and innate immunity

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Warszawski Uniwersytet Medyczny, Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Magdalena Winiarska 

Number of co-investigators in the project: 5

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 1 390 680 PLN

Project start date (Y-m-d): 2016-07-08

Project end date (Y-m-d): 2021-07-07

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. terrmomixer.
  2. Wirówka z chłodzeniem (45 000 PLN)
  3. worteksy.
  4. Łaźnia wodna (2 sztuki) + kulki metalowe.
  5. Lodówka.
  6. Zamrażarka.
  7. Zbiornik do przechowywania materiałów biologicznych w ciekłym azocie (27 000 PLN)
  8. wyciąg chemiczny.

Information in the final report

  • Publication in academic press/journals (6)
  1. Harnessing altered oxidative metabolism in cancer by augmented prooxidant therapy.
    Authors:
    Firczuk M, Bajor M, Graczyk-Jarzynka A, Fidyt K, Goral A, Zagozdzon R.
    Academic press:
    Cancer Letters (rok: 2020, tom: 471, strony: 45302), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.canlet.2019.11.037 - link to the publication
  2. The Magic Bullet" Is Here? Cell-Based Immunotherapies for Hematological Malignancies in the Twilight of the Chemotherapy Era.
    Authors:
    Nina Miazek-Zapala, Aleksander Slusarczyk, Aleksandra Kusowska, Piotr Zapala, Matylda Kubacz, Magdalena Winiarska, Malgorzata Bobrowicz
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 45314), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10061511 - link to the publication
  3. The Tumor Microenvironment-A Metabolic Obstacle to NK Cells' Activity
    Authors:
    Domagala J, Lachota M, Klopotowska M, Graczyk-Jarzynka A, Domagala A, Zhylko A, Soroczynska K, Winiarska M.
    Academic press:
    Cancers (rok: 2020, tom: 12(12), strony: 13150), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12123542 - link to the publication
  4. Targeting Negative and Positive Immune Checkpoints with Monoclonal Antibodies in Therapy of Cancer
    Authors:
    Marhelava K, Pilch Z, Bajor M, Graczyk-Jarzynka A, Zagozdzon R.
    Academic press:
    Cancers (rok: 2019, tom: 11, strony: 45312), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers11111756 - link to the publication
  5. PRDX-1 supports the survival and antitumor activity of primary and CAR-modified NK cells under oxidative stress.
    Authors:
    Marta Klopotowska, Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Agnieszka Kraft, Zofia Pilch, Andriy Zhylko, Malgorzata Firczuk, Iwona Baranowska, Michal Lazniewski, Dariusz Plewczynski, Agnieszka Goral, Karolina Soroczynska, Joanna Domagala, Katsiaryna Marhelava, Aleksander Slusarczyk, Kuba Retecki, Kavita Ramji, Marta Krawczyk, Madison N Temples, Blanka Sharma, Mieszko Lachota, Herman Netskar , Karl-Johan Malmberg, Radoslaw Zagozdzon, Magdalena Winiarska
    Academic press:
    Cancer Immunology Research (rok: 2022, tom: 10(2), strony: 228-244), Wydawca: AACR
    Status:
    Published
    DOI:
    10.1158/2326-6066.CIR-20-1023 - link to the publication
  6. Monoclonal Antibodies in Dermatooncology-State of the Art and Future Perspectives.
    Authors:
    Bobrowicz M, Zagozdzon R, Domagala J, Vasconcelos-Berg R, Guenova E, Winiarska M.
    Academic press:
    Cancers (rok: 2019, tom: 11, strony: 12055), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers11101420. - link to the publication

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