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Complex effects of cannabidiol on the cardiovascular system, oxidative stress and heart metabolism in experimental models of hypertension.

2015/19/B/NZ7/02270

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia
  • NZ7_12: Prewencja chorób człowieka
  • NZ7_16: Inne zagadnienia pokrewne

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Voivodeship: podlaskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Barbara Malinowska

Number of co-investigators in the project: 18

Call

OPUS 10 – announced on 2015-09-15

Amount awarded
1 048 600 PLN
Project start date
2016-08-04
Project end date
2021-04-03
Project duration
56 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. System telemetrycznego pomiaru parametrów fizjologicznych u zwierząt. Cost: 250 000 PLN

Information in the final report

Publication in academic press/journals (6)

  1. Cannabidiol affects the Bezold-Jarisch Reflex via TRPV1 and 5-HT3 Receptors and Has Peripheral Sympathomimetic Effects in Spontaneously Hypertensive and Normotensive Rats

    Authors:
    Rafał Kossakowski, Eberhard Schlicker, Marek Toczek, Jolanta Weresa and Barbara Malinowska
    Academic press:
    Frontiers in Pharmacology (year: 2019, volume: 10, pages: 500), Publisher: Frontiers Journal Series
    Status:
    Published
    DOI:
    10.3389/fphar.2019.00500 – link to the publication

  2. Cannabinoids in arterial, pulmonary and portal hypertension - mechanisms of action and potential therapeutic significance.

    Authors:
    Malinowska B, Toczek M, Pędzińska-Betiuk A, Schlicker E.
    Academic press:
    Br J Pharmacol. 2018 (year: 2019, volume: 176, pages: 1395-1411), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1111/bph.14168 – link to the publication

  3. Chronic cannabidiol treatment reduces the carbachol-induced coronary constriction and left ventricular cardiomyocyte width of the isolated hypertensive rat heart.

    Authors:
    Anna Pędzińska-Betiuk A, Jolanta Weresa J, Eberhard Schlicker, Ewa Harasim-Symbor, Marek Toczek, Irena Kasacka, Bernadetta Gajo, Barbara Malinowska
    Academic press:
    Toxicology and Applied Pharmacology (year: 2021, volume: 411, pages: 115368), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.taap.2020.115368 – link to the publication

  4. The effects of cannabidiol, a non-intoxicating compound of cannabis, on the cardiovascular system in health and disease.

    Authors:
    Aleksandra Kicman, Marek Toczek
    Academic press:
    International Journal of Molecular Sciences (year: 2020, volume: 21, pages: 6740), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21186740 – link to the publication

  5. Chronic cannabidiol administration fails to diminish blood pressure in rats with primary and secondary hypertension despite its effects on cardiac and plasma endocannabinoid system, oxidative stress and lipid metabolism.

    Authors:
    Patryk Remiszewski, Iwona Jarocka-Karpowicz, Michał Biernacki, Anna Jastrząb, Eberhard Schlicker, Marek Toczek, Ewa Harasim-Symbor, Anna Pędzińska-Betiuk, Barbara Malinowska
    Academic press:
    International Journal of Molecular Sciences (year: 2020, volume: 21, pages: 1295), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21041295 – link to the publication

  6. Vasodilatory effects of cannabidiol in human pulmonary and rat smallmesenteric arteries: modification by hypertension and the potential pharmacological opportunities

    Authors:
    Baranowska-Kuczko M., Kozłowska H., Kloza M., Sadowska O., Kozłowski M., Kusaczuk M., Kasacka .I, Malinowska B.
    Academic press:
    Journal of Hypertension (year: 2019, volume: 37, pages: 000–000), Publisher: Wolters Kluver
    Status:
    Published
    DOI:
    10.1097/HJH.0000000000002333 – link to the publication

Articles in post-conference publications (7)

  1. Kannabidiol modyfikuje parametry stresu oksydacyjnego w sercu i osoczu szczurów z nadciśnieniem pierwotnym i wtórnym

    Authors:
    Remiszewski P., Toczek M., Biernacki M., Timoszuk A., Jastrząb A., Malinowska B.
    Conference:
    XXIV Sympozjum Sekcji Kardiologii Eksperymentalnej (year: 2019, pages: 56), Publisher: Polish Academy of Sciences & the Jagiellonian University Medical College
    Date:
    conference 2019-11-28 - 2019-11-30
    Status:
    Published

  2. Cardiovascular effects of cannabidiol in normotensive and spontaneously hypertensive rats.

    Authors:
    Malinowska B., Kossakowski R., E. Grzeda E., Weresa J., Schlicker E.
    Conference:
    84th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) (year: 2018, pages: S60), Publisher: DGPT
    Date:
    conference 26.02-01.03.2018
    Status:
    Published

  3. Influence of cannabidiol on vascular function in hypertension.

    Authors:
    Baranowska-Kuczko M., Kloza M., Kozłowska H., Toczek M., Malinowska B.
    Conference:
    8th European Workshop on cannabinoid research (year: 2017, pages: 61), Publisher: British Pharrmacological Society
    Date:
    conference 31.08-02.09.2017
    Status:
    Published

  4. Influence of chronic cannabidiol administration on cardiovascular parameters, endocannabinoid levels and oxidative stress in spontaneously hypertensive and normotensive rats.

    Authors:
    Malinowska B., Pędzińska-Betiuk A., Toczek M., Biernacki M., Timoszuk A., Jastrząb A., Weresa J., Remiszewski P.
    Conference:
    The 29th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society (year: 2019, pages: P1- 39), Publisher: International Cannabinoid Research Society
    Date:
    conference 2019-06-29 - 2019-07-04
    Status:
    Published

  5. HYPERTENSION MODIFIES THE CANNABIDIOL-MEDIATED VASCULAR RESPONSE IN ISOLATED HUMAN PULMONARY AND RAT SMALL MESENTERIC ARTERIES

    Authors:
    Olga Karpińska, Marta Baranowska-Kuczko, Monika Kloza, Mirosław Kozłowski, Hanna Kozłowska and Barbara Malinowska
    Conference:
    The 28th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society (year: 2018, pages: P1-49), Publisher: International Cannabinoid Research Society
    Date:
    conference 30.06.- 05.07.
    Status:
    Published

  6. Chronic cannabidiol treatment improves vascular function of hypertensive DOCA-salt rats in vascular bed specific manner.

    Authors:
    Baranowska–Kuczko M., Kozłowska H., Kloza M., Sadowska O., Malinowska B.
    Conference:
    The 29th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society (year: 2019, pages: P1 -7), Publisher: International Cannabinoid Research Society
    Date:
    conference 2019-06-29 - 2019-07-04
    Status:
    Published

  7. CANNABIDIOL AFFECTS THE BEZOLD-JARISCH REFLEX VIA TRPV1 AND 5-HT3 RECEPTORS AND HAS PERIPHERAL SYMPATHOMIMETIC EFFECTS IN SPONTANEOUSLY HYPERTENSIVE AND NORMOTENSIVE RATS

    Authors:
    Barbara Malinowska, Rafał Kossakowski, Jolanta Weresa, Eberhard Schlicker
    Conference:
    The 28th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society (year: 2018, pages: P1-46), Publisher: International Cannabinoid Research Society
    Date:
    conference 30.06.- 05.07.
    Status:
    Published

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