Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Functionalization of 14-membered lactone ring of Erythromycins as a source of new semisynthetic macrolide antibiotics

2015/19/B/ST5/00231

Keywords:

Chemistry of erythromycins antibiotics 14-membered lactones stereo- and regioselective reactions intramolecular interactions spectroscopy antimicrobial activity

Descriptors:

  • ST5_20:
  • ST5_16:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Piotr Przybylski 

Number of co-investigators in the project: 4

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 745 500 PLN

Project start date (Y-m-d): 2016-09-15

Project end date (Y-m-d): 2020-03-14

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Mieszadło magnetyczne (4 000 PLN)
  2. komputer z oprogramowaniem (3 500 PLN)
  3. laptop z oprogramowaniem (5 000 PLN)
  4. program do edycji widm 1D i 2D NMR (2 szt.) (10 000 PLN)
  5. Tabletkarka (5 000 PLN)
  6. waga analityczna (15 000 PLN)
  7. wyparka laboratoryjna z systemem próżniowym (35 000 PLN)
  8. kolumna do HPLC (półpreparatywna) (10 000 PLN)
  9. linia próżniowa z argonem (kompletna z butlą, pompą i kolumnami osuszającymi) (70 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (5)
  1. Cascade reactions as efficient and universal tools for construction and modification of 6-, 5-, 4- and 3-membered sulfur heterocycles of biological relevance
    Authors:
    P. Przybylski, K. Pyta-Klich, K. Pyta, A. Janas
    Academic press:
    Tetrahedron (rok: 2018, tom: 74, strony: 6335-6365), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tet.2018.09.022 - link to the publication
  2. Synthesis and antibacterial activity of new N-alkylammonium and carbonate-triazole derivatives within desosamine of 14- and 15- membered lactone macrolides
    Authors:
    A. Janas, P. Pecyna, M. Gajecka, F. Bartl, P. Przybylski*
    Academic press:
    ChemMedChem (rok: 2020, tom: 15, strony: 1529–1551), Wydawca: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
    Status:
    Published
    DOI:
    10.1002/cmdc.202000273 - link to the publication
  3. An approach to modify 14-membered lactone macrolide antibiotic scaffolds
    Authors:
    A. Janas, K. Pyta, M. Gdaniec, P. Przybylski*
    Academic press:
    The Journal of Organic Chemistry (rok: 2022, tom: x, strony: x), Wydawca: American Chemical Society
    Status:
    Accepted for publication
    DOI:
    10.1021/acs.joc.1c02799 - link to the publication
  4. 14- and 15-membered lactone macrolides and their analogues and hybrids: structure, molecular mechanism of action and biological activity
    Authors:
    A. Janas and P. Przybylski*
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 182, strony: 111662), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2019.111662 - link to the publication
  5. Synthesis, docking and antibacterial studies of more potent amine and hydrazone rifamycin congeners than rifampicin
    Authors:
    K. Pyta, A. Janas, M. Szukowska, P. Pecyna, M. Jaworska, M. Gajecka, F. Bartl, P. Przybylski
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 167, strony: 96-104), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2019.02.009 - link to the publication
  1. Modyfikacje aglikonu erytromycyny poprzez reakcje dipolarnej cykloaddycji Huisgena
    Authors:
    A. Janas, K. Pyta, P. Przybylski
    Conference:
    60 Zjazd PTCHem (rok: 2017, ), Wydawca: PTCh, European Chemical Sciences
    Data:
    konferencja 17-21 września
    Status:
    Published
  2. Synthesis, antibacterial and anticancer potency of new lactone and lactam macrolide derivatives
    Authors:
    P. Przybylski, A. Janas, K. Pyta-Klich, J. Domagalska, K. Pyta, F. Bartl
    Conference:
    2nd International Conference on Pharmaceutical Chemistry (rok: 2017, ), Wydawca: Med Chem (Los Angeles, USA)
    Data:
    konferencja 2-4 October
    Status:
    Published
  3. Synthesis, structure, antibacterial and anticancer activity of new macrolide antibiotics analogs
    Authors:
    A. Janas, K. Pyta, K. Pyta-Klich, J. Domagalska, P. Przybylski
    Conference:
    6th World Conference on physico-chemical methods in drug discovery & 3rd World conference on ADMET and DMPK (rok: 2017, ), Wydawca: Interantional Association of Physical Chemists, Ed. Zoran Mandic, Zagreb, Croatia
    Data:
    konferencja 4-7 September
    Status:
    Published
  4. Synthesis and structure-activity relationship of a new derivatives of 14- and 15-membered macrolide antibiotics containing rebuilt saccharide arms
    Authors:
    A. Janas, K. Pyta, P. Przybylski
    Conference:
    10th World Congress on Medicinal Chemistry & Drug Design (rok: 2018, ), Wydawca: Med Chem (Los Angeles, USA)
    Data:
    konferencja June 14-15, Barcelona
    Status:
    Published
  5. Synthesis and structure-activity relationship of a new derivatives of 14-, 15- and 16-membered macrolide antibiotics containing rebuilt saccharide arms
    Authors:
    Anna Janas, Krystian Pyta and Piotr Przybylski
    Conference:
    24th Conference on Isoprenoids, Białystok, Poland (rok: 2018, ), Wydawca: Bialystok University
    Data:
    konferencja September 9-12
    Status:
    Published

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