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Phosphorylation of the A/B domain as the crucial mechanism involved in substrate specificity of the two isoforms (RORgamma and RORgammaT) of the nuclear receptor RORC.

2015/19/B/NZ7/03778

Keywords:

RORgamma agonist immunotoxicity immunomodulation autoimmune disorders

Descriptors:

  • NZ7_15: Toxicology
  • NZ7_12: Prevention of human diseases
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Biologii Medycznej Polskiej Akademii Nauk

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marcin Ratajewski 

Number of co-investigators in the project: 4

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 561 132 PLN

Project start date (Y-m-d): 2016-07-18

Project end date (Y-m-d): 2019-05-17

Project duration:: 34 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. The dichotomous nature of AZ5104 (an EGFR inhibitor) towards RORγ and RORγT.
    Authors:
    Kaja Karaś, Anna Sałkowska, Iwona Karwaciak, Aurelia Walczak-Drzewiecka, Jarosław Dastych, Rafał Bachorz, and Marcin Ratajewski
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20(22), strony: 5780), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20225780 - link to the publication
  2. Digoxin, an Overlooked Agonist of RORγ/RORγT.
    Authors:
    Karaś K, Sałkowska A, Sobalska-Kwapis M, Walczak-Drzewiecka A, Strapagiel D, Dastych J, Bachorz RA, Ratajewski M.
    Academic press:
    Frontiers in Pharmacology (rok: 2019, tom: 9, strony: 1460), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fphar.2018.01460. - link to the publication
  3. The cardenolides strophanthidin, digoxigenin and dihydroouabain act as activators of the human RORγ/RORγT receptors.
    Authors:
    Karaś K, Sałkowska A, Walczak-Drzewiecka A, Ryba K, Dastych J, Bachorz RA, Ratajewski M.
    Academic press:
    Toxicology Letters (rok: 2018, tom: 295, strony: 314-324), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.toxlet.2018.07.002. - link to the publication

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