Preparation and characterisation of biocomposites based on nanoapatites for theranostic.

2015/19/B/ST5/01330

Keywords

Descriptors

  • ST5_10: Nanomateriały: nanocząstki, nanorurki
  • ST5_21: Chemia polimerów
  • NZ3_8: Komórki macierzyste

Panel

ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution

Instytut Niskich Temperatur i Badań Strukturalnych im. Włodzimierza Trzebiatowskiego PAN

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Rafał Jakub Wiglusz

Number of co-investigators in the project: 7

Call

OPUS 10 – announced on 2015-09-15

Amount awarded
1 426 200 PLN
Project start date
2016-10-28
Project end date
2021-10-27
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Hydrotermalny reaktor mikrofalowy. Cost: 3 479 PLN
  2. Mikrowytłaczarka. Cost: 384 000 PLN
  3. Nano spektrofotometr mikrolitrowy. Cost: 40 000 PLN

Information in the final report

Publication in academic press/journals (33)

  1. Lithium ions (Li+) and nanohydroxyapatite (nHAp) doped with Li+ enhance expression of late osteogenic markers in adipose-derived stem cells. Potential theranostic application of nHAp doped with Li+ and co-doped with europium (III) and samarium (III) ions

    Authors:
    M. Alicka, P. Sobierajska, K. Kornicka, R.J. Wiglusz, K. Marycz
    Academic press:
    Materials Science and Engineering C (year: 2019, volume: 99, pages: 1257-1273), Publisher: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.msec.2019.02.073 – link to the publication
  2. Effects of crystalline growth on structural and luminescence properties of Ca(10−3x)Eu2x(PO4)6F2 nanoparticles fabricated by using a microwave driven hydrothermal process

    Authors:
    Katarzyna Zawisza, Paulina Sobierajska, Guillaume Renaudin, Jean-Marie Nedelec and Rafal J. Wiglusz
    Academic press:
    CrystEngComm (year: 2017, volume: 19, pages: 6936–6949), Publisher: Royal Society of Chemistry Publishing
    Status:
    Published
    DOI:
    10.1039/C7CE01454F – link to the publication
  3. Nanomaterials Application in Orthodontics

    Authors:
    W. Zakrzewski, M. Dobrzynski, W. Dobrzynski, A. Zawadzka-Knefel, M. Janecki, K. Kurek, A. Lubojanski, M. Szymonowicz, Z. Rybak and R.J. Wiglusz
    Academic press:
    Nanomaterials (year: 2021, volume: 11, pages: 337), Publisher: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano11020337 – link to the publication
  4. New approach to modification of poly (L-lactic acid) with nanohydroxyapatite improving functionality of human adipose-derived stromal cells (hASCs) through increased viability and enhanced mitochondrial activity

    Authors:
    Agnieszka Smieszeka, Krzysztof Marycz, Konrad Szustakiewicz, Bartłomiej Kryszak, Sara Targonska, Katarzyna Zawisza, Adam Watras, Rafal J. Wiglusz
    Academic press:
    Materials Science and Engineering C (year: 2019, volume: 98, pages: 213–226), Publisher: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.msec.2018.12.099 – link to the publication
  5. The influence of hydroxyapatite content on properties of poly(L-lactide)/hydroxyapatite porous scaffolds obtained using thermal induced phase separation technique

    Authors:
    Konrad Szustakiewicz, Małgorzata Gazińska, Bartłomiej Kryszaka, Michał Grzymajło, Jacek Pigłowski, Rafał J. Wiglusz, Masami Okamoto
    Academic press:
    European Polymer Journal (year: 2019, volume: 113, pages: 313–320), Publisher: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.eurpolymj.2019.01.073 – link to the publication
  6. Influence of the grain sizes on Stokes and anti-Stokes fluorescence in the Yb3þ and Tb3þ ions co-doped nanocrystalline fluorapatite

    Authors:
    Paulina Sobierajska, Rafal J. Wiglusz
    Academic press:
    Journal of Alloys and Compounds (year: 2019, volume: 785, pages: 808-818), Publisher: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.jallcom.2019.01.146 – link to the publication
  7. Nanocrystalline Hydroxyapatite Loaded with Resveratrol in Colloidal Suspension Improves Viability, Metabolic Activity and Mitochondrial Potential in Human Adipose-Derived Mesenchymal Stromal Stem Cells (hASCs)

    Authors:
    Krzysztof Marycz, Agnieszka Smieszek, Justyna Trynda, Paulina Sobierajska, Sara Targonska, Lukasz Grosman and Rafal J. Wiglusz
    Academic press:
    Polymers - Open Access Journal (year: 2019, volume: 11(1), pages: 46045), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/polym11010092 – link to the publication
  8. Preparation and antimicrobial activity of the porous hydroxyapatite nanoceramics

    Authors:
    Paulina Sobierajska, Agata Dorotkiewicz-Jach, Katarzyna Zawisza, Janina Okal, Tomasz Olszak, Zuzanna Drulis-Kawa, Rafal J. Wiglusz
    Academic press:
    Journal of Alloys and Compounds (year: 2018, volume: 748, pages: 179 - 187), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jallcom.2018.03.162 – link to the publication
  9. Influence of surface modifications of nanostructured scaffold on osseointegration capacity - preliminary in vivo study

    Authors:
    Maciej Janeczek, Patrycja Szymczyk, Maciej Dobrzynski, Olga Parulska, Maria Szymonowicz, Piotr Kuropka, Zbigniew Rybak, Boguslawa Zywicka, Grzegorz Ziolkowski, Krzysztof Marycz, Aleksander Chroszcz, Aleksandra Skalec, Sara Targonska and Rafal J. Wiglusz
    Academic press:
    RSC Advances (year: 2018, volume: 8, pages: 15533-15546), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c8ra01625a – link to the publication
  10. Multifunctionality of Nanosized Calcium Apatite Dual-Doped with Li+/Eu3+ Ions Related to Cell Culture Studies and Cytotoxicity Evaluation In Vitro

    Authors:
    P. Sobierajska, B. Pozniak, M. Tikhomirov, J. Miller, L. Mrowczynska, A. Piecuch, J. Rewak-Soroczynska, Agata Dorotkiewicz-Jach, Zuzanna Drulis-Kawa and R.J. Wiglusz
    Academic press:
    Biomolecules (year: 2021, volume: 11, pages: 1388), Publisher: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/biom11091388 – link to the publication
  11. New Approach to Antifungal Activity of Fluconazole Incorporated into the Porous 6-Anhydro- α-L-Galacto-β-D-Galactan Structures Modified with Nanohydroxyapatite for Chronic-Wound Treatments - In Vitro Evaluation

    Authors:
    J. Rewak-Soroczynska, P. Sobierajska, S. Targonska, A. Piecuch, L. Grosman, J. Rachuna, S. Wasik, M. Arabski, R. Ogorek and R.J. Wiglusz
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 3112), Publisher: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/ijms22063112 – link to the publication
  12. Three dimensional (3D) printed polylactic acid with nano-hydroxyapatite doped with europium(III) ions (nHAp/PLLA@Eu3+) composite for osteochondral defect regeneration and theranostics

    Authors:
    K. Marycz, A. Smieszeka, S. Targonska, S.A. Walsh, K. Szustakiewicz, R.J. Wiglusz
    Academic press:
    Materials Science & Engineering C (year: 2020, volume: 110, pages: 110634), Publisher: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.msec.2020.110634 – link to the publication
  13. Preparation of a New Biocomposite Designed for Cartilage Grafting with Antibiofilm Activity

    Authors:
    S. Targonska, J. Rewak-Soroczynska, A. Piecuch, E. Paluch, D. Szymanski, and R.J. Wiglusz
    Academic press:
    ACS Omega (year: 2020, volume: 5, pages: 24546-24557), Publisher: American Chemical Society Publications
    Status:
    Published
    DOI:
    10.1021/acsomega.0c03044 – link to the publication
  14. Structural modification of nanohydroxyapatite Ca10(PO4)6(OH)2 related to Eu3+ and Sr2+ ions doping and its spectroscopic and antimicrobial properties

    Authors:
    Katarzyna Szyszka, Justyna Rewak-Soroczynska, Agata Dorotkiewicz-Jach, Karolina A. Ledwa, Agata Piecuch, Michael Giersig, Zuzanna Drulis-Kawa, Rafal J. Wiglusz
    Academic press:
    Journal of Inorganic Biochemistry (year: 2020, volume: 203, pages: 110884), Publisher: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2019.110884 – link to the publication
  15. Assessment of Microstructure and Release of Fluoride Ions from Selected Fissure Sealants: An In Vitro Study

    Authors:
    K. Fita, M. Dobrzyński, M. Ziętek, D. Diakowska, A. Watras and R.J. Wiglusz
    Academic press:
    Materials (year: 2021, volume: 14, pages: 4936), Publisher: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/ma14174936 – link to the publication
  16. In Vitro Studies concerning Selected Properties of a Composite Material Blended with Nanofluoroapatite Crystals

    Authors:
    M. Zietek, M. Dobrzynski, K. Fita, D. Diakowska, A. Watras and R.J. Wiglusz
    Academic press:
    Materials (year: 2021, volume: 14, pages: 7295), Publisher: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/ma14237295 – link to the publication
  17. Preparation and Characterization of Self-Assembled Poly(l-Lactide) on the Surface of β-Tricalcium Diphosphate(V) for Bone Tissue Theranostics

    Authors:
    J.A. Zienkiewicz, A. Strzep, D. Jedrzkiewicz, N. Nowak, J. Rewak-Soroczynska, A. Watras, J. Ejfler and R.J. Wiglusz
    Academic press:
    Nanomaterials — Open Access Journal (year: 2020, volume: 10, pages: 331), Publisher: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano10020331 – link to the publication
  18. Application of Selected Nanomaterials and Ozone in Modern Clinical Dentistry

    Authors:
    A. Lubojanski, M. Dobrzynski, N. Nowak, J. Rewak-Soroczynska, K. Sztyler, W. Zakrzewski, W. Dobrzynski, M. Szymonowicz, Z. Rybak, K. Wiglusz and R.J. Wiglusz
    Academic press:
    Nanomaterials (year: 2021, volume: 11, pages: 259), Publisher: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano11020259 – link to the publication
  19. The Influence of Ozonated Olive Oil-Loaded and Copper-Doped Nanohydroxyapatites on Planktonic Forms of Microorganisms

    Authors:
    W. Zakrzewski, M. Dobrzynski, J. Nowicka, M. Pajaczkowska, M. Szymonowicz, S. Targonska, P. Sobierajska, K. Wiglusz, W. Dobrzynski, A. Lubojanski, S. Fedorowicz, Z. Rybak and R.J. Wiglusz
    Academic press:
    Nanomaterials — Open Access Journal (year: 2020, volume: 10, pages: 1997), Publisher: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano10101997 – link to the publication
  20. The Influence of a Knitted Hydrophilic Prosthesis of Blood Vessels on the Activation of Coagulation System - In Vitro Study

    Authors:
    M. Szymonowicz, M. Dobrzynski, S. Targonska, A. Rusak, Z. Rybak, M.H. Struszczyk, J. Majda, D. Szymanski and R.J. Wiglusz
    Academic press:
    Nanomaterials (year: 2021, volume: 11, pages: 1600), Publisher: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano11061600 – link to the publication
  21. Nanostructural Materials with Rare Earth Ions: Synthesis, Physicochemical Characterization, Modification and Applications

    Authors:
    R.J. Wiglusz
    Academic press:
    Nanomaterials (year: 2021, volume: 11, pages: 1848), Publisher: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano11071848 – link to the publication
  22. Quenching of the Eu3+ Luminescence by Cu2+ Ions in the Nanosized Hydroxyapatite Designed for Future Bio-Detection

    Authors:
    K. Szyszka, S. Targońska, A. Lewińska, A. Watras and R.J. Wiglusz
    Academic press:
    Nanomaterials (year: 2021, volume: 11, pages: 464), Publisher: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano11020464 – link to the publication
  23. Selected Nanomaterials' Application Enhanced with the Use of Stem Cells in Acceleration of Alveolar Bone Regeneration during Augmentation Process

    Authors:
    W. Zakrzewski, M. Dobrzynski , Z. Rybak, M. Szymonowicz and R.J. Wiglusz
    Academic press:
    Nanomaterials — Open Access Journal (year: 2020, volume: 10, pages: 1216), Publisher: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano10061216 – link to the publication
  24. Theranostic Applications of Nanostructured Silicate-Substituted Hydroxyapatite Codoped with Eu3+ and Bi3+ Ions - A Novel Strategy for Bone Regeneration

    Authors:
    S. Targonska, M. Sikora, K. Marycz, A. Smieszek, and R.J. Wiglusz
    Academic press:
    ACS Biomaterials Science & Engineering (year: 2020, volume: 6, pages: 6148-6160), Publisher: American Chemical Society Publications
    Status:
    Published
    DOI:
    10.1021/acsbiomaterials.0c00824 – link to the publication
  25. Investigation of Physicochemical Properties of the Structurally Modified Nanosized Silicate-Substituted Hydroxyapatite Co-Doped with Eu3+ and Sr2+ Ions

    Authors:
    S. Targonska and R.J. Wiglusz
    Academic press:
    Nanomaterials (year: 2021, volume: 11, pages: 27), Publisher: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano11010027 – link to the publication
  26. Investigation of Pyrophosphates KYP2O7Co-Doped with Lanthanide Ions Useful for Theranostics

    Authors:
    Adam Watras, Marta Wujczyk, Michael Roecken, Katarzyna Kucharczyk, Krzysztof Marycz and Rafal J. Wiglusz
    Academic press:
    Nanomaterials — Open Access Journal (year: 2019, volume: 9, pages: 1597-1614), Publisher: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano9111597 – link to the publication
  27. The Potential Selective Cytotoxicity of Poly(L-Lactic Acid)-Based Scaffolds Functionalized with Nanohydroxyapatite and Europium (III) Ions toward Osteosarcoma Cells

    Authors:
    Mateusz Sikora, Klaudia Marcinkowska, Krzysztof Marycz, Rafał Jakub Wiglusz and Agnieszka Śmieszek
    Academic press:
    Materials— Open Access Journal (year: 2019, volume: 12, pages: 3779-3799), Publisher: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/ma12223779 – link to the publication
  28. Nanohydroxyapatite as a Biomaterial for Peripheral Nerve Regeneration after Mechanical Damage - In Vitro Study

    Authors:
    B. Wiatrak, P. Sobierajska, M. Szandruk-Bender, P. Jawien, M. Janeczek, M. Dobrzynski, P. Pistor, A. Szelag and R.J. Wiglusz
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 4454), Publisher: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/ijms22094454 – link to the publication
  29. The Comprehensive Approach to Preparation and Investigation of the Eu3+ Doped Hydroxyapatite/poly(L-lactide) Nanocomposites: Promising Materials for Theranostics Application

    Authors:
    Katarzyna Szyszka, Sara Targonska, Malgorzata Gazinska, Konrad Szustakiewicz and Rafal J.Wiglusz
    Academic press:
    Nanomaterials — Open Access Journal (year: 2019, volume: 9, pages: 1146-1162), Publisher: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano9081146 – link to the publication
  30. A new approach to spectroscopic and structural studies of the nano-sized silicate-substituted hydroxyapatite doped with Eu3+ ions

    Authors:
    S. Targonska, K. Szyszka, J. Rewak-Soroczynska and R. J. Wiglusz
    Academic press:
    Dalton Transactions (year: 2019, volume: 48, pages: 8303–8316), Publisher: Royal Society of Chemistry Publishing
    Status:
    Published
    DOI:
    10.1039/C9DT01025D – link to the publication
  31. Preparation and preliminary evaluation of bio-nanocomposites based on hydroxyapatites with antibacterial properties against anaerobic bacteria

    Authors:
    Katarzyna Zawisza, Paulina Sobierajska, Nicole Nowak, Anna Kedziora, Kamila Korzekwa, Blazej Pozniak, Marta Tikhomirov, Julia Miller, Lucyna Mrowczynska, Rafal J. Wiglusz
    Academic press:
    Materials Science and Engineering C (year: 2020, volume: 106, pages: 110295), Publisher: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.msec.2019.110295 – link to the publication
  32. Preliminary In Vitro Study of Fluoride Release from Selected Ormocer Materials

    Authors:
    P. Kosior, M. Dobrzynski, A. Zakrzewska, L. Grosman, M. Korczynski, T. Blicharski, M. Gutbier, A. Watras and R.J. Wiglusz
    Academic press:
    Materials (year: 2021, volume: 14, pages: 2244), Publisher: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/ma14092244 – link to the publication
  33. In Vitro Assessment of Long-Term Fluoride Ion Release from Nanofluorapatite

    Authors:
    K. Herman, M. Wujczyk, M. Dobrzynski, D. Diakowska, K. Wiglusz and R.J. Wiglusz
    Academic press:
    Materials (year: 2021, volume: 14, pages: 3747), Publisher: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/ma14133747 – link to the publication

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Graphic design and implementation: Jakub Piotrowski