Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Preparation and characterisation of biocomposites based on nanoapatites for theranostic.

2015/19/B/ST5/01330

Keywords:

Biocomposite Nanoapatite Tissue regeneration

Descriptors:

  • ST5_10: Functional materials/nanomaterials, nanoparticles
  • ST5_21:
  • NZ3_8: Stem cell biology

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Niskich Temperatur i Badań Strukturalnych im. Włodzimierza Trzebiatowskiego Polskiej Akademii Nauk

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Rafał Wiglusz 

Number of co-investigators in the project: 7

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 1 426 200 PLN

Project start date (Y-m-d): 2016-10-28

Project end date (Y-m-d): 2021-10-27

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Mikrowytłaczarka (384 000 PLN)
  2. Hydrotermalny reaktor mikrofalowy (3 479 PLN)
  3. Nano spektrofotometr mikrolitrowy (40 000 PLN)

Information in the final report

  • Publication in academic press/journals (33)
  1. A new approach to spectroscopic and structural studies of the nano-sized silicate-substituted hydroxyapatite doped with Eu3+ ions
    Authors:
    S. Targonska, K. Szyszka, J. Rewak-Soroczynska and R. J. Wiglusz
    Academic press:
    Dalton Transactions (rok: 2019, tom: 48, strony: 8303–8316), Wydawca: Royal Society of Chemistry Publishing
    Status:
    Published
    DOI:
    10.1039/C9DT01025D - link to the publication
  2. Nanocrystalline Hydroxyapatite Loaded with Resveratrol in Colloidal Suspension Improves Viability, Metabolic Activity and Mitochondrial Potential in Human Adipose-Derived Mesenchymal Stromal Stem Cells (hASCs)
    Authors:
    Krzysztof Marycz, Agnieszka Smieszek, Justyna Trynda, Paulina Sobierajska, Sara Targonska, Lukasz Grosman and Rafal J. Wiglusz
    Academic press:
    Polymers - Open Access Journal (rok: 2019, tom: 11(1), strony: 45314), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/polym11010092 - link to the publication
  3. Preparation and Characterization of Self-Assembled Poly(l-Lactide) on the Surface of β-Tricalcium Diphosphate(V) for Bone Tissue Theranostics
    Authors:
    J.A. Zienkiewicz, A. Strzep, D. Jedrzkiewicz, N. Nowak, J. Rewak-Soroczynska, A. Watras, J. Ejfler and R.J. Wiglusz
    Academic press:
    Nanomaterials — Open Access Journal (rok: 2020, tom: 10, strony: 331), Wydawca: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano10020331 - link to the publication
  4. Preparation and antimicrobial activity of the porous hydroxyapatite nanoceramics
    Authors:
    Paulina Sobierajska, Agata Dorotkiewicz-Jach, Katarzyna Zawisza, Janina Okal, Tomasz Olszak, Zuzanna Drulis-Kawa, Rafal J. Wiglusz
    Academic press:
    Journal of Alloys and Compounds (rok: 2018, tom: 748, strony: 179 - 187), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jallcom.2018.03.162 - link to the publication
  5. The Comprehensive Approach to Preparation and Investigation of the Eu3+ Doped Hydroxyapatite/poly(L-lactide) Nanocomposites: Promising Materials for Theranostics Application
    Authors:
    Katarzyna Szyszka, Sara Targonska, Malgorzata Gazinska, Konrad Szustakiewicz and Rafal J.Wiglusz
    Academic press:
    Nanomaterials — Open Access Journal (rok: 2019, tom: 9, strony: 1146-1162), Wydawca: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano9081146 - link to the publication
  6. The influence of hydroxyapatite content on properties of poly(L-lactide)/hydroxyapatite porous scaffolds obtained using thermal induced phase separation technique
    Authors:
    Konrad Szustakiewicz, Małgorzata Gazińska, Bartłomiej Kryszaka, Michał Grzymajło, Jacek Pigłowski, Rafał J. Wiglusz, Masami Okamoto
    Academic press:
    European Polymer Journal (rok: 2019, tom: 113, strony: 313–320), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.eurpolymj.2019.01.073 - link to the publication
  7. Theranostic Applications of Nanostructured Silicate-Substituted Hydroxyapatite Codoped with Eu3+ and Bi3+ Ions - A Novel Strategy for Bone Regeneration
    Authors:
    S. Targonska, M. Sikora, K. Marycz, A. Smieszek, and R.J. Wiglusz
    Academic press:
    ACS Biomaterials Science & Engineering (rok: 2020, tom: 6, strony: 6148-6160), Wydawca: American Chemical Society Publications
    Status:
    Published
    DOI:
    10.1021/acsbiomaterials.0c00824 - link to the publication
  8. Application of Selected Nanomaterials and Ozone in Modern Clinical Dentistry
    Authors:
    A. Lubojanski, M. Dobrzynski, N. Nowak, J. Rewak-Soroczynska, K. Sztyler, W. Zakrzewski, W. Dobrzynski, M. Szymonowicz, Z. Rybak, K. Wiglusz and R.J. Wiglusz
    Academic press:
    Nanomaterials (rok: 2021, tom: 11, strony: 259), Wydawca: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano11020259 - link to the publication
  9. Effects of crystalline growth on structural and luminescence properties of Ca(10−3x)Eu2x(PO4)6F2 nanoparticles fabricated by using a microwave driven hydrothermal process
    Authors:
    Katarzyna Zawisza, Paulina Sobierajska, Guillaume Renaudin, Jean-Marie Nedelec and Rafal J. Wiglusz
    Academic press:
    CrystEngComm (rok: 2017, tom: 19, strony: 6936–6949), Wydawca: Royal Society of Chemistry Publishing
    Status:
    Published
    DOI:
    10.1039/C7CE01454F - link to the publication
  10. Influence of the grain sizes on Stokes and anti-Stokes fluorescence in the Yb3þ and Tb3þ ions co-doped nanocrystalline fluorapatite
    Authors:
    Paulina Sobierajska, Rafal J. Wiglusz
    Academic press:
    Journal of Alloys and Compounds (rok: 2019, tom: 785, strony: 808-818), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.jallcom.2019.01.146 - link to the publication
  11. Lithium ions (Li+) and nanohydroxyapatite (nHAp) doped with Li+ enhance expression of late osteogenic markers in adipose-derived stem cells. Potential theranostic application of nHAp doped with Li+ and co-doped with europium (III) and samarium (III) ions
    Authors:
    M. Alicka, P. Sobierajska, K. Kornicka, R.J. Wiglusz, K. Marycz
    Academic press:
    Materials Science and Engineering C (rok: 2019, tom: 99, strony: 1257-1273), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.msec.2019.02.073 - link to the publication
  12. Nanostructural Materials with Rare Earth Ions: Synthesis, Physicochemical Characterization, Modification and Applications
    Authors:
    R.J. Wiglusz
    Academic press:
    Nanomaterials (rok: 2021, tom: 11, strony: 1848), Wydawca: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano11071848 - link to the publication
  13. Structural modification of nanohydroxyapatite Ca10(PO4)6(OH)2 related to Eu3+ and Sr2+ ions doping and its spectroscopic and antimicrobial properties
    Authors:
    Katarzyna Szyszka, Justyna Rewak-Soroczynska, Agata Dorotkiewicz-Jach, Karolina A. Ledwa, Agata Piecuch, Michael Giersig, Zuzanna Drulis-Kawa, Rafal J. Wiglusz
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2020, tom: 203, strony: 110884), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2019.110884 - link to the publication
  14. The Potential Selective Cytotoxicity of Poly(L-Lactic Acid)-Based Scaffolds Functionalized with Nanohydroxyapatite and Europium (III) Ions toward Osteosarcoma Cells
    Authors:
    Mateusz Sikora, Klaudia Marcinkowska, Krzysztof Marycz, Rafał Jakub Wiglusz and Agnieszka Śmieszek
    Academic press:
    Materials— Open Access Journal (rok: 2019, tom: 12, strony: 3779-3799), Wydawca: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/ma12223779 - link to the publication
  15. In Vitro Studies concerning Selected Properties of a Composite Material Blended with Nanofluoroapatite Crystals
    Authors:
    M. Zietek, M. Dobrzynski, K. Fita, D. Diakowska, A. Watras and R.J. Wiglusz
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 7295), Wydawca: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/ma14237295 - link to the publication
  16. New Approach to Antifungal Activity of Fluconazole Incorporated into the Porous 6-Anhydro- α-L-Galacto-β-D-Galactan Structures Modified with Nanohydroxyapatite for Chronic-Wound Treatments - In Vitro Evaluation
    Authors:
    J. Rewak-Soroczynska, P. Sobierajska, S. Targonska, A. Piecuch, L. Grosman, J. Rachuna, S. Wasik, M. Arabski, R. Ogorek and R.J. Wiglusz
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 3112), Wydawca: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/ijms22063112 - link to the publication
  17. Preliminary In Vitro Study of Fluoride Release from Selected Ormocer Materials
    Authors:
    P. Kosior, M. Dobrzynski, A. Zakrzewska, L. Grosman, M. Korczynski, T. Blicharski, M. Gutbier, A. Watras and R.J. Wiglusz
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 2244), Wydawca: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/ma14092244 - link to the publication
  18. Quenching of the Eu3+ Luminescence by Cu2+ Ions in the Nanosized Hydroxyapatite Designed for Future Bio-Detection
    Authors:
    K. Szyszka, S. Targońska, A. Lewińska, A. Watras and R.J. Wiglusz
    Academic press:
    Nanomaterials (rok: 2021, tom: 11, strony: 464), Wydawca: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano11020464 - link to the publication
  19. Three dimensional (3D) printed polylactic acid with nano-hydroxyapatite doped with europium(III) ions (nHAp/PLLA@Eu3+) composite for osteochondral defect regeneration and theranostics
    Authors:
    K. Marycz, A. Smieszeka, S. Targonska, S.A. Walsh, K. Szustakiewicz, R.J. Wiglusz
    Academic press:
    Materials Science & Engineering C (rok: 2020, tom: 110, strony: 110634), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.msec.2020.110634 - link to the publication
  20. Investigation of Physicochemical Properties of the Structurally Modified Nanosized Silicate-Substituted Hydroxyapatite Co-Doped with Eu3+ and Sr2+ Ions
    Authors:
    S. Targonska and R.J. Wiglusz
    Academic press:
    Nanomaterials (rok: 2021, tom: 11, strony: 27), Wydawca: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano11010027 - link to the publication
  21. Multifunctionality of Nanosized Calcium Apatite Dual-Doped with Li+/Eu3+ Ions Related to Cell Culture Studies and Cytotoxicity Evaluation In Vitro
    Authors:
    P. Sobierajska, B. Pozniak, M. Tikhomirov, J. Miller, L. Mrowczynska, A. Piecuch, J. Rewak-Soroczynska, Agata Dorotkiewicz-Jach, Zuzanna Drulis-Kawa and R.J. Wiglusz
    Academic press:
    Biomolecules (rok: 2021, tom: 11, strony: 1388), Wydawca: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/biom11091388 - link to the publication
  22. Nanohydroxyapatite as a Biomaterial for Peripheral Nerve Regeneration after Mechanical Damage - In Vitro Study
    Authors:
    B. Wiatrak, P. Sobierajska, M. Szandruk-Bender, P. Jawien, M. Janeczek, M. Dobrzynski, P. Pistor, A. Szelag and R.J. Wiglusz
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 4454), Wydawca: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/ijms22094454 - link to the publication
  23. Nanomaterials Application in Orthodontics
    Authors:
    W. Zakrzewski, M. Dobrzynski, W. Dobrzynski, A. Zawadzka-Knefel, M. Janecki, K. Kurek, A. Lubojanski, M. Szymonowicz, Z. Rybak and R.J. Wiglusz
    Academic press:
    Nanomaterials (rok: 2021, tom: 11, strony: 337), Wydawca: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano11020337 - link to the publication
  24. New approach to modification of poly (L-lactic acid) with nanohydroxyapatite improving functionality of human adipose-derived stromal cells (hASCs) through increased viability and enhanced mitochondrial activity
    Authors:
    Agnieszka Smieszeka, Krzysztof Marycz, Konrad Szustakiewicz, Bartłomiej Kryszak, Sara Targonska, Katarzyna Zawisza, Adam Watras, Rafal J. Wiglusz
    Academic press:
    Materials Science and Engineering C (rok: 2019, tom: 98, strony: 213–226), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.msec.2018.12.099 - link to the publication
  25. Preparation and preliminary evaluation of bio-nanocomposites based on hydroxyapatites with antibacterial properties against anaerobic bacteria
    Authors:
    Katarzyna Zawisza, Paulina Sobierajska, Nicole Nowak, Anna Kedziora, Kamila Korzekwa, Blazej Pozniak, Marta Tikhomirov, Julia Miller, Lucyna Mrowczynska, Rafal J. Wiglusz
    Academic press:
    Materials Science and Engineering C (rok: 2020, tom: 106, strony: 110295), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.msec.2019.110295 - link to the publication
  26. The Influence of Ozonated Olive Oil-Loaded and Copper-Doped Nanohydroxyapatites on Planktonic Forms of Microorganisms
    Authors:
    W. Zakrzewski, M. Dobrzynski, J. Nowicka, M. Pajaczkowska, M. Szymonowicz, S. Targonska, P. Sobierajska, K. Wiglusz, W. Dobrzynski, A. Lubojanski, S. Fedorowicz, Z. Rybak and R.J. Wiglusz
    Academic press:
    Nanomaterials — Open Access Journal (rok: 2020, tom: 10, strony: 1997), Wydawca: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano10101997 - link to the publication
  27. Assessment of Microstructure and Release of Fluoride Ions from Selected Fissure Sealants: An In Vitro Study
    Authors:
    K. Fita, M. Dobrzyński, M. Ziętek, D. Diakowska, A. Watras and R.J. Wiglusz
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 4936), Wydawca: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/ma14174936 - link to the publication
  28. In Vitro Assessment of Long-Term Fluoride Ion Release from Nanofluorapatite
    Authors:
    K. Herman, M. Wujczyk, M. Dobrzynski, D. Diakowska, K. Wiglusz and R.J. Wiglusz
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 3747), Wydawca: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/ma14133747 - link to the publication
  29. Influence of surface modifications of nanostructured scaffold on osseointegration capacity - preliminary in vivo study
    Authors:
    Maciej Janeczek, Patrycja Szymczyk, Maciej Dobrzynski, Olga Parulska, Maria Szymonowicz, Piotr Kuropka, Zbigniew Rybak, Boguslawa Zywicka, Grzegorz Ziolkowski, Krzysztof Marycz, Aleksander Chroszcz, Aleksandra Skalec, Sara Targonska and Rafal J. Wiglusz
    Academic press:
    RSC Advances (rok: 2018, tom: 8, strony: 15533-15546), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c8ra01625a - link to the publication
  30. Investigation of Pyrophosphates KYP2O7Co-Doped with Lanthanide Ions Useful for Theranostics
    Authors:
    Adam Watras, Marta Wujczyk, Michael Roecken, Katarzyna Kucharczyk, Krzysztof Marycz and Rafal J. Wiglusz
    Academic press:
    Nanomaterials — Open Access Journal (rok: 2019, tom: 9, strony: 1597-1614), Wydawca: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano9111597 - link to the publication
  31. Preparation of a New Biocomposite Designed for Cartilage Grafting with Antibiofilm Activity
    Authors:
    S. Targonska, J. Rewak-Soroczynska, A. Piecuch, E. Paluch, D. Szymanski, and R.J. Wiglusz
    Academic press:
    ACS Omega (rok: 2020, tom: 5, strony: 24546-24557), Wydawca: American Chemical Society Publications
    Status:
    Published
    DOI:
    10.1021/acsomega.0c03044 - link to the publication
  32. Selected Nanomaterials' Application Enhanced with the Use of Stem Cells in Acceleration of Alveolar Bone Regeneration during Augmentation Process
    Authors:
    W. Zakrzewski, M. Dobrzynski , Z. Rybak, M. Szymonowicz and R.J. Wiglusz
    Academic press:
    Nanomaterials — Open Access Journal (rok: 2020, tom: 10, strony: 1216), Wydawca: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano10061216 - link to the publication
  33. The Influence of a Knitted Hydrophilic Prosthesis of Blood Vessels on the Activation of Coagulation System - In Vitro Study
    Authors:
    M. Szymonowicz, M. Dobrzynski, S. Targonska, A. Rusak, Z. Rybak, M.H. Struszczyk, J. Majda, D. Szymanski and R.J. Wiglusz
    Academic press:
    Nanomaterials (rok: 2021, tom: 11, strony: 1600), Wydawca: MDPI Publisher of Open Access Journals
    Status:
    Published
    DOI:
    10.3390/nano11061600 - link to the publication

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