Preparation and characterisation of biocomposites based on nanoapatites for theranostic.
2015/19/B/ST5/01330
Keywords
Descriptors
- ST5_10: Nanomateriały: nanocząstki, nanorurki
- ST5_21: Chemia polimerów
- NZ3_8: Komórki macierzyste
Panel
ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution
Instytut Niskich Temperatur i Badań Strukturalnych im. Włodzimierza Trzebiatowskiego PAN
Voivodeship: dolnośląskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 7
Call
OPUS 10 – announced on 2015-09-15
- Amount awarded
- 1 426 200 PLN
- Project start date
- 2016-10-28
- Project end date
- 2021-10-27
- Project duration
- 60 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Hydrotermalny reaktor mikrofalowy. Cost: 3 479 PLN
- Mikrowytłaczarka. Cost: 384 000 PLN
- Nano spektrofotometr mikrolitrowy. Cost: 40 000 PLN
Information in the final report
Publication in academic press/journals (33)
-
Lithium ions (Li+) and nanohydroxyapatite (nHAp) doped with Li+ enhance expression of late osteogenic markers in adipose-derived stem cells. Potential theranostic application of nHAp doped with Li+ and co-doped with europium (III) and samarium (III) ions
- Authors:
- M. Alicka, P. Sobierajska, K. Kornicka, R.J. Wiglusz, K. Marycz
- Academic press:
- Materials Science and Engineering C (year: 2019, volume: 99, pages: 1257-1273), Publisher: Elsevier B.V.
- Status:
- Published
- DOI:
- 10.1016/j.msec.2019.02.073 – link to the publication
-
Effects of crystalline growth on structural and luminescence properties of Ca(10−3x)Eu2x(PO4)6F2 nanoparticles fabricated by using a microwave driven hydrothermal process
- Authors:
- Katarzyna Zawisza, Paulina Sobierajska, Guillaume Renaudin, Jean-Marie Nedelec and Rafal J. Wiglusz
- Academic press:
- CrystEngComm (year: 2017, volume: 19, pages: 6936–6949), Publisher: Royal Society of Chemistry Publishing
- Status:
- Published
- DOI:
- 10.1039/C7CE01454F – link to the publication
-
Nanomaterials Application in Orthodontics
- Authors:
- W. Zakrzewski, M. Dobrzynski, W. Dobrzynski, A. Zawadzka-Knefel, M. Janecki, K. Kurek, A. Lubojanski, M. Szymonowicz, Z. Rybak and R.J. Wiglusz
- Academic press:
- Nanomaterials (year: 2021, volume: 11, pages: 337), Publisher: MDPI Publisher of Open Access Journals
- Status:
- Published
- DOI:
- 10.3390/nano11020337 – link to the publication
-
New approach to modification of poly (L-lactic acid) with nanohydroxyapatite improving functionality of human adipose-derived stromal cells (hASCs) through increased viability and enhanced mitochondrial activity
- Authors:
- Agnieszka Smieszeka, Krzysztof Marycz, Konrad Szustakiewicz, Bartłomiej Kryszak, Sara Targonska, Katarzyna Zawisza, Adam Watras, Rafal J. Wiglusz
- Academic press:
- Materials Science and Engineering C (year: 2019, volume: 98, pages: 213–226), Publisher: Elsevier B.V.
- Status:
- Published
- DOI:
- 10.1016/j.msec.2018.12.099 – link to the publication
-
The influence of hydroxyapatite content on properties of poly(L-lactide)/hydroxyapatite porous scaffolds obtained using thermal induced phase separation technique
- Authors:
- Konrad Szustakiewicz, Małgorzata Gazińska, Bartłomiej Kryszaka, Michał Grzymajło, Jacek Pigłowski, Rafał J. Wiglusz, Masami Okamoto
- Academic press:
- European Polymer Journal (year: 2019, volume: 113, pages: 313–320), Publisher: Elsevier B.V.
- Status:
- Published
- DOI:
- 10.1016/j.eurpolymj.2019.01.073 – link to the publication
-
Influence of the grain sizes on Stokes and anti-Stokes fluorescence in the Yb3þ and Tb3þ ions co-doped nanocrystalline fluorapatite
- Authors:
- Paulina Sobierajska, Rafal J. Wiglusz
- Academic press:
- Journal of Alloys and Compounds (year: 2019, volume: 785, pages: 808-818), Publisher: Elsevier B.V.
- Status:
- Published
- DOI:
- 10.1016/j.jallcom.2019.01.146 – link to the publication
-
Nanocrystalline Hydroxyapatite Loaded with Resveratrol in Colloidal Suspension Improves Viability, Metabolic Activity and Mitochondrial Potential in Human Adipose-Derived Mesenchymal Stromal Stem Cells (hASCs)
- Authors:
- Krzysztof Marycz, Agnieszka Smieszek, Justyna Trynda, Paulina Sobierajska, Sara Targonska, Lukasz Grosman and Rafal J. Wiglusz
- Academic press:
- Polymers - Open Access Journal (year: 2019, volume: 11(1), pages: 46045), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/polym11010092 – link to the publication
-
Preparation and antimicrobial activity of the porous hydroxyapatite nanoceramics
- Authors:
- Paulina Sobierajska, Agata Dorotkiewicz-Jach, Katarzyna Zawisza, Janina Okal, Tomasz Olszak, Zuzanna Drulis-Kawa, Rafal J. Wiglusz
- Academic press:
- Journal of Alloys and Compounds (year: 2018, volume: 748, pages: 179 - 187), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.jallcom.2018.03.162 – link to the publication
-
Influence of surface modifications of nanostructured scaffold on osseointegration capacity - preliminary in vivo study
- Authors:
- Maciej Janeczek, Patrycja Szymczyk, Maciej Dobrzynski, Olga Parulska, Maria Szymonowicz, Piotr Kuropka, Zbigniew Rybak, Boguslawa Zywicka, Grzegorz Ziolkowski, Krzysztof Marycz, Aleksander Chroszcz, Aleksandra Skalec, Sara Targonska and Rafal J. Wiglusz
- Academic press:
- RSC Advances (year: 2018, volume: 8, pages: 15533-15546), Publisher: Royal Society of Chemistry
- Status:
- Published
- DOI:
- 10.1039/c8ra01625a – link to the publication
-
Multifunctionality of Nanosized Calcium Apatite Dual-Doped with Li+/Eu3+ Ions Related to Cell Culture Studies and Cytotoxicity Evaluation In Vitro
- Authors:
- P. Sobierajska, B. Pozniak, M. Tikhomirov, J. Miller, L. Mrowczynska, A. Piecuch, J. Rewak-Soroczynska, Agata Dorotkiewicz-Jach, Zuzanna Drulis-Kawa and R.J. Wiglusz
- Academic press:
- Biomolecules (year: 2021, volume: 11, pages: 1388), Publisher: MDPI Publisher of Open Access Journals
- Status:
- Published
- DOI:
- 10.3390/biom11091388 – link to the publication
-
New Approach to Antifungal Activity of Fluconazole Incorporated into the Porous 6-Anhydro- α-L-Galacto-β-D-Galactan Structures Modified with Nanohydroxyapatite for Chronic-Wound Treatments - In Vitro Evaluation
- Authors:
- J. Rewak-Soroczynska, P. Sobierajska, S. Targonska, A. Piecuch, L. Grosman, J. Rachuna, S. Wasik, M. Arabski, R. Ogorek and R.J. Wiglusz
- Academic press:
- International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 3112), Publisher: MDPI Publisher of Open Access Journals
- Status:
- Published
- DOI:
- 10.3390/ijms22063112 – link to the publication
-
Three dimensional (3D) printed polylactic acid with nano-hydroxyapatite doped with europium(III) ions (nHAp/PLLA@Eu3+) composite for osteochondral defect regeneration and theranostics
- Authors:
- K. Marycz, A. Smieszeka, S. Targonska, S.A. Walsh, K. Szustakiewicz, R.J. Wiglusz
- Academic press:
- Materials Science & Engineering C (year: 2020, volume: 110, pages: 110634), Publisher: Elsevier B.V.
- Status:
- Published
- DOI:
- 10.1016/j.msec.2020.110634 – link to the publication
-
Preparation of a New Biocomposite Designed for Cartilage Grafting with Antibiofilm Activity
- Authors:
- S. Targonska, J. Rewak-Soroczynska, A. Piecuch, E. Paluch, D. Szymanski, and R.J. Wiglusz
- Academic press:
- ACS Omega (year: 2020, volume: 5, pages: 24546-24557), Publisher: American Chemical Society Publications
- Status:
- Published
- DOI:
- 10.1021/acsomega.0c03044 – link to the publication
-
Structural modification of nanohydroxyapatite Ca10(PO4)6(OH)2 related to Eu3+ and Sr2+ ions doping and its spectroscopic and antimicrobial properties
- Authors:
- Katarzyna Szyszka, Justyna Rewak-Soroczynska, Agata Dorotkiewicz-Jach, Karolina A. Ledwa, Agata Piecuch, Michael Giersig, Zuzanna Drulis-Kawa, Rafal J. Wiglusz
- Academic press:
- Journal of Inorganic Biochemistry (year: 2020, volume: 203, pages: 110884), Publisher: Elsevier B.V.
- Status:
- Published
- DOI:
- 10.1016/j.jinorgbio.2019.110884 – link to the publication
-
Assessment of Microstructure and Release of Fluoride Ions from Selected Fissure Sealants: An In Vitro Study
- Authors:
- K. Fita, M. Dobrzyński, M. Ziętek, D. Diakowska, A. Watras and R.J. Wiglusz
- Academic press:
- Materials (year: 2021, volume: 14, pages: 4936), Publisher: MDPI Publisher of Open Access Journals
- Status:
- Published
- DOI:
- 10.3390/ma14174936 – link to the publication
-
In Vitro Studies concerning Selected Properties of a Composite Material Blended with Nanofluoroapatite Crystals
- Authors:
- M. Zietek, M. Dobrzynski, K. Fita, D. Diakowska, A. Watras and R.J. Wiglusz
- Academic press:
- Materials (year: 2021, volume: 14, pages: 7295), Publisher: MDPI Publisher of Open Access Journals
- Status:
- Published
- DOI:
- 10.3390/ma14237295 – link to the publication
-
Preparation and Characterization of Self-Assembled Poly(l-Lactide) on the Surface of β-Tricalcium Diphosphate(V) for Bone Tissue Theranostics
- Authors:
- J.A. Zienkiewicz, A. Strzep, D. Jedrzkiewicz, N. Nowak, J. Rewak-Soroczynska, A. Watras, J. Ejfler and R.J. Wiglusz
- Academic press:
- Nanomaterials — Open Access Journal (year: 2020, volume: 10, pages: 331), Publisher: MDPI Publisher of Open Access Journals
- Status:
- Published
- DOI:
- 10.3390/nano10020331 – link to the publication
-
Application of Selected Nanomaterials and Ozone in Modern Clinical Dentistry
- Authors:
- A. Lubojanski, M. Dobrzynski, N. Nowak, J. Rewak-Soroczynska, K. Sztyler, W. Zakrzewski, W. Dobrzynski, M. Szymonowicz, Z. Rybak, K. Wiglusz and R.J. Wiglusz
- Academic press:
- Nanomaterials (year: 2021, volume: 11, pages: 259), Publisher: MDPI Publisher of Open Access Journals
- Status:
- Published
- DOI:
- 10.3390/nano11020259 – link to the publication
-
The Influence of Ozonated Olive Oil-Loaded and Copper-Doped Nanohydroxyapatites on Planktonic Forms of Microorganisms
- Authors:
- W. Zakrzewski, M. Dobrzynski, J. Nowicka, M. Pajaczkowska, M. Szymonowicz, S. Targonska, P. Sobierajska, K. Wiglusz, W. Dobrzynski, A. Lubojanski, S. Fedorowicz, Z. Rybak and R.J. Wiglusz
- Academic press:
- Nanomaterials — Open Access Journal (year: 2020, volume: 10, pages: 1997), Publisher: MDPI Publisher of Open Access Journals
- Status:
- Published
- DOI:
- 10.3390/nano10101997 – link to the publication
-
The Influence of a Knitted Hydrophilic Prosthesis of Blood Vessels on the Activation of Coagulation System - In Vitro Study
- Authors:
- M. Szymonowicz, M. Dobrzynski, S. Targonska, A. Rusak, Z. Rybak, M.H. Struszczyk, J. Majda, D. Szymanski and R.J. Wiglusz
- Academic press:
- Nanomaterials (year: 2021, volume: 11, pages: 1600), Publisher: MDPI Publisher of Open Access Journals
- Status:
- Published
- DOI:
- 10.3390/nano11061600 – link to the publication
-
Nanostructural Materials with Rare Earth Ions: Synthesis, Physicochemical Characterization, Modification and Applications
- Authors:
- R.J. Wiglusz
- Academic press:
- Nanomaterials (year: 2021, volume: 11, pages: 1848), Publisher: MDPI Publisher of Open Access Journals
- Status:
- Published
- DOI:
- 10.3390/nano11071848 – link to the publication
-
Quenching of the Eu3+ Luminescence by Cu2+ Ions in the Nanosized Hydroxyapatite Designed for Future Bio-Detection
- Authors:
- K. Szyszka, S. Targońska, A. Lewińska, A. Watras and R.J. Wiglusz
- Academic press:
- Nanomaterials (year: 2021, volume: 11, pages: 464), Publisher: MDPI Publisher of Open Access Journals
- Status:
- Published
- DOI:
- 10.3390/nano11020464 – link to the publication
-
Selected Nanomaterials' Application Enhanced with the Use of Stem Cells in Acceleration of Alveolar Bone Regeneration during Augmentation Process
- Authors:
- W. Zakrzewski, M. Dobrzynski , Z. Rybak, M. Szymonowicz and R.J. Wiglusz
- Academic press:
- Nanomaterials — Open Access Journal (year: 2020, volume: 10, pages: 1216), Publisher: MDPI Publisher of Open Access Journals
- Status:
- Published
- DOI:
- 10.3390/nano10061216 – link to the publication
-
Theranostic Applications of Nanostructured Silicate-Substituted Hydroxyapatite Codoped with Eu3+ and Bi3+ Ions - A Novel Strategy for Bone Regeneration
- Authors:
- S. Targonska, M. Sikora, K. Marycz, A. Smieszek, and R.J. Wiglusz
- Academic press:
- ACS Biomaterials Science & Engineering (year: 2020, volume: 6, pages: 6148-6160), Publisher: American Chemical Society Publications
- Status:
- Published
- DOI:
- 10.1021/acsbiomaterials.0c00824 – link to the publication
-
Investigation of Physicochemical Properties of the Structurally Modified Nanosized Silicate-Substituted Hydroxyapatite Co-Doped with Eu3+ and Sr2+ Ions
- Authors:
- S. Targonska and R.J. Wiglusz
- Academic press:
- Nanomaterials (year: 2021, volume: 11, pages: 27), Publisher: MDPI Publisher of Open Access Journals
- Status:
- Published
- DOI:
- 10.3390/nano11010027 – link to the publication
-
Investigation of Pyrophosphates KYP2O7Co-Doped with Lanthanide Ions Useful for Theranostics
- Authors:
- Adam Watras, Marta Wujczyk, Michael Roecken, Katarzyna Kucharczyk, Krzysztof Marycz and Rafal J. Wiglusz
- Academic press:
- Nanomaterials — Open Access Journal (year: 2019, volume: 9, pages: 1597-1614), Publisher: MDPI Publisher of Open Access Journals
- Status:
- Published
- DOI:
- 10.3390/nano9111597 – link to the publication
-
The Potential Selective Cytotoxicity of Poly(L-Lactic Acid)-Based Scaffolds Functionalized with Nanohydroxyapatite and Europium (III) Ions toward Osteosarcoma Cells
- Authors:
- Mateusz Sikora, Klaudia Marcinkowska, Krzysztof Marycz, Rafał Jakub Wiglusz and Agnieszka Śmieszek
- Academic press:
- Materials— Open Access Journal (year: 2019, volume: 12, pages: 3779-3799), Publisher: MDPI Publisher of Open Access Journals
- Status:
- Published
- DOI:
- 10.3390/ma12223779 – link to the publication
-
Nanohydroxyapatite as a Biomaterial for Peripheral Nerve Regeneration after Mechanical Damage - In Vitro Study
- Authors:
- B. Wiatrak, P. Sobierajska, M. Szandruk-Bender, P. Jawien, M. Janeczek, M. Dobrzynski, P. Pistor, A. Szelag and R.J. Wiglusz
- Academic press:
- International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 4454), Publisher: MDPI Publisher of Open Access Journals
- Status:
- Published
- DOI:
- 10.3390/ijms22094454 – link to the publication
-
The Comprehensive Approach to Preparation and Investigation of the Eu3+ Doped Hydroxyapatite/poly(L-lactide) Nanocomposites: Promising Materials for Theranostics Application
- Authors:
- Katarzyna Szyszka, Sara Targonska, Malgorzata Gazinska, Konrad Szustakiewicz and Rafal J.Wiglusz
- Academic press:
- Nanomaterials — Open Access Journal (year: 2019, volume: 9, pages: 1146-1162), Publisher: MDPI Publisher of Open Access Journals
- Status:
- Published
- DOI:
- 10.3390/nano9081146 – link to the publication
-
A new approach to spectroscopic and structural studies of the nano-sized silicate-substituted hydroxyapatite doped with Eu3+ ions
- Authors:
- S. Targonska, K. Szyszka, J. Rewak-Soroczynska and R. J. Wiglusz
- Academic press:
- Dalton Transactions (year: 2019, volume: 48, pages: 8303–8316), Publisher: Royal Society of Chemistry Publishing
- Status:
- Published
- DOI:
- 10.1039/C9DT01025D – link to the publication
-
Preparation and preliminary evaluation of bio-nanocomposites based on hydroxyapatites with antibacterial properties against anaerobic bacteria
- Authors:
- Katarzyna Zawisza, Paulina Sobierajska, Nicole Nowak, Anna Kedziora, Kamila Korzekwa, Blazej Pozniak, Marta Tikhomirov, Julia Miller, Lucyna Mrowczynska, Rafal J. Wiglusz
- Academic press:
- Materials Science and Engineering C (year: 2020, volume: 106, pages: 110295), Publisher: Elsevier B.V.
- Status:
- Published
- DOI:
- 10.1016/j.msec.2019.110295 – link to the publication
-
Preliminary In Vitro Study of Fluoride Release from Selected Ormocer Materials
- Authors:
- P. Kosior, M. Dobrzynski, A. Zakrzewska, L. Grosman, M. Korczynski, T. Blicharski, M. Gutbier, A. Watras and R.J. Wiglusz
- Academic press:
- Materials (year: 2021, volume: 14, pages: 2244), Publisher: MDPI Publisher of Open Access Journals
- Status:
- Published
- DOI:
- 10.3390/ma14092244 – link to the publication
-
In Vitro Assessment of Long-Term Fluoride Ion Release from Nanofluorapatite
- Authors:
- K. Herman, M. Wujczyk, M. Dobrzynski, D. Diakowska, K. Wiglusz and R.J. Wiglusz
- Academic press:
- Materials (year: 2021, volume: 14, pages: 3747), Publisher: MDPI Publisher of Open Access Journals
- Status:
- Published
- DOI:
- 10.3390/ma14133747 – link to the publication