Projects funded by the NCN

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Information of the project and the call

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Mitochondrial nucleoside diphosphate kinase (NDPK) as a regulator of mitochondrial proton leak catalyzed by purine nucleotide-binding proteins

2015/19/D/NZ3/00087

Keywords:

mitochondrial nucleoside diphosphate kinase mitochondria mitochondrial proton leak purine nucleotides uncoupling protein adenine nucleotide translocase

Descriptors:

  • NZ3_1:
  • NZ3_2:
  • NZ1_2:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Andrzej Marek Woyda-Płoszczyca 

Number of co-investigators in the project: 2

Call: SONATA 10 - announced on 2015-09-15

Amount awarded: 537 600 PLN

Project start date (Y-m-d): 2016-06-17

Project end date (Y-m-d): 2022-12-16

Project duration:: 78 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (8)
  1. How can the commercial potential of microalgae from the Dunaliella genus be improved? The importance of nucleotide metabolism with a focus on nucleoside diphosphate kinase (NDPK)
    Authors:
    Woyda-Ploszczyca A.M., Rybak A.S.
    Academic press:
    Algal Research (rok: 2021, tom: 60, strony: 102474), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.algal.2021.102474 - link to the publication
  2. Nucleoside diphosphate kinase strongly promotes GDP and ADP metabolism in the cell and affects endogenous proton leak in mitochondria – the kinase is hampered by oxidative phosphorylation inhibitors
    Authors:
    Woyda-Ploszczyca A.M.
    Academic press:
    Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2025, tom: 40 (1), strony: 2520611), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/14756366.2025.2520611 - link to the publication
  3. The conserved regulation of mitochondrial uncoupling proteins: From unicellular eukaryotes to mammals
    Authors:
    Woyda-Ploszczyca A.M., Jarmuszkiewicz W.
    Academic press:
    Biochimica et Biophysica Acta - Bioenergetics (rok: 2017, tom: 1858, strony: 21-33), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.003 - link to the publication
  4. Direct and indirect targets of carboxyatractyloside, including overlooked toxicity toward nucleoside diphosphate kinase (NDPK) and mitochondrial H+ leak
    Authors:
    Woyda-Ploszczyca A.M.
    Academic press:
    Pharmaceutical Biology (rok: 2023, tom: 61, strony: 372–390), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1080/13880209.2023.2168704 - link to the publication
  1. Nucleoside diphosphate kinase (NDPK) and its substrates in the light of mitochondrial proton leak regulation
    Authors:
    Woyda-Ploszczyca A.M., Jarmuszkiewicz W.
    Conference:
    6th Mitochondrion 2017 – Bioenergetics update (rok: 2017, ), Wydawca: Wydział Biologii, Uniwersytet im. A. Mickiewicza w Poznaniu
    Data:
    konferencja 43077
    Status:
    Published
  2. Badania złożonego metabolizmu nukleotydów, w tym aktywności kinazy difosforanów nukleozydów (NDPK), jako nowa nadzieja zwiększająca komercyjne wykorzystanie mikroglonów z rodzaju Dunaliella (Chlorophyta, Dunaliellaceae)
    Authors:
    Rybak A., Woyda-Płoszczyca A.
    Conference:
    Hydromicro 2021 (rok: 2021, ), Wydawca: Uniwersytet Gdański
    Data:
    konferencja 2021-06-od 09 do 11
    Status:
    Published
  3. Mitochondrial nucleoside diphosphate kinase (mNDPK) alleviates the GDP-dependent inhibition of ADP/ATP carrier(AAC)-mediated mitochondrial proton leak
    Authors:
    Woyda-Ploszczyca A.M., Jarmuszkiewicz W.
    Conference:
    IV Konferencja Naukowo-Dydaktyczna Wydziału Biologii Uniwersytetu im. Adama Mickiewicza – Wyzwania współczesnej biologii, biotechnologii, bioinformatyki i ochrony środowiska (rok: 2017, ), Wydawca: UAM w Poznaniu
    Data:
    konferencja 2017-04-od 06 do 08
    Status:
    Published
  4. Importance of nucleotide metabolism for the commercial potential of Dunaliella spp. (Dunaliellaceae, Chlorophyta)
    Authors:
    Rybak A.S., Woyda-Ploszczyca A.M.
    Conference:
    39th International Conference of the Polish Phycological Society (rok: 2021, ), Wydawca: Uniwersytet Gdański
    Data:
    konferencja 2021-09-od 27 do 30
    Status:
    Published
  5. Is mitochondrial NDPK involved in the regulation of the GDP inhibitory effect on uncoupling proteins?
    Authors:
    Woyda-Ploszczyca A.M., Jarmuszkiewicz W.
    Conference:
    BIO 2016 Congress (rok: 2016, ), Wydawca: Polish Biochemical Society - Acta Biochimica Polonica 63 (Supplement 2/2016)
    Data:
    konferencja 2016-09-od 13 do 16
    Status:
    Published
  6. The significance of nucleoside diphosphate kinase (NDPK)-dependent transphosphorylation for ADP/ATP carrier (AAC)-mediated mitochondrial proton leak of yeast Saccharomyces cerevisiae
    Authors:
    Woyda-Ploszczyca A.M., Jarmuszkiewicz W.
    Conference:
    PURINES 2018 International – Basic and translational science on purinergic signaling and its components for a healthy and better world (rok: 2018, ), Wydawca: Brazilian Purine Club
    Data:
    konferencja 2018-06-od 19 do 22
    Status:
    Published
  7. Badania wymagań temperaturowych i tlenowych termofilnego krasnorostu Compsopogon caeruleus (Compsopogonaceae, Rhodophyta) występującego w wodach jeziora Licheńskiego
    Authors:
    Rybak A.S., Woyda-Ploszczyca A.M.
    Conference:
    25 Zjazd Hydrobiologów Polskich (rok: 2022, ), Wydawca: Polskie Towarzystwo Hydrobiologiczne
    Data:
    konferencja 2022-09-od 07 do 09
    Status:
    Published
  8. Saccharomyces cerevisiae model sheds a new light on the activity of ADP/ATP carrier (AAC) – the importance of nucleoside diphosphate kinase (NDPK)
    Authors:
    Woyda-Ploszczyca A.M.
    Conference:
    7th Mitochondrion 2018 – Mitochondria in the spotlight (rok: 2018, ), Wydawca: Wydział Biotechnologii, Uniwersytet Wrocławski
    Data:
    konferencja 2018-10-od 18 do 19
    Status:
    Published

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