Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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RecA independent response of tubercle bacilli to DNA damage

2015/19/B/NZ6/02978

Keywords:

M. tuberculosis DNA repair pathogenesis

Descriptors:

  • NZ6_4: Bacteriology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Instytut Biologii Medycznej Polskiej Akademii Nauk

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Brzostek 

Number of co-investigators in the project: 4

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 908 400 PLN

Project start date (Y-m-d): 2016-08-26

Project end date (Y-m-d): 2021-08-25

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. system FPLC.
  2. wirówka preparatywna z rotorem kontowym. (60 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. ATP-Dependent Ligases and AEP Primases Affect the Profile and Frequency of Mutations in Mycobacteria under Oxidative Stress
    Authors:
    Anna Brzostek, Filip Gąsior, Jakub Lach, Lidia Żukowska, Ewelina Lechowicz, Małgorzata Korycka-Machała, Dominik Strapagiel, Jarosław Dziadek
    Academic press:
    Genes (Basel) (rok: 2021, tom: 12(4), strony: 547), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes12040547 - link to the publication
  2. Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C
    Authors:
    Brissett NC, Zabrady K, Płociński P, Bianchi J, Korycka-Machała M, Brzostek A, Dziadek J, Doherty AJ.
    Academic press:
    NATURE COMMUNICATIONS (rok: 2020, tom: 11, strony: Article Number 4196), Wydawca: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
    Status:
    Published
    DOI:
    10.1038/s41467-020-18012-8 - link to the publication
  3. Targeting DNA repair systems in antitubercular drug development.
    Authors:
    Minias A, Brzostek A, Dziadek J.
    Academic press:
    Current Medicinal Chemistry (rok: 2019, tom: 26, strony: 1494-1505), Wydawca: Bentham Science Publ LTD
    Status:
    Published
    DOI:
    10.2174/0929867325666180129093546 - link to the publication
  4. Dissecting the RecA-(In)dependent Response to Mitomycin C in Mycobacterium tuberculosis Using Transcriptional Profiling and Proteomics Analyses
    Authors:
    Anna Brzostek, Przemysław Płociński, Alina Minias, Aneta Ciszewska, Filip Gąsior, Jakub Pawełczyk, Bożena Dziadek, Marcin Słomka, Jarosław Dziadek
    Academic press:
    Cells (rok: 2021, tom: 10(5), strony: 4196), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10051168 - link to the publication

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