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Metabolic and behavioral characterization of mice with conditional knockout of Tcf7l2, a risk gene for diabetes and schizophrenia

2015/19/B/NZ4/03571

Keywords

Descriptors

  • NZ4_11: Metabolizm
  • NZ4_7: Neurofizjologia
  • NZ4_4: Patofizjologia ogólna

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Andrzej Paweł Nagalski

Number of co-investigators in the project: 5

Call

OPUS 10 – announced on 2015-09-15

Amount awarded
671 460 PLN
Project start date
2016-07-12
Project end date
2020-05-11
Project duration
46 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Homogenizator obrotowy do tkanek. Cost: 12 100 PLN
  2. System do anestezji wziewnej.
  3. zestaw komputerowy z oprogramowanie specjalistycznym. Cost: 11 600 PLN

Information in the final report

Publication in academic press/journals (4)

  1. PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke

    Authors:
    Jarosław Mazuryk, Izabela Puchalska, Kamil Koziński, Magdalena J Ślusarz, Jarosław Ruczyński, Piotr Rekowski, Piotr Rogujski , Rafał Płatek, Marta Barbara Wiśniewska, Arkadiusz Piotrowski, Łukasz Janus, Piotr M Skowron, Michał Pikuła, Paweł Sachadyn, Sylwia Rodziewicz-Motowidło, Artur Czupryn, Piotr Mucha
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 6086), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22116086 – link to the publication

  2. TCF7L2 regulates postmitotic differentiation programs and excitability patterns in the thalamus

    Authors:
    Marcin Andrzej Lipiec, Joanna Bem, Kamil Koziński, Chaitali Chakraborty, Joanna Urban-Ciećko, Tomasz Zajkowski, Michał Dąbrowski, Łukasz Mateusz Szewczyk, Angel Toval, José Luis Ferran, Andrzej Nagalski, Marta Barbara Wiśniewska
    Academic press:
    Development (year: 2020, volume: Online, pages: Online), Publisher: The Company of Biologists
    Status:
    Published
    DOI:
    10.1242/dev.190181 – link to the publication

  3. Wnt/β‐catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind

    Authors:
    Joanna Bem, Nikola Brożko, Chaitali Chakraborty, Marcin A Lipiec, Kamil Koziński, Andrzej Nagalski, Łukasz M Szewczyk, Marta B Wiśniewska
    Academic press:
    FEBS Letters (year: 2019, volume: 593 (13), pages: 1654-1674), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/1873-3468.13502 – link to the publication

  4. Metabolic pathways in the periphery and brain: Contribution to mental disorders?

    Authors:
    Nagalski Andrzej, Kozinski Kamil, Wisniewska B Marta
    Academic press:
    The International Journal of Biochemistry & Cell Biology (year: 2016, volume: 80, pages: 19-30), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2016.09.012 – link to the publication

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Graphic design and implementation: Jakub Piotrowski