Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Metabolic and behavioral characterization of mice with conditional knockout of Tcf7l2, a risk gene for diabetes and schizophrenia

2015/19/B/NZ4/03571

Keywords:

brain thalamus gene expression energy metabolism in the brain TCF7L2 transcription factor

Descriptors:

  • NZ4_11: Metabolism
  • NZ4_7: Neurophysiology
  • NZ4_4: Pathophysiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Andrzej Nagalski 

Number of co-investigators in the project: 5

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 671 460 PLN

Project start date (Y-m-d): 2016-07-12

Project end date (Y-m-d): 2020-05-11

Project duration:: 46 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. zestaw komputerowy z oprogramowanie specjalistycznym (11 600 PLN)
  2. Homogenizator obrotowy do tkanek (12 100 PLN)
  3. System do anestezji wziewnej.

Information in the final report

  • Publication in academic press/journals (4)
  1. PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke
    Authors:
    Jarosław Mazuryk, Izabela Puchalska, Kamil Koziński, Magdalena J Ślusarz, Jarosław Ruczyński, Piotr Rekowski, Piotr Rogujski , Rafał Płatek, Marta Barbara Wiśniewska, Arkadiusz Piotrowski, Łukasz Janus, Piotr M Skowron, Michał Pikuła, Paweł Sachadyn, Sylwia Rodziewicz-Motowidło, Artur Czupryn, Piotr Mucha
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 6086), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22116086 - link to the publication
  2. TCF7L2 regulates postmitotic differentiation programs and excitability patterns in the thalamus
    Authors:
    Marcin Andrzej Lipiec, Joanna Bem, Kamil Koziński, Chaitali Chakraborty, Joanna Urban-Ciećko, Tomasz Zajkowski, Michał Dąbrowski, Łukasz Mateusz Szewczyk, Angel Toval, José Luis Ferran, Andrzej Nagalski, Marta Barbara Wiśniewska
    Academic press:
    Development (rok: 2020, tom: Online, strony: Online), Wydawca: The Company of Biologists
    Status:
    Published
    DOI:
    10.1242/dev.190181 - link to the publication
  3. Wnt/β‐catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind
    Authors:
    Joanna Bem, Nikola Brożko, Chaitali Chakraborty, Marcin A Lipiec, Kamil Koziński, Andrzej Nagalski, Łukasz M Szewczyk, Marta B Wiśniewska
    Academic press:
    FEBS Letters (rok: 2019, tom: 593 (13), strony: 1654-1674), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/1873-3468.13502 - link to the publication
  4. Metabolic pathways in the periphery and brain: Contribution to mental disorders?
    Authors:
    Nagalski Andrzej, Kozinski Kamil, Wisniewska B Marta
    Academic press:
    The International Journal of Biochemistry & Cell Biology (rok: 2016, tom: 80, strony: 19-30), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2016.09.012 - link to the publication

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