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Mooving beyond 'good enough': in search of novel chelators for Cu-64, Ga-68 and Zr-89 radiometals

2015/19/B/ST5/00413

Keywords

Descriptors

  • ST5_14: Chemia koordynacyjna
  • ST5_16: Chemia biologiczna
  • ST5_24: Chemia nieorganiczna

Panel

ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution

Uniwersytet Wrocławski, Wydział Chemii

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Elżbieta Gumienna-Kontecka

Number of co-investigators in the project: 4

Call

OPUS 10 – announced on 2015-09-15

Amount awarded
1 098 400 PLN
Project start date
2016-06-14
Project end date
2021-03-13
Project duration
57 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer stacjonarny. Cost: 8 000 PLN
  2. Oprogramowanie ChemDraw. Cost: 7 057 PLN
  3. Pompa próżniowa. Cost: 15 000 PLN
  4. Program ORIGIN PRO 2020B. Cost: 4 391 PLN
  5. Spektrometr CD. Cost: 446 000 PLN
  6. Wyparka rotacyjna. Cost: 15 000 PLN

Information in the final report

Publication in academic press/journals (8)

  1. Thermodynamic Stability and Speciation of Ga(III) and Zr(IV) Complexes with High-Denticity Hydroxamate Chelators

    Authors:
    Yuliya Toporivska, Andrzej Mular, Karolina Piasta, Małgorzata Ostrowska, Davide Illuminati, Andrea Baldi, Valentina Albanese, Salvatore Pacifico, Igor O. Fritsky, Maurizio Remelli, Remo Guerrini, and Elzbieta Gumienna-Kontecka
    Academic press:
    Inorganic Chemistry (year: 2021, volume: 60, pages: 13332-13337), Publisher: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.1c01622 – link to the publication

  2. Synthesis, crystal structure and magnetic properties of new copper(II) complexes based on 3-(2-pyridyl)-1,2,4-triazole

    Authors:
    Yuliia P. Petrenko, Dmytro M. Khomenko, Roman O. Doroshchuk, Sergiu Shova, Ghénadie Novitchi, Karolina Piasta, Elzbieta Gumienna-Kontecka, Rostyslav D. Lampeka
    Academic press:
    Inorganica Chimica Acta (year: 2020, volume: 500, pages: 119216), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ica.2019.119216 – link to the publication

  3. An investigation of two copper(II) complexes with a triazole derivative as a ligand: magnetic and catalytic properties

    Authors:
    Yuliia P. Petrenko, Karolina Piasta, Dmytro M. Khomenko, Roman O. Doroshchuk, Sergiu Shova, Ghenadie Novitchi, Yuliya Toporivska, Elzbieta Gumienna-Kontecka, Luısa M. D. R. S. Martins and Rostyslav D. Lampeka
    Academic press:
    RSC Advances (year: 2021, volume: 11, pages: 23442-23449), Publisher: RSC
    Status:
    Published
    DOI:
    10.1039/d1ra03107d – link to the publication

  4. Exploring the Specificity of Rationally Designed Peptides Reconstituted from the Cell-Free Extract of Deinococcus radiodurans toward Mn(II) and Cu(II)

    Authors:
    Massimiliano Peana,* Elzbieta Gumienna-Kontecka,* Francesca Piras, Malgorzata Ostrowska, Karolina Piasta, Karolina Krzywoszynska, Serenella Medici, Maria Antonietta Zoroddu
    Academic press:
    Inorganic Chemistry (year: 2020, volume: 59, pages: 4661-4684), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.9b03737 – link to the publication

  5. Cu(II), Ni(II) and Zn(II) mononuclear building blocks based on new polynucleating azomethine ligand: Synthesis and characterization

    Authors:
    Karolina Zdyb, Maxym O. Plutenko, Rostislav D. Lampeka, Matti Haukka, Malgorzata Ostrowska, Igor O. Fritsky, Elzbieta Gumienna-Kontecka
    Academic press:
    Polyhedron (year: 2017, volume: 137, pages: 60-71), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.poly.2017.07.009 – link to the publication

  6. Non-symmetrical bis(aminoalkyl)phosphinates: new ligands with the enhanced binding of Cu(II) ions

    Authors:
    Karolina Piasta, Anna Dziełak, Artur Mucha, Elżbieta Gumienna-Kontecka
    Academic press:
    New Journal of Chemistry (year: 2018, volume: 42, pages: 7737--7745), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C8NJ01094C – link to the publication

  7. The solution thermodynamic stability of desferrioxamine B (DFO) with Zr(IV)

    Authors:
    Yuliya Tporivska, Elżbieta Gumienna-Kontecka
    Academic press:
    Journal Inorganic Biochemistry (year: 2019, volume: 198, pages: 110753), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2019.110753 – link to the publication

  8. Cyclic Analogs of Desferrioxamine E Siderophore for 68Ga Nuclear Imaging: Coordination Chemistry and Biological Activity in Staphylococcus aureus

    Authors:
    Andrzej Mular, Abraham Shanzer, Henryk Kozłowski, Isabella Hubmann, Matthias Misslinger, Julia Krzywik, Clemens Decristoforo, and Elzbieta Gumienna-Kontecka
    Status:
    Accepted for publication

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