Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of exogenous and endogenous intestinal alkaline phosphatase in exeperimental colitis of high fat fed mice

2015/19/B/NZ4/03130

Keywords:

colitis alkaline phosphatase LPS endotoxaemia physical exercise

Descriptors:

  • NZ4_2: Physiology
  • NZ4_4: Pathophysiology
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Tomasz Brzozowski 

Number of co-investigators in the project: 8

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 661 800 PLN

Project start date (Y-m-d): 2016-07-22

Project end date (Y-m-d): 2020-07-21

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Odwrócony transmisyjny mikroskop do histologicznych aplikacji z możliwością cyfrowej archiwizacji obrazu oraz stolikiem do automatycznego skanowania preparatu i opcją fluorescencji.
  2. Zestaw 10 klatek bytowych z kółkiem i komputerem (75 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (4)
  1. Alternative Therapy in Prevention of Experimental and Clinical Inflammatory Bowel Diseases. Impact of Regular Physical Activity, Intestinal Alkaline Phosphatase and Herbal Products
    Authors:
    Jan Bilski, Dagmara Wojcik, Aleksandra Danielak, Agnieszka Mazur-Bialy Marcin Magierowski, Katherine Tønnesen, Marcin Surmiak, Katarzyna Magierowska, Zbigniew Sliwowski, Robert Pajdo, Slawomir Kwiecien, Agata Ptak-Belowska Tomasz Brzozowski
    Academic press:
    Current Pharmaceutical Design (rok: 2020, tom: 26, strony: 2936-2950), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1381612826666200427090127 - link to the publication
  2. Intestinal Protection Induced by Treatment with Alkaline Phosphatase on the Severity of Experimental Colitis in Obese Mice Subjected to Forced Treadmill Running. Role of Proinflammatory Biomarkers, Intestinal Barrier Proteins and Oxidative Stress
    Authors:
    Dagmara Wojcik, Aleksandra Danielak, Agnieszka Mazur-Bialy, Marcin Surmiak, Marcin Magierowski, Zbigniew Sliwowski, Katarzyna Magierowska, Slawomir Kwiecien, Anna Chmura, Aneta Targosz, Agata Ptak-Belowska, Jan Bilski, Tomasz Brzozowski
    Academic press:
    Gastroenterology (rok: 2020, tom: 158(6), strony: S-763), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/S0016-5085(20)32582-8 - link to the publication
  3. The Combination of Intestinal Alkaline Phosphatase Treatment with Moderate Physical Activity Alleviates the Severity of Experimental Colitis in Obese Mice via Modulation of Gut Microbiota, Attenuation of Proinflammatory Cytokines, Oxidative Stress Biomarkers and DNA Oxidative Damage in Colonic Mucosa
    Authors:
    Wojcik-Grzybek D, Hubalewska-Mazgaj M, Surmiak M, Sliwowski Z, Dobrut A, Mlodzinska A, Wojcik A, Kwiecien S, Magierowski M, Mazur-Bialy A, Bilski J, Brzozowski T
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23(6), strony: 2964), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23062964 - link to the publication
  4. Intestinal Alkaline Phosphatase Combined with Voluntary Physical Activity Alleviates Experimental Colitis in Obese Mice. Involvement of Oxidative Stress, Myokines, Adipokines and Proinflammatory Biomarkers
    Authors:
    Danielak A, Wojcik D, Mazur-Bialy A, Surmiak M, Bilski J, Targosz A, Magierowski M, Chmura A, Strzalka M, Krzysiek-Maczka G, Magierowska K, Szczyrk U, Kwiecien S, Ptak-Belowska A, Brzozowski T.
    Academic press:
    Antioxidants (Basel) (rok: 2021, tom: 10(2), strony: 240), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox10020240 - link to the publication
  5. Role of Obesity, Mesenteric Adipose Tissue, and Adipokines in Inflammatory Bowel Diseases
    Authors:
    Jan Bilski, Agnieszka Mazur-Bialy, Dagmara Wójcik, Marcin Surmiak, Marcin Magierowski, Zbigniew Sliwowski, Robert Pajdo, Slawomir Kwiecien, Aleksandra Danielak, Agata Ptak-Belowska, Thomas Brzozowski.
    Academic press:
    Biomolecules (rok: 2019, tom: 9, strony: 780), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom9120780 - link to the publication
  6. Effect of Forced Physical Activity on the Severity of Experimental Colitis in Normal Weight and Obese Mice. Involvement of Oxidative Stress and Proinflammatory Biomarkers
    Authors:
    Jan Bilski, Agnieszka Mazur-Biały, Dagmara Wójcik, Marcin Magierowski, Marcin Surmiak, Sławomir Kwiecień, Katarzyna Magierowska, Magdalena Hubalewska-Mazgaj, Zbigniew Sliwowski, Tomasz Brzozo
    Academic press:
    Nutrients (rok: 2019, tom: 11, strony: 45310), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu11051127 - link to the publication
  1. Novel insight into mechanism of healing of experimental colitis by intestinal alkaline phosphatase in obese mice subjected to forced treadmill exercise. Involvement of oxidative stress, proinflammatory biomarkers and intestinal barrier proteins
    Authors:
    D. Wojcik, A. Danielak, M. Strzalka, M. Magierowski, A. Targosz, G. Krzysiek-Maczka, K. Magierowska, N. Kwiecien, R. Pajdo, A. Ptak-Belowska,T. Brzozowski,
    Conference:
    28th United European Gastroenterology Week Virtual 2020 (rok: 2020, ), Wydawca: United European Gastroenterology Journal
    Data:
    konferencja Październik
    Status:
    Published
  2. The combination of alkaline phosphatase treatment with voluntary physical activity ameliorates the inflammation of liver and adipose tissue in murine colitis with abdominal obesity. Importance of cytokines, oxidative stress and adipomyokines
    Authors:
    D. Wojcik, A. Mazur-Bialy, A. Targosz, A. Danielak, G. Krzysiek-Maczka, M. Strzalka, M. Magierowski, S. Kwiecien, A. Chmura, J. Bilski, K. Magierowska, A. Ptak-Belowska, T. Brzozowski
    Conference:
    Digestive Diseases Week 2021 (rok: 2021, ), Wydawca: Gastroenteroly, Elsevier B.V.
    Data:
    konferencja Maj 21-23
    Status:
    Published
  3. . Voluntary exercise combined with concomitant alkaline phosphatase treatment resolves experimental colitis in obese mice by improving colonic microcirculation and attenuating inflammation, oxidative stress, and restoration of adiponectin/leptin ratio.
    Authors:
    D. Wojcik, A. Danielak, M. Strzalka, M. Magierowski, A. Targosz, G. Krzysiek-Maczka, K. Magierowska, N. Kwiecien, R. Pajdo, A. Ptak-Belowska and T. Brzozowski
    Conference:
    29th United European Gastroenterology Week (rok: 2021, ), Wydawca: United European Gastroenterology Journal
    Data:
    konferencja Październik
    Status:
    Published
  4. Intestinal alkaline phosphatase therapy counteracts the intensification of colitis in obese mice subjected to forced treadmill exercise by shaping the intestinal microbiota and attenuating of pro-inflammatory and oxidative stress biomarkers
    Authors:
    Wójcik-Grzybek, D.; Surmiak, M.; Kwiecien, S.; Sliwowski, Z.; Magierowski, M.; Bilski, J.; Mazur-Bialy, A.I.; Targosz, A.; Magierowska, K.; Ptak-Belowska, A.
    Conference:
    Digestive Diseases Week 2022 (rok: 2022, ), Wydawca: Gastroenteroly, Elsevier B.V.
    Data:
    konferencja Maj 21-24
    Status:
    Published

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