Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Blood-brain barrier impairment in hepatic encephalopathy: role of microRNA.

2015/19/B/NZ4/01902

Keywords:

hepatic encephalopathy ammonia cytokines blood brain barrier endothelial cells microRNA

Descriptors:

  • NZ4_12: Other related subjects
  • NZ5_3: Pathogenesis of human diseases
  • NZ7_15: Toxicology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Magdalena Zielińska 

Number of co-investigators in the project: 6

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 1 092 280 PLN

Project start date (Y-m-d): 2016-08-04

Project end date (Y-m-d): 2022-06-03

Project duration:: 70 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Aparatu do pomiaru wartości oporu elektrycznego komórek epitelialnych in vitro (50 000 PLN)
  2. Komputer z monitorem (2 szt.) (10 000 PLN)
  3. Aparat do elektroforezy białek (7 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (6)
  1. Insight into microRNAs-Mediated Communication between Liver and Brain: A Possible Approach for Understanding Acute Liver Failure?
    Authors:
    Orzeł-Gajowik K., Milewski K., Zielińska M.
    Academic press:
    Int. J. Mol. Sci. (rok: 2021, tom: 23(1), strony: 224), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23010224 - link to the publication
  2. Mitochondrial changes in rat brain endothelial cells associated with hepatic encephalopathy: relation to the blood-brain barrier dysfunction.
    Authors:
    Milewski K, Orzeł-Gajowik K., Zielińska M.
    Academic press:
    Neurochem. Res. (rok: 2022, tom: aheaad of print, strony: aheaad of print), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11064-022-03698-7 - link to the publication
  3. The Effect of TGF-β1 Reduced Functionality on the Expression of Selected Synaptic Proteins and Electrophysiological Parameters: Implications of Changes Observed in Acute Hepatic Encephalopathy
    Authors:
    Popek M., Bobula B., Orzeł-Gajowik K., Zielińska M.
    Academic press:
    Int. J. Mol. Sci. (rok: 2021, tom: 23(3), strony: 1081), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031081 - link to the publication
  4. Decreased Expression and Uncoupling of Endothelial Nitric Oxide Synthase in the Cerebral Cortex of Rats with Thioacetamide-Induced Acute Liver Failure
    Authors:
    Milewski K., Czarnecka A.M., Albercht J., Zielińska M.
    Academic press:
    Int. J. Mol. Sci. (rok: 2021, tom: 22(13), strony: 6662-6675), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22136662 - link to the publication
  1. Role of miR-122 in occludin decrease and blood-brain barrier alteration in hepaticenc ephalopathy
    Authors:
    Karolina Orzeł, Krzysztof Milewski K, Magdalena Zielińska
    Conference:
    5th International Conference of Cell Biology (rok: 2019, ), Wydawca: Kraków
    Data:
    konferencja 19-05-10
    Status:
    Published
  2. Altered expression of miRNAs may be instrumental in triggering the blood brain barrier disruption in hyperammonemia related or not related to hepatic failure.
    Authors:
    Magdalena Zielińska, Marta Obara-Michlewska, Krzysztof Milewski, Edyta Skonieczna, Inez Fręśko.
    Conference:
    20th International Symposium on Signal Transduction at the Blood-Brain Barriers (rok: 2017, ), Wydawca: Fluids Barriers CNS 14 (Suppl 2)
    Data:
    konferencja 13-15 wrzesień
    Status:
    Published
  3. Blood brain barrier leakage and integrin 1β deprivation in acute liver failure rat brain depends on altered MicroRNAs profile.
    Authors:
    Krzysztof Milewski, Edyta Skonieczna, Karolina Orzeł, Magdalena Zielińska
    Conference:
    21st International Symposium on Signal Transduction at the Blood-Brain Barriers (rok: 2019, ), Wydawca: Fluids Barriers CNS
    Data:
    konferencja 21-23 wrzesień
    Status:
    Published
  4. Customizable transepithelial/endothelial electrical resistance device with integrated multi-microelectrodes for the measurement of cellular barrier integrity.
    Authors:
    Orzeł K., Gajowik T., Zielińska M.
    Conference:
    XXII Polish Conference on Biocybernetics and Biomedical Engineering (rok: 2021, ), Wydawca: Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences
    Data:
    konferencja 05 19-21
    Status:
    Published
  5. Role of miR-183 in integrinB1 decrease and blood-brain barrier alteration in hepaticenc ephalopathy.
    Authors:
    Karolina Orzeł, Krzysztof Milewski, Magdalena Zielińska
    Conference:
    ISN-ASN Meeting (rok: 2019, ), Wydawca: Journal of Neurochemistry
    Data:
    konferencja 19-08-04
    Status:
    Published
  6. The increased expression of miR-122 and blood-brain barrier disruption in hepaticenc ephalopathy
    Authors:
    Karolina Orzeł, Krzysztof Milewski, Magdalena Zielińska
    Conference:
    20th International Congress of the Polish Pharmacological Society (rok: 2019, ), Wydawca: Polish Pharmacological Society
    Data:
    konferencja 19-06-05
    Status:
    Published

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