Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Blood-brain barrier impairment in hepatic encephalopathy: role of microRNA.

2015/19/B/NZ4/01902

Keywords:

hepatic encephalopathy ammonia cytokines blood brain barrier endothelial cells microRNA

Descriptors:

  • NZ4_12: Other related subjects
  • NZ5_3: Pathogenesis of human diseases
  • NZ7_15: Toxicology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Magdalena Zielińska 

Number of co-investigators in the project: 6

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 1 092 280 PLN

Project start date (Y-m-d): 2016-08-04

Project end date (Y-m-d): 2022-06-03

Project duration:: 70 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer z monitorem (2 szt.) (10 000 PLN)
  2. Aparat do elektroforezy białek (7 000 PLN)
  3. Aparatu do pomiaru wartości oporu elektrycznego komórek epitelialnych in vitro (50 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (6)
  1. Decreased Expression and Uncoupling of Endothelial Nitric Oxide Synthase in the Cerebral Cortex of Rats with Thioacetamide-Induced Acute Liver Failure
    Authors:
    Milewski K., Czarnecka A.M., Albercht J., Zielińska M.
    Academic press:
    Int. J. Mol. Sci. (rok: 2021, tom: 22(13), strony: 6662-6675), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22136662 - link to the publication
  2. Mitochondrial changes in rat brain endothelial cells associated with hepatic encephalopathy: relation to the blood-brain barrier dysfunction.
    Authors:
    Milewski K, Orzeł-Gajowik K., Zielińska M.
    Academic press:
    Neurochem. Res. (rok: 2022, tom: aheaad of print, strony: aheaad of print), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11064-022-03698-7 - link to the publication
  3. The Effect of TGF-β1 Reduced Functionality on the Expression of Selected Synaptic Proteins and Electrophysiological Parameters: Implications of Changes Observed in Acute Hepatic Encephalopathy
    Authors:
    Popek M., Bobula B., Orzeł-Gajowik K., Zielińska M.
    Academic press:
    Int. J. Mol. Sci. (rok: 2021, tom: 23(3), strony: 1081), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031081 - link to the publication
  4. Insight into microRNAs-Mediated Communication between Liver and Brain: A Possible Approach for Understanding Acute Liver Failure?
    Authors:
    Orzeł-Gajowik K., Milewski K., Zielińska M.
    Academic press:
    Int. J. Mol. Sci. (rok: 2021, tom: 23(1), strony: 224), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23010224 - link to the publication
  1. Altered expression of miRNAs may be instrumental in triggering the blood brain barrier disruption in hyperammonemia related or not related to hepatic failure.
    Authors:
    Magdalena Zielińska, Marta Obara-Michlewska, Krzysztof Milewski, Edyta Skonieczna, Inez Fręśko.
    Conference:
    20th International Symposium on Signal Transduction at the Blood-Brain Barriers (rok: 2017, ), Wydawca: Fluids Barriers CNS 14 (Suppl 2)
    Data:
    konferencja 13-15 wrzesień
    Status:
    Published
  2. Blood brain barrier leakage and integrin 1β deprivation in acute liver failure rat brain depends on altered MicroRNAs profile.
    Authors:
    Krzysztof Milewski, Edyta Skonieczna, Karolina Orzeł, Magdalena Zielińska
    Conference:
    21st International Symposium on Signal Transduction at the Blood-Brain Barriers (rok: 2019, ), Wydawca: Fluids Barriers CNS
    Data:
    konferencja 21-23 wrzesień
    Status:
    Published
  3. The increased expression of miR-122 and blood-brain barrier disruption in hepaticenc ephalopathy
    Authors:
    Karolina Orzeł, Krzysztof Milewski, Magdalena Zielińska
    Conference:
    20th International Congress of the Polish Pharmacological Society (rok: 2019, ), Wydawca: Polish Pharmacological Society
    Data:
    konferencja 19-06-05
    Status:
    Published
  4. Customizable transepithelial/endothelial electrical resistance device with integrated multi-microelectrodes for the measurement of cellular barrier integrity.
    Authors:
    Orzeł K., Gajowik T., Zielińska M.
    Conference:
    XXII Polish Conference on Biocybernetics and Biomedical Engineering (rok: 2021, ), Wydawca: Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences
    Data:
    konferencja 05 19-21
    Status:
    Published
  5. Role of miR-183 in integrinB1 decrease and blood-brain barrier alteration in hepaticenc ephalopathy.
    Authors:
    Karolina Orzeł, Krzysztof Milewski, Magdalena Zielińska
    Conference:
    ISN-ASN Meeting (rok: 2019, ), Wydawca: Journal of Neurochemistry
    Data:
    konferencja 19-08-04
    Status:
    Published
  6. Role of miR-122 in occludin decrease and blood-brain barrier alteration in hepaticenc ephalopathy
    Authors:
    Karolina Orzeł, Krzysztof Milewski K, Magdalena Zielińska
    Conference:
    5th International Conference of Cell Biology (rok: 2019, ), Wydawca: Kraków
    Data:
    konferencja 19-05-10
    Status:
    Published

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