Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Mechanism of epigenetic-driven inactivation of tumor suppressor SIGIRR

2015/19/B/NZ6/01578

Keywords:

receptor SIGIRR colorectal cancer epigenetic control TLR/IL-1R signaling

Descriptors:

  • NZ6_2: Clinical immunology
  • NZ5_3: Pathogenesis of human diseases
  • NZ2_2: Genomics, transcriptomics, epigenomics

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Bulek 

Number of co-investigators in the project: 5

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 2 000 000 PLN

Project start date (Y-m-d): 2016-10-03

Project end date (Y-m-d): 2022-04-02

Project duration:: 66 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer stacjonarny (6 000 PLN)
  2. zestaw do elektroforezy (9 243 PLN)
  3. Seahorse XFp Extracellular Flux Analyzer (260 000 PLN)
  4. licznik komórek (19 998 PLN)
  5. Pompa perystaltyczna (6 361 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis
    Authors:
    Bulek K, Zhao J, Liao Y, Rana N, Corridoni D, Antanaviciute A, Chen X, Wang H, Qian W, Miller-Little WA, Swaidani S, Tang F, Willard BB, McCrae K, Kang Z, Dubyak GR, Cominelli F, Simmons A, Pizarro TT, Li X.
    Academic press:
    The Journal of Clinical Investigation (rok: 2020, tom: 130(8), strony: 4218–4234), Wydawca: The American Society for Clinical Investigation
    Status:
    Published
    DOI:
    10.1172/JCI138103 - link to the publication
  2. The Ras GTPase-activating-like protein IQGAP1 bridges Gasdermin D to the ESCRT system to promote IL-1β release via exosomes
    Authors:
    Liao Y*, Chen X, Miller-Little W, Wang H, Willard B, Bulek K*, Zhao J*, Li X*, *corresponding author
    Academic press:
    The EMBO Journal (rok: 2022, tom: 45610, strony: e110780), Wydawca: EMBO press
    Status:
    Published
    DOI:
    10.15252/embj.2022110780 - link to the publication
  3. Dominant-Negative Form of SIGIRR: SIGIRRΔE8 Promotes Tumor Growth Through Regulation of Metabolic Pathways
    Authors:
    Bodaszewska-Lubas M, Liao Y, Zegar A, Szelest O, Dobrucki J, Bulek K*, *corresponding author
    Academic press:
    Journal of Interferon & Cytokine Research (rok: 2022, tom: 42(9), strony: 482-492), Wydawca: Mary Ann Liebert, Inc
    Status:
    Published
    DOI:
    10.1089/jir.2022.0095 - link to the publication

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