Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Analysis of relationsips between T cell exhaustion, genetic heterogeneity of hepatitis C virus (HCV) epitopes recognized by T cells and anti-HCV treatment in HCV-infected and HIV-1/HCV coinfected patients

2015/19/D/NZ6/01303

Keywords:

hepatitis C virus T cell exhaustion HCV epitopes heterogeneity next-generation sequencing antiviral treatment

Descriptors:

  • NZ6_5: Virology
  • NZ6_1: Adaptive and innate immunity

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Warszawski Uniwersytet Medyczny, Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Kamila Caraballo Cortés 

Number of co-investigators in the project: 3

Call: SONATA 10 - announced on 2015-09-15

Amount awarded: 876 240 PLN

Project start date (Y-m-d): 2016-07-08

Project end date (Y-m-d): 2022-04-07

Project duration:: 69 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Wirówka z chłodzeniem na probówki 15/50 ml oraz na probówki 1.5 ml z rotorem.
  2. Automatyczny Licznik Komórek EVE-MC firmy Nanoentek.
  3. Zamrażarka do głębokiego mrożenia (-80 stopni Celsjusza) (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  1. Reversal of T Cell Exhaustion in Chronic HCV Infection
    Authors:
    Sylwia Osuch, Karin J Metzner, Kamila Caraballo Cortés
    Academic press:
    Viruses (rok: 2020, tom: 12(8), strony: 799), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v12080799 - link to the publication
  2. T-cell exhaustion in HIV-1/HCV coinfected individuals is reduced following successful treatment of chronic hepatitis C
    Authors:
    Kamila Caraballo Cortés, Sylwia Osuch, Karol Perlejewski, Marek Radkowski, Maciej Janiak, Hanna Berak, Andri Rauch, Jan S. Fehr, Matthias Hoffmann, Huldrych F. Günthard, Karin J. Metzner
    Academic press:
    Open Forum Infectious Diseases (rok: 2023, tom: brak, strony: brak), Wydawca: Oxford Academic
    Status:
    Submitted
    DOI:
    brak - link to the publication
  3. Decrease of T-cells exhaustion markers programmed cell death-1 and T-cell immunoglobulin and mucin domain-containing protein 3 and plasma IL-10 levels after successful treatment of chronic hepatitis C
    Authors:
    Sylwia Osuch, Tomasz Laskus, Hanna Berak, Karol Perlejewski, Karin J Metzner, Marcin Paciorek, Marek Radkowski, Kamila Caraballo Cortés
    Academic press:
    Scientific Reports (rok: 2020, tom: 10(1), strony: 16060), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-020-73137-6 - link to the publication
  4. Hepatitis C virus (HCV) genotype 1b displays higher genetic variability of hypervariable region 1 (HVR1) than genotype 3
    Authors:
    Janiak Maciej , Perlejewski Karol , Grabarczyk Piotr , Kubicka-Russel Dorota , Zagordi Osvaldo , Berak Hanna , Osuch Sylwia , Pawełczyk Agnieszka Maria, Bukowska-Ośko Iwona Anna, Płoski Rafał Tomasz, Laskus Tomasz Jacek, Caraballo Cortés Kamila
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 12846), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-019-49258-y - link to the publication
  5. CD8+ T-cell exhaustion phenotype in chronic hepatitis C virus infection is associated with epitope sequence variation
    Authors:
    Osuch Sylwia , Laskus Tomasz Jacek, Perlejewski Karol , Berak Hanna , Bukowska-Ośko Iwona Anna, Pollak Agnieszka , Zielenkiewicz Magdalena , Radkowski Marek Mirosław, Caraballo Cortés Kamila
    Academic press:
    Frontiers in Immunology (rok: 2022, tom: 13, strony: 832206), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2022.832206 - link to the publication
  6. Double Positive CD4+CD8+ (DP) T-Cells Display Distinct Exhaustion Phenotype in Chronic Hepatitis C
    Authors:
    Kochanowicz Anna Maria, Osuch Sylwia, Berak Hanna, Kumorek Aleksandra, Caraballo Cortés Kamila.
    Academic press:
    Cells (rok: 2023, tom: 12, strony: 45304), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells12101446 - link to the publication
  7. Expression of programmed cell death protein 1 (PD-1) and T cell immunoglobulin and mucin domain-containing molecule-3 (Tim-3) on peripheral blood CD4+CD8+ double positive T cells in patients with chronic hepatitis C virus (HCV) infection and in subjects who spontaneously cleared the virus
    Authors:
    Kamila Caraballo Cortés (autor korespondujący), Sylwia Osuch, Karol Perlejewski, Agnieszka Pawełczyk, Justyna Kaźmierczak, Maciej Janiak, Joanna Jabłońska, Khalil Nazzal, Anna Stelmaszczyk-Emmel, Hanna Berak, Iwona Bukowska-Ośko, Marcin Paciorek, Tomasz Laskus, Marek Radkowski
    Academic press:
    Journal of Viral Hepatitis (rok: 2019, tom: 26 (8), strony: 942-950), Wydawca: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1111/jvh.13108 - link to the publication
  8. Next-generation sequencing analysis of a cluster of hepatitis C virus infections in a haematology and oncology center
    Authors:
    Caraballo Cortes K (autor korespondencyjny), Rosińska M, Janiak M, Stępień M, Zagordi O, Perlejewski K, Osuch S, Pawełczyk A, Bukowska-Ośko I, Płoski R, Grabarczyk P, Laskus T, Radkowski M.
    Academic press:
    PLoS One (rok: 2018, tom: 13(3), strony: e0194816.0.1371), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0194816 - link to the publication

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