Zmiana języka

Projects search

Analysis of relationsips between T cell exhaustion, genetic heterogeneity of hepatitis C virus (HCV) epitopes recognized by T cells and anti-HCV treatment in HCV-infected and HIV-1/HCV coinfected patients

2015/19/D/NZ6/01303

Keywords

Descriptors

  • NZ6_5: Wirusologia
  • NZ6_1: Odporność swoista i nieswoista

Panel

NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Kamila Caraballo Cortés

Number of co-investigators in the project: 3

Call

SONATA 10 – announced on 2015-09-15

Amount awarded
876 240 PLN
Project start date
2016-07-08
Project end date
2022-04-07
Project duration
69 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Automatyczny Licznik Komórek EVE-MC firmy Nanoentek.
  2. Wirówka z chłodzeniem na probówki 15/50 ml oraz na probówki 1.5 ml z rotorem.
  3. Zamrażarka do głębokiego mrożenia (-80 stopni Celsjusza). Cost: 30 000 PLN

Information in the final report

Publication in academic press/journals (7)

  1. Reversal of T Cell Exhaustion in Chronic HCV Infection

    Authors:
    Sylwia Osuch, Karin J Metzner, Kamila Caraballo Cortés
    Academic press:
    Viruses (year: 2020, volume: 12(8), pages: 799), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/v12080799 – link to the publication

  2. Decrease of T-cells exhaustion markers programmed cell death-1 and T-cell immunoglobulin and mucin domain-containing protein 3 and plasma IL-10 levels after successful treatment of chronic hepatitis C

    Authors:
    Sylwia Osuch, Tomasz Laskus, Hanna Berak, Karol Perlejewski, Karin J Metzner, Marcin Paciorek, Marek Radkowski, Kamila Caraballo Cortés
    Academic press:
    Scientific Reports (year: 2020, volume: 10(1), pages: 16060), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-020-73137-6 – link to the publication

  3. Next-generation sequencing analysis of a cluster of hepatitis C virus infections in a haematology and oncology center

    Authors:
    Caraballo Cortes K (autor korespondencyjny), Rosińska M, Janiak M, Stępień M, Zagordi O, Perlejewski K, Osuch S, Pawełczyk A, Bukowska-Ośko I, Płoski R, Grabarczyk P, Laskus T, Radkowski M.
    Academic press:
    PLoS One (year: 2018, volume: 13(3), pages: e0194816.0.1371), Publisher: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0194816 – link to the publication

  4. Expression of programmed cell death protein 1 (PD-1) and T cell immunoglobulin and mucin domain-containing molecule-3 (Tim-3) on peripheral blood CD4+CD8+ double positive T cells in patients with chronic hepatitis C virus (HCV) infection and in subjects who spontaneously cleared the virus

    Authors:
    Kamila Caraballo Cortés (autor korespondujący), Sylwia Osuch, Karol Perlejewski, Agnieszka Pawełczyk, Justyna Kaźmierczak, Maciej Janiak, Joanna Jabłońska, Khalil Nazzal, Anna Stelmaszczyk-Emmel, Hanna Berak, Iwona Bukowska-Ośko, Marcin Paciorek, Tomasz Laskus, Marek Radkowski
    Academic press:
    Journal of Viral Hepatitis (year: 2019, volume: 26 (8), pages: 942-950), Publisher: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1111/jvh.13108 – link to the publication

  5. Hepatitis C virus (HCV) genotype 1b displays higher genetic variability of hypervariable region 1 (HVR1) than genotype 3

    Authors:
    Janiak Maciej , Perlejewski Karol , Grabarczyk Piotr , Kubicka-Russel Dorota , Zagordi Osvaldo , Berak Hanna , Osuch Sylwia , Pawełczyk Agnieszka Maria, Bukowska-Ośko Iwona Anna, Płoski Rafał Tomasz, Laskus Tomasz Jacek, Caraballo Cortés Kamila
    Academic press:
    Scientific Reports (year: 2019, volume: 9, pages: 12846), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-019-49258-y – link to the publication

  6. CD8+ T-cell exhaustion phenotype in chronic hepatitis C virus infection is associated with epitope sequence variation

    Authors:
    Osuch Sylwia , Laskus Tomasz Jacek, Perlejewski Karol , Berak Hanna , Bukowska-Ośko Iwona Anna, Pollak Agnieszka , Zielenkiewicz Magdalena , Radkowski Marek Mirosław, Caraballo Cortés Kamila
    Academic press:
    Frontiers in Immunology (year: 2022, volume: 13, pages: 832206), Publisher: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2022.832206 – link to the publication

  7. Double Positive CD4+CD8+ (DP) T-Cells Display Distinct Exhaustion Phenotype in Chronic Hepatitis C

    Authors:
    Kochanowicz Anna Maria, Osuch Sylwia, Berak Hanna, Kumorek Aleksandra, Caraballo Cortés Kamila.
    Academic press:
    Cells (year: 2023, volume: 12, pages: 46035), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells12101446 – link to the publication

« New search

Graphic design and implementation: Jakub Piotrowski