Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The degradation products of tryptophan via kynurenine pathway in bone biomechanics and metabolism in chronic kidney disease

2015/19/N/NZ4/01347

Keywords:

chronic kidney disease biomechanical testing bone metabolism kynurenine pathway

Descriptors:

  • NZ4_4: Pathophysiology
  • NZ4_11: Metabolism

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Bartłomiej Kałaska 

Number of co-investigators in the project: 3

Call: PRELUDIUM 10 - announced on 2015-09-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2016-07-06

Project end date (Y-m-d): 2019-07-05

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Mikrowirówka wielofunkcyjna Eppendorf 5430 R w pakiecie z rotorami FA-45-48-11 i FA-45-16-17 (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (4)
  1. A link between central kynurenine metabolism and bone strength in rats with chronic kidney disease
    Authors:
    Bartlomiej Kalaska, Krystyna Pawlak, Ewa Oksztulska-Kolanek, Tomasz Domaniewski, Beata Znorko, Malgorzata Karbowska, Aleksandra Citkowska, Joanna Rogalska, Alicja Roszczenko, Malgorzata M. Brzoska, Dariusz Pawlak
    Academic press:
    PeerJ (rok: 2017, tom: 5, strony: e3199), Wydawca: PeerJ, Inc.
    Status:
    Published
    DOI:
    10.7717/peerj.3199 - link to the publication
  2. Elevated levels of peripheral kynurenine decrease bone strength in rats with chronic kidney disease
    Authors:
    Bartlomiej Kalaska, Krystyna Pawlak, Tomasz Domaniewski, Ewa Oksztulska-Kolanek, Beata Znorko, Alicja Roszczenko, Joanna Rogalska, Malgorzata M. Brzoska, Pawel Lipowicz, Michal Doroszko, Anna Pryczynicz, Dariusz Pawlak
    Academic press:
    Frontiers in Physiology (rok: 2017, tom: 8, strony: 836), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fphys.2017.00836 - link to the publication
  1. Association between central kynurenine metabolism and bone strenght in rats with chronic kidney disease
    Authors:
    Bartlomiej Kalaska, Krystyna Pawlak, Ewa Oksztulska-Kolanek, Tomasz Domaniewski, Beata Znorko, Małgorzata Karbowska, Aleksandra Citkowska, Piotr Jakubowski, Dariusz Pawlak
    Conference:
    54th ERA-EDTA Congress (rok: 2017, ), Wydawca: European Renal Association, European Dialysis and Transplant Association
    Data:
    konferencja 03.06.-06.06.
    Status:
    Published
  2. Kynurenine modulates bone strength in rats with chronic kidney diseases depending on the place of its occurrence
    Authors:
    Bartlomiej Kalaska, Krystyna Pawlak, Tomasz Domaniewski, Ewa Oksztulska-Kolanek, Beata Znorko, Małgorzata Karbowska, Adrian Mor, Malgorzata M. Brzoska, Pawel Lipowicz, Michal Doroszko, Anna Pryczynicz, Dariusz Pawlak
    Conference:
    WCO-IOF-ESCEO World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (rok: 2018, ), Wydawca: Osteoporosis International (Springer London LTD)
    Data:
    konferencja 19.04.-22.04.
    Status:
    Published
  3. The influence of tryptophan hydroxylase inhibitor LP533401 on kynurenine concentration in bone tissue in the experimental model of chronic kidney disease
    Authors:
    Bartlomiej Kalaska, Adrian Mor, Beata Sieklucka, Tomasz Domaniewski, Radosław Zawadzki, Urszula Lebkowska, Krystyna Pawlak, Dariusz Pawlak
    Conference:
    56th ERA-EDTA Congress (rok: 2019, ), Wydawca: European Renal Association, European Dialysis and Transplant Association
    Data:
    konferencja 13.06.-16.06.
    Status:
    Published
  4. Kynurenine in light of bone biomechanical properties in rats with experimental chronic kidney disease
    Authors:
    Bartlomiej Kalaska, Krystyna Pawlak, Ewa Oksztulska-Kolanek, Beata Znorko, Tomasz Domaniewski, Alicja Roszczenko, Joanna Rogalska, Malgorzata M. Brzoska, Dariusz Pawlak
    Conference:
    31st International Symposium on Chromatography (rok: 2016, ), Wydawca: Central European Group for Separation Sciences
    Data:
    konferencja 28.08.-01.09.
    Status:
    Published

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