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Endocytosis of AXL receptor and its role in AXL-mediated signaling.

2015/19/D/NZ3/03270

Keywords:

endocytosis endosomes AXL GAS6 receptor tyrosine kinases

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_7: Signal transduction

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Daria Zdżalik-Bielecka 

Number of co-investigators in the project: 3

Call: SONATA 10 - announced on 2015-09-15

Amount awarded: 762 929 PLN

Project start date (Y-m-d): 2016-08-19

Project end date (Y-m-d): 2020-08-18

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Bemcentinib and gilteritinib inhibit cell growth and impair the endo-lysosomal and autophagy systems in an AXL-independent manner
    Authors:
    Daria Zdzalik-Bielecka, Kamila Kozik, Agata Poswiata, Kamil Jastrzebski, Marta Jakubik, Marta Miaczynska
    Academic press:
    Molecular Cancer Research (rok: 2021, tom: brak, strony: brak), Wydawca: American Association for Cancer Research (USA)
    Status:
    Published
    DOI:
    10.1158/1541-7786.MCR-21-0444 - link to the publication
  2. The GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion
    Authors:
    Daria Zdżalik-Bielecka, Agata Poświata, Kamila Kozik, Kamil Jastrzębski, Kay Oliver Schink, Marta Brewińska-Olchowik, Katarzyna Piwocka, Harald Stenmark, Marta Miączyńska
    Academic press:
    Proceedings of the National Academy of Sciences of the United States of America (PNAS) (rok: 2021, tom: 118, strony: brak), Wydawca: National Academy of Sciences (NAS)
    Status:
    Published
    DOI:
    10.1073/pnas.2024596118 - link to the publication
  3. GAS6-induced endocytic trafficking of AXL displays a unique pattern associated with sustained AKT activation
    Authors:
    Agata Poświata, Kamila Kozik, Marta Miączyńska, Daria Zdżalik-Bielecka
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2021, tom: brak, strony: brak), Wydawca: Springer Science+Business Media
    Status:
    Submitted
    DOI:
    brak - link to the publication

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