Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Examining the phototoxicity of melanin in melanoma pathogenesis

2015/19/D/ST4/01964

Keywords:

Melanin Phototoxicity Melanoma

Descriptors:

  • ST4_13: Solid-state chemistry, surface physicochemistry
  • ST5_21:
  • NZ1_3: Biophysics

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Michał Sarna 

Number of co-investigators in the project: 3

Call: SONATA 10 - announced on 2015-09-15

Amount awarded: 486 000 PLN

Project start date (Y-m-d): 2016-07-08

Project end date (Y-m-d): 2021-07-07

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komora akustyczna (16 420 PLN)
  2. Symulator słoneczny ze światłowodem do naświetlania komórek w komorze inkubacyjnej (120 000 PLN)
  3. Wirówka z chłodzeniem (30 000 PLN)
  4. System do kompresji trójwymiarowych układów komórkowych.

Information in the final report

  • Publication in academic press/journals (10)
  • Articles in post-conference publications (1)
  1. Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion
    Authors:
    Michal Sarna, Martyna Krzykawska-Serda, Monika Jakubowska, Andrzej Zadlo, Krystyna Urbanska
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 9280), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-45643-9 - link to the publication
  2. Triggering NETosis via protease-activated receptor (PAR)-2 signaling as a mechanism of hijacking neutrophils function for pathogen benefits
    Authors:
    Danuta Bryzek, Izabela Ciaston, Ewelina Dobosz, Anna Gasiorek, Anna Makarska, Michal Sarna, Eick Sigrun, Magdalena Puklo, Maciej Lech, Barbara Potempa, Jan Potempa, Joanna Koziel
    Academic press:
    PLoS Pathogens (rok: 2019, tom: 15(5), strony: e1007773), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.ppat.1007773 - link to the publication
  3. Fine particulate matter-induced oxidative stress mediated by UVA-visible light leads to keratinocyte damage
    Authors:
    Krystian Mokrzyński, Olga Krzysztyńska-Kuleta, Marcin Zawrotniak, Michał Sarna, Tadeusz Sarna
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(19), strony: 10645), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms221910645 - link to the publication
  4. Melatonin exerts oncostatic capacity and decreases melanogenesis in human MNT-1 melanoma cells
    Authors:
    Konrad Kleszczyński, Tae‐Kang Kim, Bernadetta Bilska, Michal Sarna, Krystian Mokrzynski, Agatha Stegemann, Elżbieta Pyza, Russel J. Reiter, Kerstin Steinbrink, Markus Böhm, Andrzej T. Slominski
    Academic press:
    Journal of Pineal Research (rok: 2019, tom: 67, strony: e12610), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/jpi.12610 - link to the publication
  5. The role of hydrogen peroxide and singlet oxygen in the photodegradation of melanin
    Authors:
    Andrzej Żądło, Shosuke Ito, Michał Sarna, Kazumasa Wakamatsu, Krystian Mokrzyński, Tadeusz Sarna
    Academic press:
    Photochemical and Photobiological Sciences (rok: 2020, tom: 19(5), strony: 654-667), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c9pp00481e - link to the publication
  6. Photoreactivity of hair melanin from different skin phototypes - contribution of melanin subunits to the pigments photoreactive properties
    Authors:
    Krystian Mokrzynski, Shosuke Ito, Kazumasa Wakamatsu, Theodore Camenish, Tadeusz Sarna, Michal Sarna
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(9), strony: 4465), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094465 - link to the publication
  7. Highly effective protocol for differentiation of induced pluripotent stem cells (iPS) into melanin-producing cells
    Authors:
    Maciej Sułkowski, Marta Kot, Bogna Badyra, Anna Paluszkiewicz, Przemysław M. Płonka, Michał Sarna, Dominika Michalczyk-Wetula, Fabio A. Zucca, Luigi Zecca, Marcin Majka
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(23), strony: 12787), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222312787 - link to the publication
  8. Nanomechanical phenotype of melanoma cells depends solely on the amount of endogenous pigment in the cells
    Authors:
    Michal Sarna, Andrzej Zadlo, Barbara Czuba-Pelech, Krystyna Urbanska
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19, strony: E607), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19020607 - link to the publication
  9. Photobleaching of pheomelanin increases its phototoxic potential: Physicochemical studies of synthetic pheomelanin subjected to aerobic photolysis
    Authors:
    Andrzej Zadlo, Grzegorz Szewczyk, Michal Sarna, Theodore G. Camenisch, Jason W. Sidabras, Shosuke Ito, Kazumasa Wakamatsu, Filip Sagan, Mariusz Mitoraj, Tadeusz Sarna
    Academic press:
    Pigment Cell and Melanoma Research (rok: 2019, tom: 32, strony: 359-372), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/pcmr.12752 - link to the publication
  10. Photoreactivity and phototoxicity of experimentally photodegraded hair melanosomes from individuals of different skin phototypes
    Authors:
    Krystian Mokrzyński, Michał Sarna, Tadeusz Sarna
    Academic press:
    Journal of Photochemistry and Photobiology B: Biology (rok: 2023, tom: 243, strony: 112704), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jphotobiol.2023.112704 - link to the publication
  1. Photoreactivity of natural melanin pigments
    Authors:
    Michal Sarna, Krystian Mokrzynski, Andrzej Zadlo, Grzegorz Szewczyk, Tadeusz Sarna
    Conference:
    2018 Biennial Meeting of the American Society for Photobiology (rok: 2018, ), Wydawca: American Society for Photobiology
    Data:
    konferencja 12-15 Maj
    Status:
    Published

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