Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Physiological significance of decrease in PARP1 expression for the activation of proximal and distal (enhancers) cis-regulatory regions of NF-kB-dependent genes IL1b and TNFa during differentiation of proinflammatory macrophages (phenotype M1) and their activation with bacterial endotoxin

2015/19/N/NZ2/01735

Keywords:

proinflammatory macrophages M1 transcription chromatin ADP-ribosylation proximal and distal (enhancers) cis-regulatory regions

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ3_1: Cell biology
  • NZ2_6: Immunogenetics

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Ewelina Woźniak 

Number of co-investigators in the project: 2

Call: PRELUDIUM 10 - announced on 2015-09-15

Amount awarded: 149 947 PLN

Project start date (Y-m-d): 2016-08-12

Project end date (Y-m-d): 2017-09-25

Project duration:: 13 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (1)
  • Book publications / chapters in book publications (2)
  1. PARP1 facilitates EP300 recruitment to the promoter of the subset of RBL-2 dependent genes
    Authors:
    Robaszkiewicz Agnieszka, Wiśnik Ewelina, Regdon Zsolt, Chmielewska Kinga, Virag Laszlo.
    Academic press:
    BBA Gene Regulatory Mechanisms (rok: 2017, tom: Nie dotyczy, strony: 41-53), Wydawca: Nie dotyczy
    Status:
    Published
    DOI:
    10.1016/j.bbagrm.2017.12.001. - link to the publication
  1. Olaparib – inhibitor PARP1 w terapii raka jajnika.
    Authors:
    Ewelina Wiśnik
    Book:
    Badania i Rozwój Młodych Naukowców w Polsce. Choroby i nowotwory (rok: 2017, tom: Nie dotyczy, strony: 111-116), Wydawca: Młodzi Naukowcy
    Status:
    Published
  2. Proksymalne i dystalne sekwencje cis-regulatorowe i ich rola w ludzkich chorobach
    Authors:
    Ewelina Wiśnik
    Book:
    Badania i Rozwój Młodych Naukowców w Polsce. Choroby i nowotwory (rok: 2017, tom: Nie dotyczy, strony: 117-121), Wydawca: Młodzi Naukowcy
    Status:
    Published

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