Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Diversity of immuno-reactivity of endolysins as the factor determining differences in their antibacterial potential in vivo

2015/18/M/NZ6/00412

Keywords:

endolysin antibioticresistance antibodies cytokines

Descriptors:

  • NZ4_12: Other related subjects
  • NZ7_12: Prevention of human diseases
  • NZ6_8: Other related subjects

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Krystyna Dąbrowska 

Number of co-investigators in the project: 4

Call: HARMONIA 7 - announced on 2015-06-15

Amount awarded: 1 108 800 PLN

Project start date (Y-m-d): 2016-04-12

Project end date (Y-m-d): 2020-03-11

Project duration:: 47 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (5)
  1. ClyJ Is a Novel Pneumococcal Chimeric Lysin with a Cysteine- and Histidine-Dependent Amidohydrolase/Peptidase Catalytic Domain
    Authors:
    Hang Yang, Yujing Gong, Huaidong Zhang, Irina Etobayeva, Paulina Miernikiewicz, Dehua Luo, Xiaohong Li, Xiaoxu Zhang, Krystyna Dąbrowska, Daniel C Nelson, Jin He, Hongping Wei
    Academic press:
    Antimicrobial Agents and Chemotherapy (rok: 2019, tom: 63, strony: e02043-18), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/AAC.02043-18 - link to the publication
  2. DNA dyes in detection of bacteriolytic activity: high speed, precision, and sensitivity demonstrated with endolysins
    Authors:
    Marek A. Harhala, Katarzyna Gembara, Paulina Miernikiewicz, Barbara Owczarek, Zuzanna M. Kazmierczak, Joanna M. Majewska, Krystyna Dąbrowska, Daniel Nelson
    Academic press:
    Frontiers in Microbiology , Wydawca: FRONTIERS MEDIA SA
    Status:
    Submitted
    DOI:
    brak - link to the publication
  3. Two novel lysogenic bacteriophages infecting Streptococcus pyogenes: their genomes, morphology and stability.
    Authors:
    Harhala M, Barylski J, Huminska K, Lecion D, Wojciechowicz J, Lahutta K, Kuś M, Kropinski AM, Nowak S, Nowicki G, Hodyra-Stefaniak K, Dąbrowska K.
    Academic press:
    PLoS ONE (rok: 2018, tom: 13(10), strony: e0205995), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0205995 - link to the publication
  4. Phage therapy: What factors shape phage pharmacokinetics and bioavailability? Systematic and critical review
    Authors:
    Krystyna Dąbrowska
    Academic press:
    Medical Research Reviews (rok: 2019, tom: 39, strony: 2000-2025), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/med.21572 - link to the publication
  5. Safety studies of pneumococcal endolysins Cpl-1 and Pal
    Authors:
    Harhala M, Nelson DC, Miernikiewicz P, Heselpoth RD, Brzezicka B, Majewska J, Linden SB, Shang X, Szymczak A, Lecion D, Marek-Bukowiec K, Kłak M, Wojciechowicz B, Lahutta K, Konieczny A, Dąbrowska K.
    Academic press:
    Viruses (rok: 2018, tom: 10(11), strony: 638), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v10110638 - link to the publication
  6. Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System
    Authors:
    Jonas D. Van Belleghem, Krystyna Dabrowska, Mario Vaneechoutte, Jeremy J. Barr, Paul L. Bollyky
    Academic press:
    Viruses-Basel (rok: 2019, tom: 11, strony: 10), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v11010010 - link to the publication
  7. Escaping antibody responses to bacteriolytic enzymes Pal and Cpl-1 by epitope scanning and engineering
    Authors:
    Marek Harhala, Katarzyna Gembara, Izabela Rybicka, Zuzanna Kaźmierczak, Paulina Miernikiewicz, Joanna Majewska, Wiktoria Budziar , Daniel C. Nelson, Krystyna Dąbrowska
    Academic press:
    Cellular & Molecular Immunology , Wydawca: CHIN SOCIETY IMMUNOLOGY
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Bioinformatic protocol for epitope prediction and its application in analysis of laboratory data for exemplary bacteriophage proteins
    Authors:
    Harhala M, Hodyra-Stefaniak K, Dąbrowska K
    Conference:
    2nd Congress of Polish Biochemistry, Cell biology, Biotechnology and Bioinformatics Bio2016 – Expanding beyond the limits" (rok: 2016, ), Wydawca: Uniwersytet Wrocławski
    Data:
    konferencja 13-16 wrzesnia 2016
    Status:
    Published
  2. Kinetic characteristics of endolysins in human serum
    Authors:
    Katarzyna Gembara, Marek Harhala, Wojciech Witkiewicz, Krystyna Dąbrowska
    Conference:
    9th Annual Conference Phages 2019 Bacteriophage in Medicine, Food and Biotechnology, St Hilda's College, Oxford, Wlk. Brytania, (rok: 2019, ), Wydawca: St Hilda's College
    Data:
    konferencja 11 – 12.09.2019
    Status:
    Published
  3. Safety Studies of Pneumococcal Endolysins Cpl-1 and Pal
    Authors:
    Marek Harhala, Daniel C. Nelson, Paulina Miernikiewicz, Ryan D. Heselpoth, Beata Brzezicka, Joanna Majewska, Sara B. Linden, Xiaoran Shang, Aleksander Szymczak, Dorota Lecion, Karolina Marek-Bukowiec, Marlena Kłak, Bartosz Wojciechowicz, Karolina Lahutta, Andrzej Konieczny, and Krystyna Dąbrowska
    Conference:
    23th Biennial Evergreen International Phage Meeting, Olympia, Washington, U.S.A. (rok: 2019, ), Wydawca: Evergreen State College, US
    Data:
    konferencja 04-09.08.2019
    Status:
    Published
  4. Bioinformatic protocol for epitope prediction and its application in analysis of laboratory data for exemplary endolysins
    Authors:
    Harhala M, Kłopot A, Dąbrowska K
    Conference:
    The 1st International Symposium on Antimicrobial Hydrolytic Enzymes: The Lysin Meeting (rok: 2016, ), Wydawca: Rockefeler University
    Data:
    konferencja 17-19.11.2016
    Status:
    Published
  5. More accurate and medically relevant evaluation of anti-Streptococcus pneumoniae endolysins Cpl-1 and Pal by using fluorescent assay
    Authors:
    Marek Harhala, Katarzyna Gembara, Beata Brzezicka, Daniel C. Nelson, Krystyna Dąbrowska
    Conference:
    9th Annual Conference Phages 2019 Bacteriophage in Medicine, Food and Biotechnology, St Hilda's College, Oxford, Wlk. Brytania, (rok: 2019, ), Wydawca: St Hilda's College
    Data:
    konferencja 11-12.09.2019
    Status:
    Published

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