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Role of synaptic plasticity impairments in the development of asocial phenotype in mouse models of autism

2015/18/E/NZ4/00600

Keywords

Descriptors

  • NZ4_7: Neurofizjologia
  • NZ4_9: Neurobiologia systemowa
  • NZ3_6: Neurobiologia komórkowa

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Ksenia Zuzanna Meyza

Number of co-investigators in the project: 3

Call

SONATA BIS 5 – announced on 2015-06-15

Amount awarded
1 050 000 PLN
Project start date
2016-09-01
Project end date
2022-08-31
Project duration
72 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Aparat stereotaktyczny z wyświetlaczem cyfrowym. Cost: 50 000 PLN
  2. CED Power1401-3 do rejestracji sygnałów elektrofizjologicznych. Cost: 31 000 PLN
  3. Cieplarka - komora do inkubacji skrawków. Cost: 7 500 PLN
  4. Obiektyw fluorescencyjny oraz źródło światła do aparatury elektrofizjologicznej. Cost: 9 000 PLN
  5. Oprogramowanie CED Signal6.
  6. Oprogramowanie CED Spike2. Cost: 9 000 PLN
  7. Wibratom. Cost: 40 000 PLN
  8. Wirówka. Cost: 10 000 PLN
  9. Wytrząsarka kołowa. Cost: 4 500 PLN
  10. Zestaw komputerowy. Cost: 7 000 PLN

Information in the final report

Publication in academic press/journals (5)

  1. The roots of empathy: Through the lens of rodent models.

    Authors:
    Meyza KZ, Bartal IB, Monfils MH, Panksepp JB, Knapska E
    Academic press:
    Neuroscience & Biobehavioral Reviews (year: 2017, volume: 76(Pt B), pages: 216-234), Publisher: Elsevier
    Status:
    Published

  2. The BTBR mouse model of idiopathic autism - Current view on mechanisms.

    Authors:
    Meyza KZ, Blanchard DC
    Academic press:
    Neuroscience &Biobehavioral Reviews (year: 2017, volume: 76(Pt A), pages: 99-110), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neubiorev.2016.12.037 – link to the publication

  3. What can rodents teach us about empathy?

    Authors:
    Meyza K., Knapska E.
    Academic press:
    Current Opinion in Psychology (year: 2018, volume: Volume 24, pages: 15-20), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.copsyc.2018.03.002 – link to the publication

  4. Social deficits in BTBR T+ Itpr3tf/J mice vary with ecological validity of the test.

    Authors:
    Winiarski, M., Kondrakiewicz, L., Kondrakiewicz, K., Jędrzejewska-Szmek, J., Turzyński, K., Knapska, E., Meyza, K.
    Academic press:
    Genes, brain, and behavior (year: 2022, volume: 21(5), pages: e12814), Publisher: Wiley Online Library
    Status:
    Published
    DOI:
    10.1111/gbb.12814 – link to the publication

  5. Targeted therapy of cognitive deficits in fragile X syndrome.

    Authors:
    Puścian, A., Winiarski, M., Borowska, J., Łęski, S., Górkiewicz, T., Chaturvedi, M., Nowicka, K., Wołyniak, M., Chmielewska, J. J., Nikolaev, T., Meyza, K., Dziembowska, M., Kaczmarek, L., & Knapska, E.
    Academic press:
    Molecular psychiatry (year: 2022, volume: 27(6), pages: 2766–2776), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41380-022-01527-5 – link to the publication

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Graphic design and implementation: Jakub Piotrowski