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DNA repair in hematopoietic stem cells: what is a role of nuclear heme oxygenase-1?

2015/18/M/NZ3/00387

Keywords

Descriptors

  • NZ3_8: Komórki macierzyste
  • NZ3_1: Biologia komórki
  • NZ3_4: Starzenie

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Alicja Józkowicz

Number of co-investigators in the project: 8

Call

HARMONIA 7 – announced on 2015-06-15

Amount awarded
1 334 400 PLN
Project start date
2016-05-13
Project end date
2020-05-12
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (8)

  1. Role of HMOX1 promoter genetic variants in chemoresistance and chemotherapy-induced neutropenia in children with acute lymphoblastic leukemia.

    Authors:
    3.Bukowska-Strakova K., Włodek J., Pitera E., Konturek-Cieśla A., Cieśla M., Kozakowska M., Gońka M., Nowak W., Wieczorek A., Pawinska-Wasikowska K., Józkowicz A., Siedlar M.
    Academic press:
    Int J Mol Sci (year: 2021, volume: 22, pages: 46044), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22030988 – link to the publication

  2. Murine bone marrow mesenchymal stromal cells respond efficiently to oxidative stress despite the low level of heme oxygenases 1 and 2.

    Authors:
    Nowak WN, Taha H, Kachamakova-Trojanowska N, Stepniewski J, Markiewicz J, Kusienicka A, Szade K, Szade A, Bukowska-Strakova K, Hajduk K, Kloska D, Kopacz A, Grochot-Przeczek A, Barthenheier K, Cauvin C, Dulak J, Jozkowicz A.
    Academic press:
    Antioxid Redox Signal (year: 2018, volume: 29, pages: 111-127), Publisher: Mary Ann Liebert Inc Publishers
    Status:
    Published
    DOI:
    10.1089/ars.2017.7097 – link to the publication

  3. Analysis of cell cycle status of murine hematopoietic stem cells.

    Authors:
    Szade K, Bukowska-Strakova K, Zukowska M, Jozkowicz A, Dulak J.
    Academic press:
    Methods Mol Biol (year: 2016, volume: 1516, pages: 91-99), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/7651.2016.361 – link to the publication

  4. Neogenin-1 distinguishes between myeloid-biased and balanced Hoxb5 + mouse long-term hematopoietic stem cells

    Authors:
    Gulati GS, Zukowska M, Noh JJ, Zhang A, Wesche DJ, Sinha R, George BM, Weissman IL, Szade K.
    Academic press:
    Proc Natl Acad Sci USA (year: 2019, volume: 116, pages: 46033), Publisher: National Academy of Sciences (United States)
    Status:
    Published

  5. Heme oxygenase-1 protects cells from replication stress

    Authors:
    Patryk Chudy, Jakub Kochan, Mateusz Wawro, Phu Nguyen, Monika Gorczyca, Aliaksandra Varanko, Aleksandra Retka, Swati Sweta Ghadei, Emilija Napieralska, Anna Grochot-Przęczek, Krzysztof Szade, Lea-Sophie Berendes, Julien Park, Grzegorz Sokołowski, Qiuliyang Yu, Alicja Jozkowicz, Witold N. Nowak, Wojciech Krzeptowski
    Academic press:
    Redox Biology (year: 2024, volume: 75, pages: 46039), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2024.103247 – link to the publication

  6. Cobalt protoporphyrin IX increases endogenous G-CSF and mobilizes hematopoietic stem cells and granulocytes to the blood

    Authors:
    Szade A, Szade K, Nowak WN, Bukowska-Strakova K, Muchova L, Cieśla M, Kachamakova-Trojanowska N, Rams-Baron M, Ratuszna A, Dulak J, Józkowicz A
    Academic press:
    EMBO Mol Med (year: 2019, volume: 11, pages: 46039), Publisher: EMBO Press
    Status:
    Published
    DOI:
    10.15252/emmm.201809571 – link to the publication

  7. Atorvastatin and conditioned media from atorvastatin-treated human hematopoietic stem/progenitor-derived cells show proangiogenic activity in vitro but not in vivo

    Authors:
    Nowak WN1, Taha H, Markiewicz J, Kachamakova-Trojanowska N, Stępniewski J, Klóska D, Florczyk-Soluch U, Niżankowski R, Frołow M, Walter Z, Dulak J, Józkowicz A
    Academic press:
    Mediators of Inflammation (year: 2019, volume: 2019, pages: 46037), Publisher: Hindawi
    Status:
    Published
    DOI:
    10.1155/2019/1868170 – link to the publication

  8. Heme oxygenase-1 deficiency affects bone marrow niche and triggers premature exhaustion of hematopoietic stem cells

    Authors:
    Szade K, Zukowska M, Szade A, Nowak W, Ciesla M, Bukowska-Strakova K, Gulati GS, Kachamakova-Trojanowska N, Kusienicka A, Einwallner E, Kijowski J, Czauderna S, Esterbauer H, Weissman I, Dulak J, Jozkowicz A
    Academic press:
    EMBO Rep (year: 2020, volume: 21, pages: 46043), Publisher: EMBO Press
    Status:
    Published
    DOI:
    10.15252/embr.201947895 – link to the publication

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